{"id":18315,"date":"2019-06-06T00:02:58","date_gmt":"2019-06-05T16:02:58","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=18315"},"modified":"2021-08-04T14:15:26","modified_gmt":"2021-08-04T06:15:26","slug":"%e3%80%8c%e8%a7%a3%e5%87%8d%e3%80%8d%e6%96%b0%e7%aa%81%e7%a0%b4%ef%bc%81-%e5%be%ae%e5%9e%8b%e6%a0%b8%e7%b3%96%e6%a0%b8%e9%85%b8%e5%8f%af%e8%a9%95%e4%bc%b0%e3%80%8c%e6%bc%b8%e5%87%8d%e7%97%87%e3%80%8d","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/18315\/","title":{"rendered":"\u300c\u89e3\u51cd\u300d\u65b0\u7a81\u7834\uff01 \u5fae\u578b\u6838\u7cd6\u6838\u9178\u53ef\u8a55\u4f30\u300c\u6f38\u51cd\u75c7\u300d\u767c\u75c5\u98a8\u96aa \u6709\u6f5b\u529b\u4f5c\u70ba\u65b0\u6cbb\u7642\u85e5\u7269"},"content":{"rendered":"

\u7f55\u898b\u75be\u75c5\u300c\u6f38\u51cd\u75c7\u300d\uff08\u5b78\u540d\u70ba\u808c\u840e\u7e2e\u6027\u810a\u9ad3\u5074\u7d22\u786c\u5316\u75c7\uff09\u81f3\u4eca\u9084\u6709\u8a31\u591a\u672a\u89e3\u4e4b\u8b0e\uff0c\u9664\u4e86\u7d04\u4e00\u6210\u75c5\u60a3\u70ba\u5bb6\u65cf\u907a\u50b3\uff0c\u6709\u4e5d\u6210\u60a3\u8005\u7684\u81f4\u75c5\u539f\u56e0\u4ecd\u7136\u4e0d\u660e\u3002<\/p>\n

\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u9673\u4fca\u5b89\u526f\u7814\u7a76\u54e1<\/strong><\/a>\u8207\u7814\u7a76\u5718\u968a\u767c\u73fe\uff0c\u4e00\u7d44\u5fae\u578b\u6838\u7cd6\u6838\u9178\uff08microRNA\uff09\uff0c\u7a31\u4e4b\u70bamir-17~92[1]<\/a>\uff0c\u5728\u56db\u80a2\u904b\u52d5\u795e\u7d93\u5143\u7684\u8868\u73fe\u91cf\u7279\u5225\u9ad8\uff0c\u537b\u5728\u6f38\u51cd\u75c7\u5c0f\u9f20\u767c\u75c5\u524d\u986f\u8457\u6e1b\u5c11\u3002\u6b64\u70ba\u5168\u7403\u9996\u6b21\u767c\u73femir-17~92\u5177\u6709\u4f5c\u70ba\u9810\u6e2c\u6f38\u51cd\u75c7\u767c\u75c5\u7684\u751f\u7269\u6a19\u8a18\uff0c\u53ef\u6539\u5584\u6f38\u51cd\u75c7\u5c0f\u9f20\u75c5\u5fb5\uff0c\u6b64\u5be6\u9a57\u7d50\u679c\u5df2\u7533\u8acb\u5c08\u5229\uff0c\u6709\u52a9\u65bc\u672a\u4f86\u4ee5\u57fa\u56e0\u6cbb\u7642\u6f38\u51cd\u75c7\u6a19\u9776\u85e5\u7269\u7684\u7814\u767c\u3002\u7814\u7a76\u6210\u679c\u5df2\u65bc\u4eca\uff08108\uff09\u5e745\u670830\u65e5\u520a\u767b\u65bc\u570b\u969b\u671f\u520a\u300a\u7d30\u80de\uff1a\u5e79\u7d30\u80de\u300b\uff08Cell Stem Cell<\/em>\uff09<\/strong>\u3002<\/p>\n

\u6f38\u51cd\u75c7\u662f\u4e00\u7a2e\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u5c0e\u81f4\u7684\u75be\u75c5\uff0c\u5f9e\u63a7\u5236\u56db\u80a2\u7684\u904b\u52d5\u795e\u7d93\u5143\u958b\u59cb\u767c\u75c5\u3002\u60a3\u8005\u521d\u671f\u56e0\u70ba\u611f\u5230\u624b\u8173\u7121\u529b\u800c\u5c31\u91ab\uff0c\u4f46\u6b64\u6642\u9ad4\u5167\u7684\u904b\u52d5\u795e\u7d93\u5143\u5df2\u958b\u59cb\u51fa\u554f\u984c\u4e26\u8fc5\u901f\u9000\u5316\uff0c\u77ed\u671f\u5167\u4fbf\u7121\u6cd5\u884c\u8d70\u6216\u9748\u6d3b\u4f7f\u7528\u96d9\u624b\uff0c\u6700\u5f8c\u53ea\u80fd\u6f38\u6f38\u8eba\u81e5\u5728\u8f2a\u6905\u4e2d\uff0c\u5927\u591a\u6b7b\u65bc\u547c\u5438\u8870\u7aed\u3002<\/p>\n

\"\"

\u672c\u9662\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\u9673\u4fca\u5b89\u526f\u7814\u7a76\u54e1<\/p><\/div>\n

 <\/p>\n

mir-17~92 <\/strong>\u548c<\/strong> PTEN[2]<\/a><\/strong>\uff1a\u5f71\u97ff\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u7684\u95dc\u9375<\/strong><\/p>\n

\u672c\u6b21\u767c\u73fe\u7684\u6f38\u51cd\u75c7\u81f4\u75c5\u6a5f\u8f49\uff0c\u5960\u57fa\u65bc\u9673\u4fca\u5b89\u5148\u524d\u7684\u57fa\u790e\u7814\u7a76\u6210\u679c\uff0c\u4ed6\u767c\u73fe\u5c0f\u9f20\u80da\u80ce\u88e1\u7684mir-17~92\u5927\u91cf\u8868\u73fe\u65bc\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u88e1\u63a7\u5236\u56db\u80a2\u808c\u8089\u7684\u904b\u52d5\u795e\u7d93\u5143\u3002\u7531\u65bcPTEN\u86cb\u767d\u8cea\u7d2f\u7a4d\u5728\u904b\u52d5\u795e\u7d93\u5143\u7d30\u80de\u6838\uff0c\u5c0e\u81f4\u7d30\u80de\u9000\u5316\u6b7b\u4ea1\uff1bmir-17~92\u53ef\u6291\u5236PTEN\u86cb\u767d\u8cea\u7684\u8868\u73fe\u91cf\uff0c\u963b\u64cb\u86cb\u767d\u8cea\u9032\u5165\u7d30\u80de\u6838\u4e2d\uff0c\u9032\u800c\u4fdd\u8b77\u904b\u52d5\u795e\u7d93\u5143\u5b58\u6d3b\uff0c\u963b\u6b62\u63a7\u5236\u56db\u80a2\u7684\u904b\u52d5\u795e\u7d93\u7d30\u80de\u51cb\u96f6\u3002<\/p>\n

\u9673\u4fca\u5b89\u7814\u7a76\u5718\u968a\u900f\u904e\u5be6\u9a57\u767c\u73fe\uff0c\u7576\u5c0f\u9f20\u80da\u80ce\u7684\u904b\u52d5\u795e\u7d93\u5143\u5931\u53bbmir-17~92\u6642\uff0c\u56e0\u7121\u6cd5\u6291\u5236PTEN\u7684\u8868\u73fe\u91cf\uff0c\u5c0e\u81f4PTEN\u589e\u9ad8\u4e26\u9032\u5165\u7d30\u80de\u6838\u88e1\uff0c\u9020\u6210\u63a7\u5236\u56db\u80a2\u808c\u8089\u7684\u904b\u52d5\u795e\u7d93\u5143\u6b7b\u4ea1\u3002<\/p>\n

\u672c\u7bc7\u7814\u7a76\u70ba\u9a57\u8b49mir-17~92\u662f\u5426\u4e5f\u5728\u6f38\u51cd\u75c7\u7684\u904b\u52d5\u795e\u7d93\u5143\u9000\u5316\u4e0a\u626e\u6f14\u95dc\u9375\u89d2\u8272\uff0c\u9673\u4fca\u5b89\u63a1\u7528\u591a\u7a2e\u751f\u7269\u6a21\u5f0f\u7cfb\u7d71\u505a\u75c5\u7406\u9a57\u8b49\uff0c\u5305\u62ec\u5c0f\u96de\u80da\u80ce\u3001SOD1G93A [3]<\/a><\/sup>\u6f38\u51cd\u75c7\u5c0f\u9f20\u4ee5\u53ca\u5176\u5e79\u7d30\u80de\u5206\u5316\u4e4b\u904b\u52d5\u795e\u7d93\u5143\u3001\u6f38\u51cd\u75c7\u60a3\u8005\u7684\u8a98\u5c0e\u6027\u591a\u529f\u80fd\u5e79\u7d30\u80de\u6240\u884d\u751f\u4e4b\u904b\u52d5\u795e\u7d93\u5143\uff08iPSC~MNs[4]<\/a>\uff09\u7b49\uff0c\u89c0\u5bdfmir-17~92\u7684\u4f5c\u7528\u8207\u8868\u73fe\u5f8c\uff0c\u5747\u5f97\u5230\u4e00\u81f4\u7684\u7d50\u679c\u3002<\/p>\n

 <\/p>\n

mir-17~92<\/strong>\u53ef\u671b\u61c9\u7528\u65bc\u300c\u6f38\u51cd\u75c7\u300d\u7684\u9810\u6e2c\u8207\u6cbb\u7642<\/strong><\/p>\n

\u9673\u4fca\u5b89\u89e3\u91cb\uff0c\u539f\u672c\u61c9\u8a72\u5927\u91cf\u8868\u73fe\u65bc\u56db\u80a2\u904b\u52d5\u795e\u7d93\u5143\u7684mir-17~92\uff0c\u5728\u6f38\u51cd\u75c7\u5c0f\u9f20\u767c\u75c5\uff08\u56db\u80a2\u904b\u52d5\u795e\u7d93\u5143\u6b7b\u4ea1\uff09\u524d\u6703\u986f\u8457\u6e1b\u5c11\uff0c\u5c0e\u81f4PTEN\u9010\u6f38\u7d2f\u7a4d\u5728\u7d30\u80de\u6838\u4e2d\uff0c\u6700\u5f8c\u7d30\u80de\u9000\u5316\u6b7b\u4ea1\u3002<\/p>\n

\u4ee4\u4eba\u632f\u596e\u7684\u662f\uff0c\u7814\u7a76\u5718\u968a\u5c07SOD1G93A<\/sup>\u6f38\u51cd\u75c7\u5c0f\u9f20\u9ad4\u5167\u7684mir-17~92\u8868\u73fe\u91cf\u63d0\u9ad8\uff0c\u767c\u73fe\u53ef\u4ee5\u5ef6\u7de9\u5c0f\u9f20\u7671\u7613\u7684\u6642\u9593\uff0c\u986f\u8457\u589e\u9032\u5176\u904b\u52d5\u80fd\u529b\uff0c\u5c0f\u9f20\u58fd\u547d\u4e5f\u5e73\u5747\u5ef6\u957714%\u3002<\/p>\n

\u7531\u65bc\u76ee\u524d\u6f38\u51cd\u75c7\u60a3\u8005\u767c\u75c5\u5f8c\u5e73\u5747\u58fd\u547d\u50c5\u4e8c\u81f3\u4e94\u5e74\uff0c\u82e5\u5c07mir-17~92\u7684\u57fa\u56e0\u6cbb\u7642\u61c9\u7528\u65bc\u4eba\u9ad4\u4e0a\uff0c\u53ef\u671b\u70ba\u6f38\u51cd\u75c7\u6cbb\u7642\u5e36\u4f86\u4e00\u9053\u66d9\u5149\u3002\u672c\u7814\u7a76\u767c\u73femir-17~92\u8207\u6f38\u51cd\u75c7\u767c\u75c5\u7684\u95dc\u806f\u6027\uff0c\u4e5f\u70ba\u300c\u89e3\u51cd\u300d\u6f38\u51cd\u75c7\u7684\u81f4\u75c5\u6a5f\u5236\u5f80\u524d\u63a8\u9032\u4e86\u4e00\u6b65\u3002<\/p>\n

\u6b64\u7814\u7a76\u7531\u672c\u9662\u3001\u570b\u885b\u9662\u4ee5\u53ca\u79d1\u6280\u90e8\u652f\u6301\u3002\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u70ba\u672c\u9662\u5206\u751f\u6240\u8463\u76c8\u5c91\u535a\u58eb\u548c\u5f6d\u51a0\u667a\uff1b\u901a\u8a0a\u4f5c\u8005\u70ba\u672c\u9662\u5206\u751f\u6240\u8463\u76c8\u5c91\u535a\u58eb\u548c\u9673\u4fca\u5b89\u526f\u7814\u7a76\u54e1\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u6210\u54e1\u5305\u542b\uff1a\u9673\u5f65\u4e2d\u91ab\u5e2b\u3001\u5f35\u7dbf\u3001\u984f\u96c5\u840d\u535a\u58eb\u548c\u745e\u5178\u5361\u7f85\u7433\u5927\u5b78\u91ab\u9662\u7684Sebastian Thams\u535a\u58eb\u3002<\/p>\n

 <\/p>\n

\u8ad6\u6587\u540d\u7a31\uff1aMir-17\u223c92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration\u3002<\/strong><\/p>\n

\u8ad6\u6587\u9023\u7d50\uff1ahttps:\/www.sciencedirect.com\/science\/article\/pii\/S1934590919301651?via%3Dihub<\/a><\/strong><\/p>\n

\"\"<\/p>\n

[1]<\/a> RNA \u6709\u5169\u7a2e: \u4e00\u7a2e\u662f\u8ca0\u8cac\u88fd\u9020\u86cb\u767d\u8cea\u7684 mRNA (messenger RNA) \uff0c\u53e6\u4e00\u7a2e\u662fncRNA (non-coding RNA) \uff0c\u4e0d\u8ca0\u8cac\u88fd\u9020\u86cb\u767d\u8cea\u3002mir-17~92\u662f\u4e00\u7a2e\u5c0f\u5206\u5b50\u7684 ncRNA\uff0c\u4ea6\u5373 microRNA\uff0c\u5e6b\u5fd9\u300c\u8e29\u524e\u8eca\u300d\uff0c\u8fa8\u8a8d\u57fa\u56e0\u5e8f\u5217\u76f8\u5c0d\u61c9\u7684\u6a19\u9776 mRNA \uff0c\u4e26\u8207\u4e4b\u7d50\u5408\uff0c\u9032\u800c\u6291\u5236\u6a19\u9776 mRNA \u88fd\u9020\u86cb\u767d\u8cea\u3002\u672c\u7814\u7a76\u767c\u73fe\u7684mir-17~92\uff0c\u5176\u4e00\u4f5c\u7528\u70ba\u6291\u5236PTEN \u86cb\u767d\u8cea\u3001\u8207\u63a7\u5236PTEN\u9032\u6838\u86cb\u767d\u8cea\u7684\u91cf\u3002<\/p>\n

[2]<\/a> PTEN \u662f\u4e00\u500b\u6709\u751f\u9577\u6291\u5236\u4f5c\u7528\u7684\u6291\u764c\u57fa\u56e0\uff0c\u53ef\u4fc3\u9032\u764c\u7d30\u80de\u7684\u6b7b\u4ea1\uff1b\u672c\u6587\u5247\u7814\u7a76PTEN \u5c0d\u65bc\u795e\u7d93\u7d30\u80de\u7684\u5f71\u97ff\u3002<\/p>\n

[3]<\/a> \u6b64\u70baSOD1\u57fa\u56e0\u7f3a\u9677\u6f38\u51cd\u9f20\uff0c\u5df2\u77e5\u6709\u8a31\u591a\u57fa\u56e0\u7a81\u8b8a\u6703\u9020\u6210\u6f38\u51cd\u75c7\uff0cSOD1\u662f\u6700\u65e9\u88ab\u767c\u73fe\uff0c\u7814\u7a76\u6700\u70ba\u900f\u5fb9\u7684\u4e00\u54e1\u3002<\/p>\n

[4]<\/a> \u4e00\u822c\u4eba\u7684\u9ad4\u7d30\u80de\u5df2\u5b9a\u578b\uff0c\u4e0d\u50cf\u53d7\u7cbe\u5375\u6216\u80da\u80ce\u5e79\u7d30\u80de\u5177\u6709\u5206\u5316\u51fa\u5404\u5f0f\u7d30\u80de\u7a2e\u985e\u7684\u80fd\u529b\u3002\u8a98\u5c0e\u6027\u591a\u529f\u80fd\u5e79\u7d30\u80de(iPSC)\uff0c\u662f\u5229\u7528\u5c0e\u5165\u7279\u5b9a\u8f49\u9304\u56e0\u5b50\uff0c\u5c07\u9ad4\u7d30\u80de\u8f49\u8b8a\u6210\u985e\u4f3c\u80da\u80ce\u5e79\u7d30\u80de\u7684\u591a\u529f\u80fd\u5e79\u7d30\u80de\u3002\u904b\u7528\u9019\u500b\u65b9\u6cd5\uff0c\u53ef\u4ee5\u76f4\u63a5\u5c07\u60a3\u8005\u7684\u8840\u7403\u7d30\u80de\uff0c\u8b8a\u6210iPSC\uff0c\u518d\u5206\u5316\u6210\u904b\u52d5\u795e\u7d93\u5143(iPS~MN)\uff0c\u8b93\u79d1\u5b78\u5bb6\u4e0d\u9700\u8981\u4fb5\u5165\u6027\u5730\u5c07\u60a3\u8005\u795e\u7d93\u5143\u53d6\u51fa\u4f86\u505a\u7814\u7a76\u3002<\/p>\n

\uff08\u5206\u5b50\u751f\u7269\u7814\u7a76\u6240\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7f55\u898b\u75be\u75c5\u300c\u6f38\u51cd\u75c7\u300d\uff08\u5b78\u540d\u70ba\u808c\u840e\u7e2e\u6027\u810a\u9ad3\u5074\u7d22\u786c\u5316\u75c7\uff09\u81f3\u4eca\u9084\u6709\u8a31\u591a\u672a\u89e3\u4e4b\u8b0e\uff0c\u9664\u4e86\u7d04\u4e00\u6210\u75c5\u60a3\u70ba\u5bb6\u65cf\u907a\u50b3\uff0c\u6709\u4e5d\u6210\u60a3\u8005\u7684 […]<\/p>\n","protected":false},"author":1,"featured_media":18414,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/18315"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=18315"}],"version-history":[{"count":0,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/18315\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/18414"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=18315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=18315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=18315"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}