{"id":18572,"date":"2019-06-20T00:00:11","date_gmt":"2019-06-19T16:00:11","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=18572"},"modified":"2021-08-04T13:19:17","modified_gmt":"2021-08-04T05:19:17","slug":"%e7%99%bc%e7%8f%be%e4%ba%ba%e9%a1%9edna%e8%81%9a%e5%90%88%e9%85%b6%ce%bc%e5%8f%af%e5%88%a9%e7%94%a8%e9%8c%b3%e9%9b%a2%e5%ad%90%e5%be%aa%e9%9d%9e%e5%85%b8%e5%9e%8b%e8%b7%af%e5%be%91%e9%80%b2%e8%a1%8c","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/18572\/","title":{"rendered":"\u767c\u73fe\u4eba\u985eDNA\u805a\u5408\u9176\u03bc\u53ef\u5229\u7528\u9333\u96e2\u5b50\u5faa\u975e\u5178\u578b\u8def\u5f91\u9032\u884c\u53cd\u61c9"},"content":{"rendered":"<p>\u672c\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u7279\u8058\u7814\u7a76\u54e1\u8521\u660e\u9053\u9662\u58eb\u8207\u7814\u7a76\u526f\u6280\u5e2b\u5433\u6587\u6649\u535a\u58eb\u6240\u9818\u5c0e\u7684DNA\u805a\u5408\u9176\u5718\u968a\u65bc\u4e94\u6708\u4e8c\u5341\u4e5d\u65e5\u5728\u300a\u7f8e\u570b\u5316\u5b78\u5b78\u6703\u671f\u520a\u300b\uff08Journal 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525px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-18574\" class=\"wp-image-18574\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/3-2-2.jpg\" alt=\"\" width=\"515\" height=\"600\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/3-2-2.jpg 764w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/06\/3-2-2-258x300.jpg 258w\" sizes=\"(max-width: 515px) 100vw, 515px\" \/><p id=\"caption-attachment-18574\" class=\"wp-caption-text\">\u5716\u8aaa\uff1a\u4eba\u985eDNA\u805a\u5408\u9176Pol \u03bc\u53ef\u5728\u9333\u96e2\u5b50\u7684\u5e6b\u52a9\u4e0b\uff0c\u9032\u884c\u975e\u5178\u578b (non-canonical) \u7684\u50ac\u5316\u53cd\u61c9\uff1a\u5728\u7d50\u5408DNA\u524d\uff0c\u9810\u5148\u4ee5\u5177\u6d3b\u6027\u7684\u69cb\u578b\u7d50\u5408\u9333\u2022\u53bb\u6c27\u6838\u82f7\u9178 (Mn\u2022dNTP)\u3002\u5728\u4e00\u822c\u9382\u96e2\u5b50\u7684\u60c5\u6cc1\u4e0b\uff0cPol 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\u5e74\u975e\u6d32\u8c6c\u761f\u75c5\u6bd2 Pol X \u4e4b JACS\u8ad6\u6587\u30012016\u5e74\u4eba\u985e Pol \u03bc \u4e4bJACS \u8ad6\u6587\u4ee5\u53ca2017\u5e74 Nature Reviews Chemistry\u7d9c\u8ff0\u8ad6\u6587\u5f8c\u7684\u53e6\u4e00\u91cd\u5927\u6210\u679c\u5831\u5c0e\u3002\u672c\u7814\u7a76\u7531\u672c\u9662\u3001\u79d1\u6280\u90e8\u8207\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u652f\u6301\u3002<\/p>\n<p>\u6b64\u8ad6\u6587\u7684\u6a19\u984c\u70ba \u201cHuman DNA Polymerase \u03bc Can Use a Noncanonical Mechanism for Multiple Mn2+-mediated Functions\u201d\u3002<br \/>\n\u8ad6\u6587\u7db2\u7ad9 : https:\/pubs.acs.org\/doi\/10.1021\/jacs.9b01741<br \/>\n\u4f5c\u8005\u7fa4: Chang YK, Huang YP, Liu XX, Ko TP, Bessho Y, Kawano Y, Maestre-Reyna M, Wu WJ*, Tsai 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