\u672c\u6240\u81ea\u6210\u7acb46\u5e74\u4ee5\u4f86\uff0c\u5728\u904e\u53bb\u6b77\u4efb\u6240\u9577\u7684\u52aa\u529b\u8207\u63a8\u52d5\u4e0b\uff0c\u7279\u5225\u8457\u529b\u65bc\u500b\u9ad4\u5c64\u6b21\u7684\u751f\u547d\u73fe\u8c61\u4e4b\u7814\u7a76\uff0c\u76ee\u524d\u5df2\u9817\u5177\u6210\u679c\u3002\u5728\u524d\u5169\u4efb\u6240\u9577\u5433\u91d1\u6d0c\u7814\u7a76\u54e1\u53ca\u90b5\u5ee3\u662d\u7814\u7a76\u54e1\u7684\u63a8\u52d5\u4e0b\uff0c\u5feb\u901f\u5730\u6210\u9577\u8207\u86fb\u8b8a\uff0c\u9664\u4e86\u65cf\u7fa4\u751f\u614b\u7684\u7814\u7a76\u4ee5\u5916\uff0c\u672c\u6240\u91cd\u9ede\u70ba\u7d30\u80de\u8207\u500b\u9ad4\u7684\u7814\u7a76\u3002\u4eca\u5e74\u521d\u672c\u624011\u4f4d\u540c\u4ec1\u5305\u62ec\u672c\u6240\u4ee5\u524d\u7814\u7a76\u7cfb\u7d71\u5206\u985e\u3001\u5206\u5b50\u6f14\u5316\u3001\u8edf\u9ad4\u8207\u7121\u810a\u690e\u52d5\u7269\u3001\u6d77\u6d0b\u751f\u614b\u3001\u6606\u87f2\u751f\u614b\u3001\u9ce5\u985e\u884c\u70ba\u8207\u65cf\u7fa4\u7b49\u65b9\u9762\u4eba\u624d\uff0c\u6b63\u5f0f\u8f49\u81f3\u751f\u7269\u591a\u6a23\u6027\u4e2d\u5fc3\u3002\u76ee\u524d\u672c\u6240\u6709\u95dc\u7d30\u80de\u8207\u500b\u9ad4\u7814\u7a76\u65b9\u9762\u7684\u540c\u4ec1\uff0c\u5728\u65b0\u4efb\u6240\u9577\u6e38\u6b63\u535a\u7279\u8058\u7814\u7a76\u54e1\u9818\u5c0e\u4e0b\uff0c\u64f4\u5145\u7814\u7a76\u8a2d\u65bd\u53ca\u6838\u5fc3\u5171\u7528\u5100\u5668\u5ba4\uff0c\u7a4d\u6975\u7db2\u7f85\u4eba\u624d\u3002\u66f4\u65b0\u4e26\u6574\u5408\u672c\u6240\u7d30\u80de\u8207\u500b\u9ad4\u7684\u7814\u7a76\u91cd\u9ede\u53ca\u65b9\u5411\u3002\u7d93\u4eca\u5e744\u67089\u65e5\u8a55\u8b70\u6703\u6703\u8b70\u901a\u904e\uff0c\u672c\u6240\u5373\u5c07\u6539\u540d\u70ba\u300c\u7d30\u80de\u8207\u500b\u9ad4\u751f\u7269\u5b78\u7814\u7a76\u6240\u300d\uff08Institute of Cellular and Organismic Biology\uff1b\u7c21\u7a31\uff1a\u7d30\u751f\u6240\uff09\u3002\u5c07\u7e7c\u7e8c\u4ee5\u7d30\u80de\u53ca\u500b\u9ad4\u5c64\u6b21\u7814\u7a76\u4ea4\u4e92\u61c9\u7528\u63a2\u8a0e\u751f\u547d\u73fe\u8c61\u3002\u6211\u5011\u601d\u8003\u5728\u672c\u9662\u751f\u547d\u79d1\u5b78\u7d44\u6240\u626e\u6f14\u7684\u89d2\u8272\uff0c\u672c\u6240\u5c07\u4ee5\u7d30\u80de\u70ba\u57fa\u790e\u63a2\u8a0e\u52d5\u7269\u500b\u9ad4\u4e4b\u751f\u7269\u79d1\u5b78\uff0c\u505a\u70ba\u672c\u6240\u7684\u7814\u7a76\u91cd\u9ede\u3002<\/p>\n
\u7e3d\u4e4b\uff0c\u672c\u6240\u70ba\u7dad\u6301\u7814\u7a76\u4e0a\u7684\u524d\u77bb\u5730\u4f4d\uff0c\u6211\u5011\u7684\u76ee\u6a19\u5c07\u662f\u900f\u904e\u9662\u5167\u3001\u5916\u5404\u5b78\u79d1\u9593\u7684\u5408\u4f5c\uff0c\u4fc3\u9032\u7814\u7a76\u6d3b\u52d5\u4e4b\u84ec\u52c3\u767c\u5c55\u3002\u76ee\u524d\uff0c\u9664\u4e86\u81e8\u6d77\u7814\u7a76\u7ad9\u53ca\u5e79\u7d30\u80de\u7814\u7a76\u5c07\u96c6\u4e2d\u65bc\u4e0b\u52173\u500b\u65b9\u5411\uff08\u4e00\uff09\u52d5\u7269\u74b0\u5883\u9069\u61c9\u6a5f\u5236\u7684\u6574\u5408\u6027\u7814\u7a76\uff08\u4e8c\uff09\u52d5\u7269\u6a21\u5f0f\u8207\u85e5\u7269\u7be9\u9078\u3001\u4ee5\u53ca\uff08\u4e09\uff09\u52d5\u7269\u75c5\u6bd2\u8207\u6d77\u6d0b\u5929\u7136\u7269\/\u5fae\u751f\u7269\u7814\u7a76\u70ba\u91cd\u9ede\u7684\u63a2\u8a0e\uff08\u8a73\u898b\u9644\u5716\uff09\uff0c\u90fd\u662f\u672c\u6240\u672a\u4f86\u767c\u5c55\u4e4b\u7814\u7a76\u7279\u8272\u3002<\/p>\n
\u91cd\u8981\u7814\u7a76\u6210\u679c\u7c21\u8ff0\u5982\u4e0b\uff1a<\/p>\n
\uff08\u4e00\uff09\u5be6\u9a57\u52d5\u7269\u6a21\u5f0f\u8207\u6d3b\u9ad4\u5feb\u901f\u85e5\u7269\u7be9\u9078<\/p>\n
\u672c\u6240\u5168\u529b\u767c\u5c55\u8f49\u57fa\u56e0\u6591\u99ac\u9b5a\u7814\u7a76\u7cfb\u7d71\uff0c\u4e86\u89e3\u7279\u7570\u5316\u57fa\u56e0\u500b\u5225\u7684\u529f\u80fd\u8207\u8abf\u7bc0\uff0c\u4ee5\u7814\u7a76\u4e0d\u540c\u5668\u5b98\u7684\u767c\u751f\u8207\u76f8\u95dc\u4eba\u985e\u75be\u75c5\u3002\u6211\u5011\u9078\u6b96\u5177\u809d\u8207\u8178\u7279\u7570\u57fa\u56e0\u7684\u555f\u52d5\u5b50\uff0c\u5229\u7528\u7da0\u87a2\u5149\u86cb\u767d(GFP) \u8207\u7d05\u87a2\u5149\u86cb\u767d(RFP) \u4e4b\u8868\u73fe\uff0c\u4f86\u7522\u751f\u57fa\u56e0\u8f49\u6b96\u6591\u99ac\u9b5a\uff0c\u4e26\u5229\u7528\u6b64\u8f49\u57fa\u56e0\u6591\u99ac\u9b5a\u5f9e\u4e8b\u5373\u6642\u76f4\u63a5\u89c0\u5bdf\u5176\u751f\u7269\u500b\u9ad4\u5728\u80da\u80ce\u767c\u80b2\u904e\u7a0b\u4e2d\u809d\u81df\u8207\u6d88\u5316\u9053\u7684\u5f62\u6210\uff0c\u9032\u4e00\u6b65\u767c\u5c55\u6210\u70ba\u75be\u75c5\u52d5\u7269\u6a21\u5f0f\u7684\u7814\u7a76\u3002\u53e6\u5916\uff0c\u4e5f\u5229\u7528BMP4\u5fc3\u81df\u5c08\u4e00\u6027\u555f\u52d5\u5b50\u5efa\u7acb\u5fc3\u81df\u7da0\u87a2\u5149\u7684\u57fa\u56e0\u8f49\u6b96\u9b5a\uff0c\u672a\u4f86\u5c07\u9032\u4e00\u6b65\u63a2\u8a0e\u5728\u5fc3\u81df\u6240\u7522\u751f\u7d30\u80de\u51cb\u4ea1\u4e4b\u6a5f\u5236\u3002\u53e6\u5916\uff0c\u5229\u7528\u9019\u4e9b\u57fa\u56e0\u8f49\u6b96\u9b5a\u9032\u884cENU\u4f86\u7522\u751f\u5316\u5b78\u7a81\u8b8a\u7a2e\uff0c\u672a\u4f86\u5c07\u53ef\u505a\u70ba\u809d\u81df\u3001\u6d88\u5316\u9053\u6216\u5fc3\u81df\u85e5\u7269\u7be9\u9078\u7684\u6750\u6599\u3002
\n \u6591\u99ac\u9b5a\u662f\u4e00\u7a2e\u975e\u5e38\u9069\u5408\u7528\u4f86\u4f5c\u907a\u50b3\u7814\u7a76\u53ca\u85e5\u7269\u7be9\u9078\u7684\u810a\u690e\u52d5\u7269\u6a21\u5f0f\u3002\u6211\u5011\u5c07\u5229\u7528\u6709\u8840\u7ba1\u589e\u751f\u7a81\u8b8a\u7684\u6591\u99ac\u9b5a\uff0c\u4f86\u4f5c\u85e5\u7269\u7be9\u9078\u3002\u671f\u76fc\u7be9\u5f97\u7684\u85e5\u7269\uff0c\u9664\u4e86\u53ef\u6cbb\u7642\u9019\u4e9b\u7a81\u8b8a\u9b5a\u7684\u8840\u7ba1\u589e\u751f\u75c5\u75c7\uff0c\u5c07\u4f86\u4e5f\u53ef\u8207\u672c\u9662\u57fa\u56e0\u9ad4\u4e2d\u5fc3\u5408\u4f5c\uff0c\u7528\u4f86\u7814\u767c\u6cbb\u7642\u4eba\u985e\u76f8\u4f3c\u7684\u75be\u75c5\u3002\u76ee\u524d\uff0c\u5229\u7528\u57fa\u56e0\u8f49\u6b96\u6591\u99ac\u9b5a\u5728\u8840\u7ba1\u7d30\u80de\u7684\u7da0\u87a2\u5149\u86cb\u767d\u8868\u73fe\uff0c \u6211\u5011\u6210\u529f\u7684\u5206\u96e2\u51fa\u6578\u500b\u5f71\u97ff\u8840\u7ba1\u518d\u751f\u7684\u539f\u59cb\u7a81\u8b8a\u7a2e(reg6, dac, prp )\u3002\u6211\u5011\u5c07\u5229\u7528\u7a81\u8b8a\u7a2e\u9032\u884c\u8840\u7ba1\u518d\u751f\u6216\u8840\u7ba1\u986f\u578b\u77ef\u6b63\u4f86\u7be9\u9078\u85e5\u7269\uff0c\u9577\u671f\u76ee\u6a19\u662f\u958b\u767c\u51fa\u65b0\u5316\u5b78\u7269\u7528\u4f86\u6cbb\u7642\u8840\u7ba1\u75be\u75c5\u6216\u764c\u75c7\u3002
\n \u6709\u9452\u65bc\u5efa\u7acb\u5feb\u901f\u907a\u50b3\u53ca\u85e5\u7269\u7be9\u9078\u7684\u810a\u690e\u52d5\u7269\u6a21\u5f0f\u7684\u5fc5\u8981\u6027\uff0c\u6211\u5011\u5df2\u6295\u8cc7\u8a2d\u7acb\u4e00\u5957\u5168\u65b0\u8a2d\u5099\u81f4\u529b\u65bc\u6591\u99ac\u9b5a\u5316\u5b78\u7a81\u8b8a\u7684\u7814\u7a76\u3002\u5305\u542b\u7279\u6b8a\u8a2d\u5099\u7684\u9b5a\u623f\uff0c\u7a81\u8b8a\u8a98\u767c\u5ba4\uff0c\u53ca\u986f\u5fae\u93e1\u5ba4\u3002\u990a\u6b96\u5340\u8a2d\u7acb\u6578\u5957\u7279\u6b8a\u8a2d\u8a08\u4e4b\u6591\u99ac\u9b5a\u990a\u6b96\u7f38\u67b6\uff0c\u53ef\u5bb9\u7d0d15,000\u96bb\u9b5a\u3002\u91cd\u8981\u7684\u662f\u9019\u990a\u6b96\u7f38\u67b6\u7684\u8a2d\u8a08\uff0c\u914d\u6709\u5c0f\u9b5a\u7f38\u4ee5\u5229\u7a81\u8b8a\u7be9\u9078\u3002\u6211\u5011\u53c8\u5229\u7528\u9ad8\u58d3\u5668\u4f86\u4f5c\u65b0\u5f0f\u7a81\u8b8a\u7be9\u9078\u65b9\u6cd5\u3002\u6b64\u65b9\u6cd5\u6bd4\u50b3\u7d71\u65b9\u6cd5\u6e1b\u77ed\u4e00\u4ee3\u990a\u6b96\u6642\u9593\uff0c\u4fbf\u5efa\u7acbhomozygous\u7684\u8b8a\u7a2e\u9b5a\uff0c\u4e26\u6e1b\u5c11\u6240\u9700\u7684\u990a\u6b96\u7a7a\u9593\u3002\u7a81\u8b8a\u8a98\u767c\u5ba4\u8a2d\u5728\u9b5a\u623f\u5c0d\u9762\uff0c\u4f46\u537b\u5b8c\u5168\u9694\u96e2\u3002\u4e0d\u4f46\u56b4\u683c\u7ba1\u5236\u9032\u51fa\u4eba\u54e1\uff0c\u5c0d\u65bc\u64cd\u4f5cENU mutagenesis\u4e4b\u5b89\u5168\u9632\u8b77\u4ea6\u56b4\u683c\u8981\u6c42\u3002
\n \u53e6\u5916\uff0c\u6211\u5011\u4e5f\u8a2d\u7acb\u4e00\u5957\u5b8c\u5099\u4e14\u5148\u9032\u7684\u4eba\u985e\u539f\u751f\u8840\u764c\u8001\u9f20\u52d5\u7269\u6a21\u5f0f\uff0c\u5df2\u7d93\u61c9\u7528\u5728\u6d3b\u9ad4\u5167\u7814\u7a76\u8840\u764c\u5e79\u7d30\u80de\u53ca\u6e2c\u8a66\u65b0\u85e5\u7684\u7642\u6548\u3002\u76ee\u524d\u5df2\u6709\u5f88\u591a\u7a2e\u4e0d\u540c\u7684\u8840\u764c\u7d30\u80de\uff0c\u7372\u5f97\u9ad8\u6210\u529f\u7387\u7684\u79fb\u690d(\u8001\u9f20\u9aa8\u9ad3\u7d30\u80de84.9 \u00b1 2.9 %\u90fd\u662f\u4eba\u985e\u7684\u8840\u764c)\u3002\u5927\u9ad4\u4f86\u8aaa\uff0c\u9019\u4e9b\u816b\u7624\u7684\u767c\u751f\u5728\u56db\u5230\u4e94\u9031\u79fb\u690d\u5f8c\u7684\u8001\u9f20\u7684\u8840\u6db2\u88e1\u662f\u53ef\u88ab\u5bdf\u89ba\u7684\uff0c42 \u00b1 4\u5929\u5de6\u53f3\u4fbf\u53ef\u770b\u51fa\u7d50\u679c\u3002\u4eba\u985e\u7684\u8840\u764c\u7d30\u80de\u5728\u8001\u9f20\u9ad4\u5167\u7e41\u6b96\u589e\u52a0\u4e00\u767e\u500d\u3002\u53e6\u5916\uff0c\u8840\u764c\u53ef\u4ee5\u9023\u7e8c\u8f49\u79fb\u81f3\u5176\u4ed6\u7684\u8001\u9f20\u597d\u5e7e\u4ee3\u3002\u6211\u5011\u7684\u7814\u7a76\uff0c\u8b49\u5be6\u57fa\u56e0\u7684\u8868\u73fe\u5728\u7570\u7a2e\u79fb\u690d\u6a21\u5f0f\u8ddf\u75c5\u4eba\u8eab\u4e0a\u53d6\u5f97\u7684\u539f\u751f\u8840\u764c\u6a23\u672c\u5b8c\u5168\u4e00\u6a23\u3002<\/p>\n
\uff08\u4e8c\uff09\u52d5\u7269\u74b0\u5883\u9069\u61c9\u6a5f\u5236\u7684\u6574\u5408\u6027\u7814\u7a76<\/p>\n
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