{"id":19136,"date":"2019-07-04T00:03:21","date_gmt":"2019-07-03T16:03:21","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=19136"},"modified":"2021-08-04T11:35:40","modified_gmt":"2021-08-04T03:35:40","slug":"%e5%85%b5%e5%88%86%e4%ba%8c%e8%b7%af%ef%bc%81%e7%99%bb%e9%9d%a9%e7%97%85%e6%af%92%e4%be%b5%e7%95%a5%e4%ba%ba%e9%ab%94%e7%9a%84%e9%97%9c%e9%8d%b5%e7%b4%b0%e8%83%9e%ef%bc%9a%e8%a1%80%e5%b0%8f%e6%9d%bf","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/19136\/","title":{"rendered":"\u5175\u5206\u4e8c\u8def\uff01\u767b\u9769\u75c5\u6bd2\u4fb5\u7565\u4eba\u9ad4\u7684\u95dc\u9375\u7d30\u80de\uff1a\u8840\u5c0f\u677f"},"content":{"rendered":"<p>\u611f\u67d3\u767b\u9769\u71b1\u6642\u4eba\u9ad4\u6703\u7522\u751f\u767c\u708e\u53cd\u61c9\uff0c\u5982\u767c\u71d2\u3001\u5192\u75b9\uff0c\u751a\u81f3\u662f\u5668\u5b98\u640d\u50b7\uff0c\u4f46\u708e\u75c7\u7684\u767c\u751f\u6a5f\u5236\u4e26\u4e0d\u6e05\u695a\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3<a href=\"http:\/www.genomics.sinica.edu.tw\/index.php\/tw\/hsieh-shie-liang\"><strong>\u8b1d\u4e16\u826f\u7279\u8058\u7814\u7a76\u54e1<\/strong><\/a>\u7684\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0c\u767b\u9769\u75c5\u6bd2\uff08dengue virus\uff09\u6703\u523a\u6fc0\u8840\u5c0f\u677f\u7522\u751f\u80de\u5916\u56ca\u6ce1\uff08\u53c8\u7a31\u80de\u5916\u9ad4\uff09<sup>1<\/sup>\uff0c\u9032\u800c\u653b\u64ca\u767d\u8840\u7403\uff0c\u5c0e\u81f4\u767c\u708e\u75c5\u75c7\u3002\u7814\u7a76\u5718\u968a\u64da\u6b64\u7814\u767c\u6297\u9ad4\uff0c\u6210\u529f\u5c07\u611f\u67d3\u767b\u9769\u75c5\u6bd2\u7684\u5c0f\u9f20\u5b58\u6d3b\u7387\u63d0\u5347\u81f390%\u3002\u7814\u7a76\u6210\u679c\u5df2\u65bc6\u67083\u65e5\u520a\u767b\u65bc\u570b\u969b\u671f\u520a\u300a\u81ea\u7136\u901a\u8a0a\u300b\uff08<em>Nature Communications<\/em>\uff09\u3002<\/p>\n<p>\u8b1d\u4e16\u826f2008\u5e74\u7684\u7814\u7a76\u5373\u6307\u51fa\uff0c\u767b\u9769\u75c5\u6bd2\u4fb5\u5165\u9ad4\u5167\u5f15\u767c\u75c5\u75c7\u8207\u5de8\u566c\u7d30\u80de\uff08\u4e00\u7a2e\u767d\u8840\u7403\uff0cmacrophage\uff09\u8868\u9762\u7684\u86cb\u767d\u8cea\u53d7\u9ad4C\u578b\u51dd\u96c6\u7d20CLEC5A\u6709\u95dc\u3002\u6b64\u6b21\u8207\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u535a\u58eb\u5f8c\u7814\u7a76\u54e1<strong>\u5b8b\u4f69\u73ca<\/strong>\u5171\u540c\u7814\u7a76\u5247\u9032\u4e00\u6b65\u767c\u73fe\uff0c\u53e6\u4e00\u500b\u767b\u9769\u75c5\u6bd2\u4fb5\u7565\u7684\u95dc\u9375\uff1a\u8840\u5c0f\u677f\u4e0a\u7684C\u578b\u51dd\u96c6\u7d20CLEC2\u3002<\/p>\n<p>\u7814\u7a76\u767c\u73fe\uff0c\u767b\u9769\u75c5\u6bd2\u5165\u4fb5\u4eba\u9ad4\u5f8c\u6703\u7d93\u7531CLEC2\uff0c\u523a\u6fc0\u8840\u5c0f\u677f\u91cb\u653e\u80de\u5916\u56ca\u6ce1\uff0c\u518d\u85c9\u7531\u56ca\u6ce1\u653b\u64ca\u5de8\u566c\u7d30\u80de\u4ee5\u53ca\u55dc\u4e2d\u6027\u767d\u8840\u7403\u4e0a\u7684CLEC5A\u4ee5\u53caTLR-2\u53d7\u9ad4\u3002\u5c0e\u81f4\u4e8c\u7a2e\u767b\u9769\u51fa\u8840\u71b1\u7684\u9014\u5f91\uff0c\u4e00\u70ba\u4fc3\u4f7f\u5de8\u566c\u7d30\u80de\u7522\u751f\u66f4\u591a\u7d30\u80de\u6fc0\u7d20\uff0c\u5f15\u767c\u7d30\u80de\u6fc0\u7d20\u98a8\u66b4<sup>2<\/sup>\u3002\u4e8c\u70ba\u6d3b\u5316\u55dc\u4e2d\u6027\u767d\u8840\u7403\uff0c\u89f8\u767c\u55dc\u4e2d\u6027\u767d\u8840\u7403\u80de\u5916\u6355\u6349\u7db2 (NETs)<sup>3<\/sup>\uff0c\u640d\u5bb3\u8eab\u9ad4\u5668\u5b98\uff0c\u9020\u6210\u81ea\u9ad4\u514d\u75ab\u75c5\u75c7\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u5960\u57fa\u65bc\u8b1d\u4e16\u826f2008\u5e74\u7684\u7814\u7a76\u767c\u73fe\uff0c\u767b\u9769\u75c5\u6bd2\u5165\u4fb5\u4eba\u9ad4\u5f8c\uff0c\u7d93\u7531CLEC5A\uff0c\u9664\u4e86\u6703\u5f15\u767c\u9ad4\u5167\u7684\u7d30\u80de\u6fc0\u7d20\u98a8\u66b4\u5916\uff0c\u9ad4\u5167\u4e5f\u6703\u7570\u5e38\u51fa\u8840\u3002\u7576\u6642\u7814\u767c\u7684\u6297\u9ad4\u5c07\u611f\u67d3\u767b\u9769\u75c5\u6bd2\u7684\u5c0f\u9f20\u5b58\u6d3b\u7387\u5f9e0\u63d0\u5347\u523050%\uff0c\u4f46\u6cbb\u7642\u6548\u679c\u59cb\u7d42\u7121\u6cd5\u518d\u7a81\u7834\u3002<\/p>\n<p>\u7531\u65bc\u767c\u73fe\u53e6\u4e00\u689d\u5165\u4fb5\u9014\u5f91\uff0c\u7814\u7a76\u5718\u968a\u9042\u5728\u5c0f\u9f20\u5be6\u9a57\u4e2d\uff0c\u4f7f\u7528TLR2\u6297\u9ad4\u540c\u6642\u963b\u65b7CLEC5A\u4ee5\u53caTLR2\u8a0a\u865f\u3002\u7814\u7a76\u767c\u73fe\uff0c\u6b64\u65b9\u6cd5\u4e0d\u50c5\u6709\u6548\u964d\u4f4e\u767b\u9769\u75c5\u6bd2\u5f15\u8d77\u7684\u7d30\u80de\u6fc0\u7d20\u98a8\u66b4\uff0c\u5c0f\u9f20\u5b58\u6d3b\u7387\u4e5f\u5f9e50%\u63d0\u5347\u81f390%\u3002<\/p>\n<p>\u8b1d\u4e16\u826f\u8868\u793a\uff0c\u6b64\u6b21\u767c\u73fe\u5b8c\u6574\u7684\u767b\u9769\u75c5\u6bd2\u5165\u4fb5\u9014\u5f91\uff0c\u4e5f\u8b49\u5be6CLEC5A\u53caTLR2\u65bc\u767b\u9769\u75c5\u6bd2\u5f15\u8d77\u4e4b\u767c\u708e\u53cd\u61c9\u4e2d\u626e\u6f14\u4e86\u91cd\u8981\u7684\u8abf\u63a7\u89d2\u8272\uff0c\u66f4\u767c\u73fe\u300c\u80de\u5916\u56ca\u6ce1\u300d\u7adf\u7136\u6210\u70ba\u767b\u9769\u75c5\u6bd2\u7528\u4f86\u653b\u64ca\u4eba\u9ad4\u7684\u6b66\u5668\u3002\u672a\u4f86\u5c07\u7e7c\u7e8c\u63a2\u7a76\u80de\u5916\u56ca\u6ce1\u5728\u611f\u67d3\u708e\u75c7\u4e2d\u7684\u4f5c\u7528\u6a5f\u8f49\uff0c\u4ee5\u53ca\u81ea\u9ad4\u514d\u75ab\u75be\u75c5\u4ee5\u53ca\u7d44\u7e54\u518d\u751f\u6642\uff0c\u80de\u5916\u56ca\u6ce1\u662f\u5426\u4e5f\u662f\u91cd\u8981\u7684\u8abf\u63a7\u56e0\u5b50\u3002<\/p>\n<p>\u672c\u6587\u7b2c\u4e00\u4f5c\u8005\u70ba\u5b8b\u4f69\u73ca\uff0c\u5171\u540c\u4f5c\u8005\u70ba\u8b1d\u4e16\u826f\u53ca\u81fa\u7063\u5927\u5b78\u85e5\u7406\u6240\u6559\u6388\u9ec3\u5fb7\u5bcc\u3002\u7814\u7a76\u8ad6\u6587\u3008Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A\/TLR2\u3009\u5df2\u520a\u767b\u65bc\uff1a<a href=\"https:\/www.nature.com\/articles\/s41467-019-10360-4\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/www.nature.com\/articles\/s41467-019-10360-4<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-19137 aligncenter\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/1-2-s-1024x733.jpg\" alt=\"\" width=\"800\" height=\"573\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/1-2-s-1024x733.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/1-2-s-300x215.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/1-2-s-768x550.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/1-2-s-1080x773.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/1-2-s.jpg 1200w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/1-2-s-693x496.jpg 693w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"text-align: right;\">\uff08\u6587\uff1a\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u3001\u79d8\u66f8\u8655\uff1b\u7167\u7247\uff1a\u8cc7\u8a0a\u8655\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><sup>1<\/sup> \u80de\u5916\u56ca\u6ce1\uff08extracellular vesicles\uff09\uff1a\u7d30\u80de\u6392\u51fa\u4e4b\u7269\u8cea\uff0c\u904e\u53bb\u66fe\u88ab\u8996\u70ba\u7121\u4f5c\u7528\u7684\u7d30\u80de\u6b98\u9ab8\u3002\u56ca\u6ce1\u4e2d\u5305\u8986\u8457\u7d30\u80de\u5c08\u6709\u7684RNA\u3001\u86cb\u767d\uff0c\u53ef\u4ee5\u5f71\u97ff\u5176\u4ed6\u7d30\u80de\u7684\u751f\u7406\u529f\u80fd\u3002\u76f4\u5f91100 nm\u7a31\u70ba\u5fae\u56ca\u6ce1\uff08microvesicles\uff09\uff1b\u76f4\u5f91&lt;100 nm\u7684\u7a31\u70ba\u80de\u5916\u9ad4\uff08exosomes\uff09\u3002<\/p>\n<p><sup>2<\/sup>\u00a0\u7d30\u80de\u6fc0\u7d20\u98a8\u66b4\uff08cytokine storm\uff09\uff1a\u8eab\u9ad4\u53d7\u5230\u75c5\u539f\u83cc\u611f\u67d3\u5f8c\u6703\u7522\u751f\u767c\u708e\u53cd\u61c9\uff0c\u4f46\u904e\u5ea6\u7684\u767c\u708e\u53cd\u61c9\u6703\u5f15\u767c\u5927\u91cf\u7d30\u80de\u6fc0\u7d20\u7684\u7522\u751f\uff0c\u5c0e\u81f4\u514d\u75ab\u53cd\u61c9\u5931\u63a7\uff0c\u9020\u6210\u5668\u5b98\u7684\u640d\u50b7\u53ca\u8870\u7aed\u3002<\/p>\n<p><sup>3<\/sup>\u00a0\u55dc\u4e2d\u6027\u767d\u8840\u7403\u80de\u5916\u6355\u6349\u7db2\uff08Neutrophil Extracellular Trap, NET\uff09\uff1a\u7576\u4fb5\u5165\u4eba\u9ad4\u7684\u7d30\u83cc\u6578\u91cf\u592a\u591a\uff0c\u55dc\u4e2d\u6027\u767d\u8840\u7403\u7121\u6cd5\u85c9\u7531\u541e\u566c\u7d30\u83cc\u4f86\u6291\u5236\u7d30\u83cc\u5165\u4fb5\u6642\uff0c\u6703\u50be\u5168\u529b\u81a8\u8139\u7d30\u80de\u6838\uff0c\u91cb\u51fa\u53bb\u6c27\u6838\u7cd6\u6838\u9178\uff08DNA\uff09\u3002\u56e0DNA\u662f\u5e36\u8ca0\u96fb\u8377\u9ecf\u6027\u5f88\u5f37\u7684\u7269\u8cea\uff0c\u596e\u529b\u4e00\u640f\u4fbf\u5982\u5929\u7f85\u5730\u7db2\uff0c\u5c07\u7d30\u83cc\u4e00\u7db2\u6253\u76e1\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u611f\u67d3\u767b\u9769\u71b1\u6642\u4eba\u9ad4\u6703\u7522\u751f\u767c\u708e\u53cd\u61c9\uff0c\u5982\u767c\u71d2\u3001\u5192\u75b9\uff0c\u751a\u81f3\u662f\u5668\u5b98\u640d\u50b7\uff0c\u4f46\u708e\u75c7\u7684\u767c\u751f\u6a5f\u5236\u4e26\u4e0d\u6e05\u695a\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u8b1d\u4e16 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19137,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19136"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=19136"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19136\/revisions"}],"predecessor-version":[{"id":19240,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/19136\/revisions\/19240"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/19137"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=19136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=19136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=19136"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}