{"id":18523,"date":"2019-06-20T00:00:44","date_gmt":"2019-06-19T16:00:44","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=18523"},"modified":"2021-08-04T13:16:26","modified_gmt":"2021-08-04T05:16:26","slug":"%e7%95%b6%e9%ab%94%e5%85%a7%e7%9a%84%e6%b2%b9%e9%9b%bb%e6%b7%b7%e5%92%8c%e8%bb%8a%e3%80%8c%e9%9b%bb%e6%b1%a0%e5%a3%9e%e4%ba%86%e3%80%8d%ef%bc%81%e9%81%8b%e5%8b%95%e7%a5%9e%e7%b6%93%e5%85%83%e9%80%80","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/18523\/","title":{"rendered":"\u7576\u9ad4\u5167\u7684\u6cb9\u96fb\u6df7\u548c\u8eca\u300c\u96fb\u6c60\u58de\u4e86\u300d\uff01\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316"},"content":{"rendered":"

\u904b\u52d5\u795e\u7d93\u5143\u7814\u7a76<\/strong><\/p>\n

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\u9084\u8a18\u5f97\u300c\u6f38\u51cd\u4eba\u51b0\u6876\u8003\u9a57\u300d\u55ce\uff1f\u91d1\u57ce\u6b66\u6dcb\u4e0b\u51b0\u6c34\u7684\u701f\u7051\u4ee4\u4eba\u96e3\u4ee5\u5fd8\u61f7\uff0c\u4f46\u672c\u6587\u60f3\u5c07\u4f60\u7684\u6ce8\u610f\u529b\u8f49\u79fb\u5230\u6f38\u51cd\u75c7\u672c\u8eab\u3002\u4e2d\u7814\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u7684\u9673\u4fca\u5b89\u52a9\u7814\u7a76\u54e1\uff0c\u8207\u5718\u968a\u5f9e\u767c\u80b2\u751f\u7269\u5b78\u7684\u89d2\u5ea6\uff0c\u5c0b\u627e\u300c\u6703\u9000\u5316\u300d\u548c\u300c\u4e0d\u6703\u9000\u5316\u300d\u7684\u904b\u52d5\u795e\u7d93\u5143\u5728\u57fa\u56e0\u8868\u73fe\u4e0a\u54ea\u88e1\u4e0d\u540c\uff0c\u5e0c\u671b\u672a\u4f86\u6709\u52a9\u65bc\u6f38\u51cd\u75c7\u7684\u7cbe\u6e96\u91ab\u7642\u3002<\/div>\n<\/div>\n<\/div>\n
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\u5148\u4f86\u9032\u884c\u773c\u529b\u8003\u9a57\uff0c\u4e0b\u5716\u91ce\u751f\u578b\u5c0f\u9f20\u80da\u80ce\u3001 \u985e ALS (\u6f38\u51cd\u75c7)\u6a21\u5f0f\u5c0f\u9f20\u80da\u80ce\uff0c\u770b\u5f97\u51fa\u300c\u904b\u52d5\u795e\u7d93\u5143\u300d\u54ea\u88e1\u4e0d\u540c\u55ce\uff1f<\/p>\n

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\"\"

\u5169\u7a2e\u5c0f\u9f20\u80da\u80ce\u7684\u904b\u52d5\u795e\u7d93\u5143\u6bd4\u8f03 (\u4e2d\u9593\u9577\u9577\u3001\u5c3e\u7aef\u4f38\u51fa\u8a31\u591a\u6a39\u7a81\u7684\u90a3\u4e00\u689d)\u3002 \u5716\u7247\u4f86\u6e90\u2502Crucial Cluster: MicroRNAs Keep Motor Neurons Alive<\/p><\/div>\n<\/div>\n

 <\/p>\n

\u5de6\u5716\u7684\u91ce\u751f\u578b\u5c0f\u9f20\uff0c\u904b\u52d5\u795e\u7d93\u5143\u8ef8\u7a81\u5065\u5eb7\u7c97\u58ef\uff0c\u53ef\u4ee5\u7262\u7262\u6293\u4f4f\u808c\u8089\u7d30\u80de\uff0c\u4e26\u63a7\u5236\u56db\u80a2\u4f5c\u51fa\u5927\u8166\u547d\u4ee4\u7684\u3001\u6216\u53cd\u5c04\u6027\u7684\u52d5\u4f5c\u3002\u4f46\u53f3\u5716\u7684\u985e ALS \u6a21\u5f0f\u5c0f\u9f20\uff0c\u904b\u52d5\u795e\u7d93\u4e0b\u7aef\u7684\u6a39\u7a81\u8b8a\u5c11\u4e86\uff0c\u7121\u6cd5\u7262\u7262\u6293\u4f4f\u808c\u8089\u7d30\u80de\uff0c\u56db\u80a2\u4e5f\u8ddf\u8457\u840e\u7e2e\u3001\u4e0d\u807d\u4f7f\u559a\u3002<\/p>\n

\u9019\u500b\u300c\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u300d\u7684\u60c5\u6cc1\u6703\u767c\u751f\u5728\u5c0f\u9f20\u8eab\u4e0a\uff0c\u4e5f\u6703\u767c\u751f\u5728\u4eba\u985e\u8eab\u4e0a\u3002\u300c\u6f38\u51cd\u75c7\u300d\u5c31\u662f\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u5c0e\u81f4\u7684\u75be\u75c5\uff0c\u6703\u5f9e\u56db\u80a2\u958b\u59cb\u7121\u529b\uff0c\u6f38\u6f38\u6f14\u9032\u81f3\u5168\u8eab\u808c\u8089\u840e\u7e2e\u3001\u547c\u5438\u8870\u7aed\u3002<\/p>\n

 <\/p>\n

\"\"

\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5 (motorneuron diseases) \u4fd7\u7a31\u300c\u6f38\u51cd\u75c7\u300d\uff0c\u5176\u7279\u6027\u8207\u75c7\u72c0\u767c\u5c55\u3002 \u8cc7\u6599\u4f86\u6e90\u2502\u4e2d\u83ef\u6c11\u570b\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u75c5\u53cb\u5354\u6703(\u6f38\u51cd\u4eba\u5354\u6703) \u5716\u8aaa\u91cd\u88fd\u2502\u6797\u5a77\u5afb\u3001\u5f35\u8a9e\u8fb0<\/p><\/div>\n<\/div>\n

 <\/p>\n

\u5728\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u5206\u985e\u4e2d\uff0c\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7 (SMA) \u662f\u907a\u50b3\u6027\u75be\u75c5\uff0c\u597d\u767c\u65bc\u5b30\u5b69\u6642\u671f\uff0c\u81f4\u75c5\u6a5f\u8f49\u662f\u56e0\u70ba\u7238\u7238\u5abd\u5abd\u540c\u6642\u5e36\u4e86\u4e00\u5957\u6709\u7f3a\u9677\u7684 SMN1 \u57fa\u56e0\u3002\u7576 SMN1 \u57fa\u56e0\u6709\u7f3a\u9677\u6642\u6703\u8b93\u904b\u52d5\u795e\u7d93\u5143\u6b7b\u4ea1\uff0c\u901a\u5e38\u5c0f\u670b\u53cb\u516d\u500b\u6708\u5927\u61c9\u8a72\u53ef\u4ee5\u5750\u8d77\u4f86\uff0c\u4f46\u6709\u4e9b\u5b30\u5152\u7684\u7236\u6bcd\u537b\u767c\u73fe\u5c0f\u5bf6\u8c9d\u6c92\u8fa6\u6cd5\u5750\u8d77\u6642\uff0c\u6aa2\u67e5\u5f8c\u624d\u77e5\u9053\u539f\u4f86\u662f\u810a\u9ad3\u6027\u808c\u8089\u840e\u7e2e\u75c7 (SMA)\u3002<\/p>\n

\u800c\u5176\u4ed6\u7684\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\uff0c\u5305\u542b\u808c\u840e\u7e2e\u6027\u810a\u9ad3\u5074\u7d22\u786c\u5316\u75c7 (ALS) \u7b49\uff0c\u96d6\u7136\u4e5f\u662f\u7531\u65bc\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u6b7b\u4ea1\uff0c\u4f46\u5c1a\u6709\u4e5d\u6210\u75c5\u4eba\u767c\u75c5\u7684\u539f\u56e0\u662f\u4e0d\u6e05\u695a\u7684\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n

\n

\u70ba\u4ec0\u9ebc\u904b\u52d5\u795e\u7d93\u5143\u6703\u9000\u5316\uff1f\u70ba\u4f55\u5f9e\u56db\u80a2\u958b\u59cb\uff1f\u70ba\u4f55\u6709\u4e9b\u808c\u8089\u4e0d\u53d7\u5f71\u97ff\uff1f\u79d1\u5b78\u5bb6\u5c1a\u5728\u7406\u89e3\u4e2d\u3002<\/strong><\/h4>\n

 <\/p><\/blockquote>\n

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\u4ec0\u9ebc\u4f7f\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\uff1f<\/b><\/strong><\/h2>\n<\/div>\n<\/div>\n
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\u5728\u300a\u611b\u7684\u842c\u7269\u8ad6\u300b\u96fb\u5f71\u4e2d\uff0c\u4e3b\u89d2\u970d\u91d1\u535a\u58eb\u5f9e\u56db\u80a2\u958b\u59cb\u9000\u5316\uff0c\u521d\u671f\u662f\u624b\u90e8\u808c\u8089\u62ff\u4e0d\u7a69\u8336\u676f\uff0c\u6f38\u6f38\u96d9\u817f\u808c\u8089\u7121\u529b\u3001\u8dcc\u5012\u3002\u4f46\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7d71\u8f03\u4e0d\u53d7\u5f71\u97ff\uff0c\u751f\u4e0b\u4e86\u53ef\u611b\u7684\u5b69\u5b50\u5011\uff0c\u4ed6\u5c0d\u670b\u53cb\u7b11\u8aaa\u662f\u300c\u53e6\u4e00\u500b\u5168\u81ea\u52d5\u7684\u7cfb\u7d71\u300d\u3002\u76f4\u5230\u6700\u5f8c\uff0c\u970d\u91d1\u535a\u58eb\u63a7\u5236\u773c\u7403\u7684\u808c\u8089\u4ecd\u80fd\u6b63\u5e38\u904b\u4f5c\uff0c\u8b93\u4ed6\u53ef\u4ee5\u7528\u773c\u7403\u64cd\u63a7\u9375\u76e4\u8aaa\u8a71\u3001\u66f8\u5beb\u3002<\/p>\n

\"\"

\u300a\u611b\u7684\u842c\u7269\u8ad6\u300b\u96fb\u5f71\u4e2d\uff0c\u4e3b\u89d2\u970d\u91d1\u535a\u58eb\u5f9e\u56db\u80a2\u904b\u52d5\u795e\u7d93\u958b\u59cb\u9000\u5316\uff0c\u521d\u671f\u7121\u6cd5\u63a7\u5236\u624b\u90e8\u808c\u8089\u5beb\u5b57\u3002 \u5716\u7247\u4f86\u6e90\u2502\u3010\u611b\u7684\u842c\u7269\u8ad6\u3011\u9810\u544a \u2013 \u74b0\u7403\u5f71\u7247\u5b98\u65b9\u983b\u9053<\/p><\/div>\n<\/div>\n<\/div>\n

 <\/p>\n

\u4e2d\u7814\u9662\u5206\u5b50\u751f\u7269\u6240\u7684\u9673\u4fca\u5b89\u5718\u968a\u5c08\u7cbe\u65bc\u767c\u80b2\u751f\u7269\u5b78\uff0c\u95b1\u8b80\u904b\u52d5\u795e\u7d93\u5143\u75be\u75c5\u7684\u6587\u737b\u3001\u548c\u91ab\u751f\u8a0e\u8ad6\uff0c\u767c\u73fe\u810a\u9ad3\u904b\u52d5\u795e\u7d93\u5143\u5728\u767c\u80b2\u6642\u90fd\u662f\u5f9e\u540c\u6a23\u7684\u524d\u9a45\u7d30\u80de\u5206\u5316\u800c\u4f86\uff0c\u4f46\u300c\u56db\u80a2\u300d\u7684\u904b\u52d5\u795e\u7d93\u5143\u6703\u5148\u767c\u75c5\uff0c\u800c\u63a7\u5236\u773c\u7403\u548c\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7d71\u7684\u904b\u52d5\u795e\u7d93\u5143\u4ecd\u80fd\u6b63\u5e38\u904b\u4f5c\u3002<\/p>\n

\u300c\u662f\u5426\u4e0d\u540c\u7684\u904b\u52d5\u795e\u7d93\u5143\u4e9e\u578b (subtype) \uff0c\u6703\u6709\u4e0d\u540c\u57fa\u56e0\u8868\u73fe\u7684\u5dee\u7570\uff0c\u5c0e\u81f4\u9019\u7a2e\u767c\u75c5\u7a0b\u5ea6\u7684\u4e0d\u7b49\uff1f\u300d\u9673\u4fca\u5b89\u5718\u968a\u5f9e\u9019\u88e1\u958b\u59cb\u601d\u8003\uff0c\u4e26\u5c07\u5c0f\u9f20\u80da\u80ce\u5e79\u7d30\u80de (ES cell) \u5206\u5316\u6210\u5404\u5f0f\u7684\u904b\u52d5\u795e\u7d93\u5143\u4e9e\u578b\uff0c\u518d\u5c07\u5404\u7a2e\u4e9e\u578b\u9032\u884c\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff0c\u6aa2\u67e5\u57fa\u56e0\u8868\u73fe\u54ea\u88e1\u4e0d\u540c\u3002<\/p>\n

 <\/p>\n

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\u5c0f\u9f20\u80da\u80ce\u5e79\u7d30\u80de (ES cell) \u5728\u57f9\u990a\u76bf\u4e2d\uff0c\u6703\u6839\u64da\u5916\u5728\u8a0a\u865f\u7684\u6fc3\u5ea6\u9ad8\u4f4e\u3001\u751f\u9577\u56e0\u5b50\u7684\u5f15\u5c0e\uff0c\u6f14\u7e79\u51fa\u4e0d\u540c\u7684\u904b\u52d5\u795e\u7d93\u5143\u524d\u9a45\u7d30\u80de\uff0c\u4e26\u9032\u4e00\u6b65\u5206\u5316\u6210\u4e0d\u540c\u7684\u4e9e\u578b (subtype) \u3002
\u8cc7\u6599\u4f86\u6e90\u2502\u9673\u4fca\u5b89\u63d0\u4f9b \u5716\u8aaa\u91cd\u88fd\u2502\u6797\u5a77\u5afb\u3001\u5f35\u8a9e\u8fb0<\/p><\/div>\n

 <\/p>\n

\u82e5\u4ee5\u524d\u8b80\u7684\u751f\u7269\u8ab2\u5df2\u5fd8\u5f97\u5dee\u4e0d\u591a\uff0c\u6c92\u95dc\u4fc2\uff0c\u672c\u6587\u5f9e\u4f60\u6211\u9ad4\u5167\u7684 DNA\u3001RNA \u3001\u86cb\u767d\u8cea\u8ffd\u672c\u6eaf\u6e90\uff0c\u5176\u4e2d\u85cf\u8457\u53ef\u80fd\u5f71\u97ff\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u7684\u958b\u95dc\uff1amir-17~92<\/em>\u00a0\u548c PTEN \u3002<\/p>\n

 <\/p>\n

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mir-17~92<\/em>\uff1a\u963b\u6b62\u63a7\u5236\u56db\u80a2\u7684\u904b\u52d5\u795e\u7d93\u7d30\u80de\u51cb\u96f6<\/b><\/strong><\/h2>\n<\/div>\n<\/div>\n
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\u751f\u7269\u9ad4\u5167\u7684\u7d30\u80de\u6838\u4e2d\uff0cDNA \u5c31\u50cf\u5f71\u5370\u6a5f\u4e2d\u7684\u6b63\u672c\uff0c\u6703\u8907\u5370\u51fa\u5e36\u6709\u76f8\u540c\u57fa\u56e0\u8a0a\u606f\u7684 RNA \u3002 RNA \u6709\u5169\u7a2e: \u4e00\u7a2e\u662f\u8ca0\u8cac\u88fd\u9020\u86cb\u767d\u8cea\u7684 mRNA (messenger RNA) \uff0c\u5c31\u50cf\u8981\u628a\u57fa\u56e0\u8a0a\u606f\u50b3\u7d66\u86cb\u767d\u8cea\u7684\u50b3\u8a0a\u5b98\uff1b\u53e6\u4e00\u7a2e\u662f ncRNA (non-coding RNA) \uff0c\u4e0d\u8ca0\u8cac\u88fd\u9020\u86cb\u767d\u8cea\uff0c\u800c\u662f\u76f4\u63a5\u4ee5 RNA \u7684\u8eab\u5206\u4f86\u57f7\u884c\u4efb\u52d9\u3002<\/p>\n

\u6709\u4e00\u4e9b ncRNA \u6703\u5f85\u5728\u7d30\u80de\u6838\u88e1\uff0c\u50cf\u662f\u5f8c\u52e4\u55ae\u4f4d\u88dc\u7d66\u524d\u7dda\u4f5c\u6230\u8cc7\u6e90\u3002\u53e6\u5916\u6709\u4e00\u4e9b ncRNA \u50cf\u662f microRNA \u6703\u76f4\u63a5\u51fa\u6838\uff0c\u5c31\u50cf\u89aa\u8eab\u5230\u524d\u7dda\u51fa\u4efb\u52d9\u7684\u8ecd\u5b98\u3002<\/p>\n

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\u8981\u770b\u66f4\u5b8c\u6574\u7684\u7cbe\u91c7\u6587\u7ae0\uff0c\u8acb\u81f3\u7814\u4e4b\u6709\u7269\u5b98\u7db2\uff1a<\/strong><\/h2>\n

http:\/research.sinica.edu.tw\/motor-neuron-diseases-mir-17-92\/<\/em><\/a><\/h2>\n

\uff08\u8d95\u5feb\u9ede\u9032\u4f86\u5594\uff01\u9084\u6709\u66f4\u591a\u7cbe\u91c7\u5716\u6587\uff01\uff09<\/strong><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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