{"id":19418,"date":"2019-07-18T09:00:53","date_gmt":"2019-07-18T01:00:53","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=19418"},"modified":"2021-08-04T11:18:28","modified_gmt":"2021-08-04T03:18:28","slug":"%e7%94%a2%e5%ad%b8%e5%90%88%e4%bd%9c%e6%96%b0%e7%aa%81%e7%a0%b4%ef%bc%81-%e8%87%ba%e7%81%a3%e8%9b%8b%e7%99%bd%e8%b3%aa%e8%a8%88%e7%95%ab%e8%88%87%e7%94%9f%e6%8a%80%e5%85%ac%e5%8f%b8%e5%85%b1%e5%89%b5d","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/19418\/","title":{"rendered":"\u7522\u5b78\u5408\u4f5c\u65b0\u7a81\u7834\uff01 \u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u8207\u751f\u6280\u516c\u53f8\u5171\u5275DNA\u5b9a\u5e8f\u65b0\u65b9\u6cd5"},"content":{"rendered":"

\u7522\u5b78\u5408\u4f5c\u65b0\u7a81\u7834\uff01\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\uff08Taiwan Protein Project, TPP\uff09\u7531\u672c\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u7279\u8058\u7814\u7a76\u54e1\u8521\u660e\u9053\u9662\u58eb\u4e3b\u6301\uff0c\u8a72\u8a08\u756b\u8fd1\u671f\u8207\u9ad4\u5b78\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\u5408\u4f5c\uff0c\u63d0\u51fa\u7528DNA\u805a\u5408\u9176\u555f\u52d5\u300c\u4e0b\u4e00\u4ee3DNA\u5b9a\u5e8f\u65b0\u65b9\u6cd5\u300d\u3002\u7814\u7a76\u8ad6\u6587\u65bc108\u5e746\u670820\u65e5\u520a\u8f09\u65bc\u300a\u81ea\u7136\u79d1\u7814\u901a\u8a0a-\u751f\u7269\u5b78\u671f\u520a\u300b\uff08Nature Research-Communications Biology<\/em>\uff09\u3002\u8521\u660e\u9053\u8868\u793a\uff0c\u672c\u7814\u7a76\u662f\u9ad8\u968e\u7522\u5b78\u5408\u4f5c\u7684\u6210\u529f\u6848\u4f8b\uff0c\u5229\u7528\u7814\u7a76\u5718\u968a\u7684\u751f\u5316\u77e5\u8b58\uff0c\u4e0d\u4f46\u89e3\u6c7a\u696d\u754c\u7684\u5be6\u52d9\u554f\u984c\uff0c\u5176\u7a81\u7834\u6027\u6210\u679c\u4e5f\u5c0d\u7814\u7a76\u9818\u57df\u6709\u91cd\u8981\u8ca2\u737b\u3002<\/p>\n

\u7531A\u3001T\u3001C\u3001G\u56db\u7a2e\u9e7c\u57fa\u5c0d\u6392\u5217\u7d44\u5408\u7684DNA\u662f\u751f\u547d\u7684\u907a\u50b3\u5bc6\u78bc\u3002\u70baDNA\u5b9a\u5e8f\uff0c\u5df2\u662f\u7576\u4eca\u79d1\u5b78\u7814\u7a76\u3001\u81e8\u5e8a\u91ab\u5b78\u3001\u85e5\u7269\u958b\u767c\u7684\u95dc\u9375\u6280\u8853[1]<\/a>\u3002\u7136\u800c\uff0c\u76ee\u524d\u5e02\u9762\u4e0a\u6700\u5e38\u7528\u7684DNA\u5b9a\u5e8f\u6cd5[2]<\/a>\u537b\u6709\u5169\u500b\u4e3b\u8981\u5c40\u9650\uff1a\u9808\u5206\u4e8c\u968e\u6bb5\u9032\u884c\uff0c\u4e14\u9808\u4f7f\u7528\u5316\u5b78\u85e5\u5291\u3002\u4e0d\u4f46\u7121\u5f62\u4e2d\u4f7f\u5b9a\u5e8f\u7684\u6210\u672c\u589e\u52a0\u3001\u901f\u5ea6\u8b8a\u6162\uff0c\u5176\u8b80\u53d6DNA\u9e7c\u57fa\u5c0d\u7684\u6578\u91cf\u4e5f\u8f03\u5c11\u3002\u5c0d\u6b64\uff0c\u9ad4\u5b78\u516c\u53f8\u65bc2016\u5e74\u63d0\u51fa\u4e00\u5957\u6539\u826f\u69cb\u60f3\uff0c\u5229\u75283\u2019\u916f\u5316\u7684\u8131\u6c27\u6838\u7cd6\u6838\u82f7\u4e09\u78f7\u9178[3]<\/a>\uff08dNTP\uff09\u4ee5\u53ca\u4e00\u7a2e\u4f86\u81ea\u6d77\u5e95\u55dc\u71b1\u53e4\u83cc\u3001\u540d\u70ba\u300cThermococcus sp. 9\u00b0N DNA\u805a\u5408\u9176\u300d\u7684\u9175\u7d20\uff0c\u5373\u53ef\u4e00\u6b21\u6027\u5b8c\u6210\u5b9a\u5e8f\u53cd\u61c9\u3002\u6b64\u69cb\u60f3\u7d42\u65bc\u5728\u8207\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u5408\u4f5c\u5f8c\uff0c\u5176\u53ef\u884c\u6027\u65bc\u8fd1\u671f\u5f97\u5230\u8b49\u5be6\u3002<\/p>\n

DNA\u805a\u5408\u9176\u662f\u751f\u7269\u9032\u884c\u8907\u88fdDNA\u6642\u6240\u4f7f\u7528\u7684\u9175\u7d20\uff0c\u8eab\u70ba\u570b\u969b\u9175\u7d20\u5c08\u5bb6\u7684\u8521\u660e\u9053\u9662\u58eb\u8868\u793a\uff0c\u672c\u7814\u7a76\u9996\u5148\u8b49\u660e\u4e86Thermococcus sp. 9\u00b0N DNA\u805a\u5408\u9176\u53ef\u50ac\u5316\u4f7f\u75283\u2019\u916f\u5316\u7684dNTP\u7684DNA\u5b9a\u5e8f\u53cd\u61c9[4]<\/a>\uff0c\u518d\u4ee5\u8cea\u8b5c\u6280\u8853\uff0c\u8b49\u5be6\u8a72\u53cd\u61c9\u53ef\u9023\u7e8c\u767c\u751f\u4e0d\u4e2d\u65b7\u3002\u6700\u5f8c\uff0c\u900f\u904e\u4e0d\u540c\u984f\u8272\u7684\u87a2\u5149\u6a19\u8a18\u5f8c\u767c\u73fe\uff0c\u6b64\u53cd\u61c9\u4e00\u6b21\u5373\u53ef\u9032\u884c\u5230\u7d04450\u500b\u9e7c\u57fa\u5c0d\u3002\u672a\u4f86\u9032\u4e00\u6b65\u512a\u5316\u4e4b\u5f8c\uff0c\u5728\u901f\u5ea6\u3001\u6210\u672c\u53ca\u7522\u91cf\uff0c\u7686\u6709\u6a5f\u6703\u8d85\u8d8a\u65e2\u6709\u7684\u65b9\u6cd5\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u4e5f\u5f37\u8abf\uff0c\u9019\u9805\u6280\u8853\u7684\u95dc\u9375\u6b65\u9a5f\u5728\u65bc\u53cd\u61c9\u904e\u7a0b\u4e2d\u7684\u4e2d\u9593\u7522\u7269\u4e5f\u53ef\u88ab\u76f4\u63a5\u5075\u6e2c\uff0c\u56e0\u800c\u514d\u6389\u4e86\u5206\u4e8c\u968e\u6bb5\u9032\u884c\u3002\u7814\u7a76\u5718\u968a\u4e5f\u89e3\u6790\u51fa\u591a\u500b\u4e2d\u9593\u7522\u7269\u7684\u6676\u9ad43D\u7d50\u69cb\uff0c\u5c07\u6709\u52a9\u77ad\u89e3\u6b64\u805a\u5408\u9176\u65b9\u6cd5\u7684\u904b\u4f5c\u6a5f\u5236\u3002\u9664\u4e86DNA\u5b9a\u5e8f\uff0c \u6b64\u7814\u7a76\u5c0d\u751f\u7269\u6aa2\u6e2c\u53ca\u85e5\u7269\u958b\u767c\u7b49\u7686\u5177\u61c9\u7528\u6f5b\u529b\u3002<\/p>\n

\u904e\u53bb\u5c07\u7814\u7a76\u6210\u679c\u6280\u8f49\u7d66\u7522\u696d\u767c\u5c55\u7684\u5408\u4f5c\u6a21\u5f0f\uff0c\u5e38\u6709\u7814\u7a76\u767c\u73fe\u7121\u6cd5\u89e3\u6c7a\u5be6\u969b\u554f\u984c\u7684\u5c37\u5c2c\u60c5\u5f62\u3002\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u70ba\u884c\u653f\u9662\u653f\u7b56\u984d\u5ea6\u652f\u6301\u7684\u8a08\u756b\uff0c\u5176\u4f7f\u547d\u4e4b\u4e00\uff0c\u4fbf\u662f\u5354\u52a9\u6211\u570b\u751f\u6280\u7522\u3001\u5b78\u3001\u7814\u754c\uff0c\u91dd\u5c0d\u5be6\u969b\u554f\u984c\uff0c\u63d0\u51fa\u57fa\u790e\u7814\u7a76\u7684\u7a81\u7834\u6027\u89e3\u6c7a\u4e4b\u9053\u3002\u4ea6\u5373\uff0c\u5728\u696d\u754c\u5c1a\u8655\u65bc\u69cb\u60f3\u968e\u6bb5\u6642\uff0c\u5373\u900f\u904e\u7814\u7a76\u4eba\u54e1\u53c3\u8207\uff0c\u5f15\u5165\u5148\u9032\u7684\u86cb\u767d\u8cea\u77e5\u8b58\u8207\u5be6\u9a57\u6280\u8853\uff0c\u63d0\u51fa\u5177\u9ad4\u5c0d\u7b56\u3002\u8521\u660e\u9053\u4e5f\u8aaa\uff0c\u672c\u6b21\u5408\u4f5c\u6210\u679c\u4e5f\u986f\u793a\u81fa\u7063\u696d\u8005\u7684\u63d0\u5347\uff0c\u4e0d\u518d\u53ea\u662f\u4ee3\u5de5\uff0c\u800c\u662f\u5f9e\u7814\u767c\u4e2d\u7368\u5275\u3002<\/p>\n

\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u7684\u526f\u7e3d\u7d93\u7406\u3001\u751f\u5316\u6240\u5433\u6587\u6649\u7814\u7a76\u526f\u6280\u5e2b\u8868\u793a\uff0c\u76ee\u524d\u672c\u8a08\u756b\u5df2\u8207\u570b\u5167\u7522\u3001\u5b78\u3001\u7814\u7b49\u55ae\u4f4d\u53d6\u5f97\u5171370\u4ef6\u8a08\u756b\u6210\u679c\uff0c\u5176\u4e2d\u5305\u542b20\u591a\u5bb6\u751f\u6280\u696d\u8005\u5be6\u969b\u9762\u81e8\u7684\u554f\u984c\u3002\u6b64\u8a08\u756b\u63d0\u4f9b\u5c08\u696d\u7684\u86cb\u767d\u8cea\u7814\u7a76\u5718\u968a\uff0c\u4e5f\u5229\u7528\u570b\u5167\u86cb\u767d\u8cea\u7814\u7a76\u6240\u9700\u7684\u7cbe\u5bc6\u5100\u5668\u8a2d\u65bd\uff0c\u5305\u542b\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\uff08Cryo-EM\uff09\u3001\u570b\u5bb6\u540c\u6b65\u8f3b\u5c04\u4e2d\u5fc3\u3001\u6838\u78c1\u5171\u632f\u5149\u8b5c\u53ca\u8cea\u8b5c\u5100\u7b49\u3002<\/p>\n

\u672c\u8ad6\u6587\u7531\u8521\u660e\u9053\u9662\u58eb\u3001\u5433\u6587\u6649\u7814\u7a76\u526f\u6280\u5e2b\u3001\u751f\u5316\u6240\u99ac\u5de6\u4ef2\u5ba2\u5ea7\u52a9\u7406\u6559\u6388\u53ca\u9ad4\u5b78\u751f\u7269\u79d1\u6280\u516c\u53f8\u6797\u5433\u5ba3\u7152\u535a\u58eb\u3001\u8521\u5ef7\u5cb3\u535a\u58eb\u3001\u7d00\u5b8f\u6587\u535a\u58eb\u3001\u90b1\u5275\u6c4e\u6280\u8853\u9577\u3001\u674e\u937e\u7199\u8463\u4e8b\u9577\u7b49\u4eba\u5171\u540c\u63d0\u51fa\u3002\u8ad6\u6587\u6a19\u984c\u70ba \u201cThermococcus sp. 9\u00b0N DNA polymerase exhibits 3\u2032-esterase activity that can be harnessed for DNA sequencing\u201d<\/em>\uff0c<\/p>\n

\u8ad6\u6587\u5168\u6587\u8acb\u898b\uff1ahttps:\/www.nature.com\/articles\/s42003-019-0458-7<\/a><\/p>\n

 <\/p>\n

\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\uff08TPP\uff09\u7db2\u7ad9\uff1ahttp:\/tpp.sinica.edu.tw<\/a><\/p>\n

\uff08\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\uff09<\/p>\n

——————————————————————<\/p>\n

[1]<\/a> DNA\u5b9a\u5e8f\u672a\u4f86\u5c07\u6709\u66f4\u591a\u61c9\u7528\uff0c\u5305\u542b\u5065\u5eb7\u7ba1\u7406\u3001\u764c\u75c7\u6a19\u9776\u7528\u85e5\u53c3\u8003\u3001\u500b\u4eba\u5316\u91ab\u7642\u7b49\uff0c\u751a\u81f3\u53ef\u7528\u5728\u74b0\u5883\u6aa2\u6e2c\u3001\u6253\u64ca\u72af\u7f6a\u9762\u5411\uff0c\u96a8\u8457\u79d1\u6280\u9032\u6b65\u8207\u666e\u53ca\uff0c\u66f4\u5c07\u64f4\u5927\u5176\u5e02\u5834\u898f\u6a21\u3002<\/p>\n

[2]<\/a> \u7f8e\u570b\u751f\u6280\u516c\u53f8Illumina\u4f7f\u7528\u7684\u300c\u5faa\u74b0\u53ef\u9006\u7d42\u6b62\u6cd5\u300d\uff0c\u5148\u4ee5\u5316\u5b78\u8a66\u5291\u4fee\u98fedNTP\uff0c\u5728\u6bcf\u500b\u5faa\u74b0\u4e2d\uff0c\u7686\u9808\u66ab\u505c\u5207\u5272\u3001\u56e0\u6b64\u6709\u901f\u5ea6\u6162\u3001\u8b80\u53d6\u9577\u5ea6\u8f03\u77ed\u7b49\u4fb7\u9650\u3002<\/p>\n

[3]<\/a> DNA\u7684\u57fa\u672c\u55ae\u4f4d\u662f\u6838\u7518\u9178\uff0c\u6bcf\u500b\u6838\u7518\u9178\u7684\u5316\u5b78\u5f0f\u4e2d\uff0c\u90fd\u6709\u4e00\u4e94\u78b3\u7cd6\uff0c\u4e94\u78b3\u7cd6\u67095\u500b\u7aef\u9ede\uff0c\u7b2c\u4e09\u500b\u7aef\u9ede\u5373\u70ba3\u2019\u7aef\u30023\u2019\u7aef\u5728DNA\u8907\u88fd\u3001\u8f49\u8b6f\u53ca\u5b9a\u5e8f\u7684\u53cd\u61c9\u90fd\u6709\u91cd\u8981\u89d2\u8272\u3002\u672c\u6b21\u7814\u7a76\u4f7f\u7528\u5c073\u2019\u7aef\u916f\u5316\u5f8c\u5f62\u6210\u7684\u7279\u6b8a\u6838\u7518\u9178\u9032\u884c\u5b9a\u5e8f\u53cd\u61c9\u3002<\/p>\n

[4]<\/a> Thermococcus sp. 9\u00b0N DNA\u805a\u5408\u9176\u53ef\u50ac\u53163\u2019\u916f\u5316\u7684\u6838\u82f7\u4e09\u78f7\u9178\u5f15\u5165DNA\u9032\u884c\u8b80\u53d6\u3001\u8907\u88fd\u7b49\u53cd\u61c9\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7522\u5b78\u5408\u4f5c\u65b0\u7a81\u7834\uff01\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\uff08Taiwan Protein Project, TPP\uff09\u7531\u672c\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u7279 […]<\/p>\n","protected":false},"author":1,"featured_media":19419,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19418"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=19418"}],"version-history":[{"count":0,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19418\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/19419"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=19418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=19418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=19418"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}