{"id":17956,"date":"2019-05-09T00:03:45","date_gmt":"2019-05-08T16:03:45","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=17956"},"modified":"2021-08-05T09:24:17","modified_gmt":"2021-08-05T01:24:17","slug":"%e4%b8%ad%e6%a8%9e%e7%a5%9e%e7%b6%93%e5%86%8d%e7%94%9f%e9%9c%b2%e6%9b%99%e5%85%89%e3%80%80%e4%ba%ba%e5%b7%a5%e5%90%88%e6%88%90%e5%85%ab%e9%86%a3%e9%ab%94%e5%8f%af%e4%bf%ae%e5%be%a9%e8%84%8a%e9%ab%93","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/17956\/","title":{"rendered":"\u4e2d\u6a1e\u795e\u7d93\u518d\u751f\u9732\u66d9\u5149\u3000\u4eba\u5de5\u5408\u6210\u516b\u91a3\u9ad4\u53ef\u4fee\u5fa9\u810a\u9ad3\u795e\u7d93\u5143"},"content":{"rendered":"<p>\u4e2d\u6a1e\u795e\u7d93\u53d7\u640d\u9020\u6210\u7684\u50b7\u5bb3\u5f80\u5f80\u96e3\u4ee5\u4fee\u5fa9\uff0c\u5982\u8eca\u798d\u6216\u5de5\u5bb3\u9020\u6210\u7684\u7671\u7613\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u6d2a\u4e0a\u7a0b\u4e3b\u4efb\u8207\u65e5\u672c\u540d\u53e4\u5c4b\u5927\u5b78\u91ab\u5b78\u9662\u9580\u677e\u5065\u6cbb\u9662\u9577\u7684\u6700\u65b0\u8de8\u570b\u7814\u7a76\u767c\u73fe\uff0c\u4eba\u5de5\u5408\u6210\u7684\u300c\u786b\u9178\u4e59\u91af\u809d\u7d20\uff08HS\uff09<a href=\"#_ftn1\" name=\"_ftnref1\">[1]<\/a>\u300d\u516b\u91a3\u9ad4\u53ef\u8b93\u53d7\u640d\u7684\u4e2d\u6a1e\u795e\u7d93\u5143\u6210\u529f\u555f\u52d5\u4fee\u88dc\u6a5f\u5236\u3002\u8ad6\u6587\u5df2\u65bc\u672c\uff085\uff09\u67087\u65e5\u520a\u767b\u65bc\u570b\u969b\u671f\u520a<strong>\u300a\u81ea\u7136\uff0d\u5316\u5b78\u751f\u7269\u5b78\u300b\uff08<em>Nature Chemical Biology<\/em>\uff09<\/strong>\u3002<\/p>\n<p><strong>\u4fee\u5fa9\u4e2d\u6a1e\u795e\u7d93\u7684\u95dc\u9375<\/strong><\/p>\n<p>\u4eba\u7684\u5468\u570d\u795e\u7d93\u7cfb\u7d71\uff08PNS\uff0c\u5982\u904b\u52d5\u795e\u7d93\u548c\u611f\u89ba\u795e\u7d93\uff09\u5728\u53d7\u50b7\u4e4b\u5f8c\uff0c\u901a\u5e38\u53ef\u6162\u6162\u4fee\u5fa9\u3002\u4f46\u662f\uff0c\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\uff08CNS\uff0c\u5982\u810a\u9ad3\u795e\u7d93\uff09\u7684\u4fee\u5fa9\u4ecd\u76f8\u7576\u68d8\u624b\uff0c\u4e5f\u662f\u76ee\u524d\u91ab\u5b78\u7814\u7a76\u5c1a\u5f85\u89e3\u6c7a\u7684\u554f\u984c\u3002\u7814\u7a76\u6307\u51fa\uff0c\u7576\u4e2d\u6a1e\u795e\u7d93\u53d7\u5230\u91cd\u5927\u7684\u5916\u529b\u6253\u64ca\u6642\uff0c\u4eba\u9ad4\u6703\u5206\u6ccc\u786b\u9178\u8edf\u9aa8\u7d20\uff08Chondroitin Sulfate, CS\uff09\u805a\u96c6\u65bc\u53d7\u50b7\u7684\u795e\u7d93\u8ef8\u7a81\uff08Axon\uff09\uff0c\u4e26\u548c\u53d7\u9ad4PTPR\u03c3\u7d50\u5408\uff0c\u7d93\u50ac\u5316\u4f5c\u7528\u53bb\u9664\u7d30\u80de\u8cea\u5167Cortactin\u86cb\u767d\u7684\u78f7\u9178\u6839\uff0c\u9032\u800c\u5c0e\u81f4\u795e\u7d93\u8ef8\u7a81\u672b\u7aef\u7522\u751f\u7403\u72c0\u51f8\u8d77\u7269\uff08dystrophic endballs\uff09\uff0c\u904f\u5236\u8ef8\u7a81\u7e7c\u7e8c\u751f\u9577\uff0c\u7d42\u6b62\u795e\u7d93\u4fee\u5fa9\u3002\u56e0\u6b64\uff0c\u4e2d\u6a1e\u795e\u7d93\u4fee\u5fa9\u7684\u95dc\u9375\u70ba\u6291\u5236\u53bb\u78f7\u9178\u6839\u4f5c\u7528\u3002<\/p>\n<p><strong>\u6311\u6230\u9ad8\u96e3\u5ea6\u7684\u91a3\u5206\u5b50\u5408\u6210<\/strong><\/p>\n<p>\u6d2a\u4e0a\u7a0b\u535a\u58eb\u7684\u7814\u7a76\u5718\u968a\u7e7c2011\u5e74\u6210\u529f\u5408\u62103\u865f\u6c27\u542b\u6709\u786b\u9178\u6839\u4e4bHS\u516b\u91a3\u9ad4\u80fd\u6291\u5236\u75b1\u8a3a\u4e00\u578b\u75c5\u6bd2\u611f\u67d3\u5bbf\u4e3b\u7d30\u80de\u767c\u8868\u5728\u300a\u81ea\u7136\uff0d\u5316\u5b78\u300b\uff08<em>Nature Chemistry<\/em>\uff09\u5f8c<a href=\"#_ftn2\" name=\"_ftnref2\">[2]<\/a>\uff0c\u9032\u4e00\u6b65\u767c\u73feHS\u548cCS\u7684\u5316\u5b78\u7d50\u69cb\u76f8\u8fd1\uff0c\u4e14HS\u7684\u529f\u6548\u8207\u786b\u9178\u6839\u7684\u4f4d\u7f6e\u548c\u6578\u91cf\u606f\u606f\u76f8\u95dc\u3002\u56e0\u6b64\uff0c\u70ba\u4e86\u4e00\u63a2HS\u5206\u5b50\u5982\u4f55\u8207\u53d7\u9ad4PTPR\u03c3\u4f5c\u7528\uff0c\u4ee5\u53ca\u662f\u5426\u80fd\u4fee\u5fa9\u4e2d\u6a1e\u795e\u7d93\u5143\u53d7\u640d\u7684\u8ef8\u7a81\u90e8\u4f4d\uff0c\u4ed6\u5be6\u9a57\u5ba4\u7684\u8521\u653f\u82b3\u535a\u58eb\u548c\u90ed\u5f65\u5747\u535a\u58eb\u6b77\u7d93\u591a\u5e74\u6642\u9593\uff0c\u958b\u767c\u65b0\u7684\u5408\u6210\u9014\u5f91\uff0c\u6210\u529f\u5730\u88fd\u5099\u5341\u516d\u7a2e\u4e0d\u540c\u786b\u9178\u6839\u7684HS\u516b\u91a3\u9ad4\u5206\u5b50\uff0c\u540c\u6a23\u719f\u7a14\u542b\u786b\u9178\u6839\u4e4b\u91a3\u5206\u5b50\u7814\u7a76\u7684\u65e5\u672c\u9ce5\u53d6\u5927\u5b78\u7530\u6751\u7d14\u4e00\u6559\u6388\u5e36\u9818\u7684\u5718\u968a\u5247\u8ca0\u8cac\u5408\u6210CS\u5316\u5408\u7269\u3002<\/p>\n<p><strong>\u81fa\u65e5\u5408\u4f5c<\/strong> <strong>\u6210\u679c\u6590\u7136<\/strong><\/p>\n<p>\u9580\u677e\u5065\u6cbb\u7684\u7814\u7a76\u5718\u968a\u5247\u5f9e\u8001\u9f20\u8eab\u4e0a\u53d6\u5f97\u4e00\u7a2e\u5f9e\u810a\u690e\u5ef6\u4f38\u5230\u808c\u8089\u7684\u4e2d\u6a1e\u795e\u7d93\u5143\uff0d\u80cc\u6839\u795e\u7d93\u7bc0\uff08dorsal root ganglion\uff0cDRG\uff09\uff0c\u4e26\u628a\u5207\u65b7\u7684DRG\u5206\u5225\u653e\u5230\u92ea\u4e86CS\u5316\u5408\u7269\u548cCS\u8207HS\u5316\u5408\u7269\u7684\u57f9\u990a\u76bf\u3002\u7814\u7a76\u6210\u679c\u986f\u793a\uff0c\u5be6\u9a57\u7684\u7b2c\u4e8c\u5929\u5f8c\uff0c\u8ef8\u7a81\u78b0\u5230\u57f9\u990a\u76bf\u5167\u7684CS\u6642\uff0cCS\u8207PTPR\u03c3\u7d50\u5408\uff0c\u79fb\u9664Cortactin\u86cb\u767d\u7684\u78f7\u9178\u6839\uff0c\u4fbf\u505c\u6b62\u751f\u9577\u3002\u53cd\u89c0\uff0c\u5728\u52a0\u5165\u5177\u6709\u8f03\u591a\u786b\u9178\u6839\u6578\u91cf\u4e4bHS\u516b\u91a3\u9ad4\u7684\u57f9\u990a\u76bf\u4e2d\uff0c\u8ef8\u7a81\u5247\u80fd\u6301\u7e8c\u751f\u9577\uff1b\u800c\u6c92\u6709\u786b\u9178\u6839\u6216\u786b\u9178\u6839\u6578\u91cf\u5c11\u4e4bHS\u516b\u91a3\u9ad4\u65cf\u7121\u6cd5\u8b93\u8ef8\u7a81\u7e7c\u7e8c\u751f\u9577\u3002<\/p>\n<p>\u6d2a\u4e0a\u7a0b\u535a\u58eb\u89e3\u91cb\uff0c HS\u516b\u91a3\u9ad4\u5177\u6709\u8f03\u591a\u786b\u9178\u6839\u6578\u91cf\u6642\uff0c\u80fd\u53d6\u4ee3CS\u91a3\u5206\u5b50\u4e26\u8207PTPR\u03c3\u7d50\u5408\uff0c\u4e26\u5c07\u5e7e\u500bPTPR\u03c3\u7d50\u5408\u5728\u5f62\u6210\u4f4e\u805a\u7269\uff08Oligomer\uff09\uff0c\u9032\u800c\u6291\u5236Cortactin\u86cb\u767d\u7684\u53bb\u78f7\u9178\u6839\u5316\u53cd\u61c9\uff0c\u8b93\u8ef8\u7a81\u53ef\u4ee5\u7e7c\u7e8c\u751f\u9577\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-17958\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1.jpg\" alt=\"\" width=\"777\" height=\"375\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1.jpg 960w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1-300x145.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1-768x370.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1-495x239.jpg 495w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1-960x463.jpg 990w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u540d\u53e4\u5c4b\u5927\u5b78\u91ab\u5b78\u9662\u5742\u5143\u4e00\u771f\uff08Kazuma Sakamoto\uff09\u526f\u6559\u6388\u8868\u793a\uff0c\u7814\u7a76\u767c\u73fe\u63d0\u4f9b\u4e86\u4e00\u500b\u4ee5\u5206\u5b50\u4fee\u88dc\u795e\u7d93\u5143\u7684\u5951\u6a5f\uff0cHS \u6216\u662f PTPR\u03c3\u6291\u5236\u5291\uff0c\u90fd\u53ef\u80fd\u662f\u672a\u4f86\u95dc\u9375\u7684\u7814\u767c\u76ee\u6a19\u3002<\/p>\n<p>\u7814\u7a76\u5718\u968a\u8868\u793a\uff0c\u91a3\u5206\u5b50\u7684\u5408\u6210\u5411\u4f86\u5177\u9ad8\u96e3\u5ea6\uff0c\u9019\u985e\u7d50\u69cb\u8907\u96dc\u4e4bHS\u5be1\u91a3\u5206\u5b50\u7684\u88fd\u5099\u66f4\u4e0d\u5bb9\u6613\u3002\u4f8b\u5982\u5408\u6210\u4e0d\u540c\u786b\u9178\u6839\u7684HS\u5316\u5408\u7269\uff0c\u9700\u898150\u591a\u500b\u6b65\u9a5f\uff0c\u672a\u4f86\u5c07\u671d\u7c21\u5316\u88fd\u7a0b\u3001\u63d0\u5347\u6548\u7387\u7e7c\u7e8c\u7814\u767c\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u7531\u672c\u9662\u3001\u79d1\u6280\u90e8\u3001\u4ee5\u53ca\u65e5\u672c\u6587\u90e8\u79d1\u5b78\u7701\u548c\u5b78\u8853\u632f\u8208\u6703\u5171\u540c\u8cc7\u52a9\u3002\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u70ba\u540d\u53e4\u5c4b\u5927\u5b78\u91ab\u5b78\u9662\u5742\u5143\u4e00\u771f\u548c\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u8521\u653f\u82b3\u535a\u58eb\u548c\u90ed\u5f65\u5747\u535a\u58eb\u3002\u5171\u540c\u901a\u8a0a\u4f5c\u8005\u70ba\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u6d2a\u4e0a\u7a0b\u4e3b\u4efb\u548c\u540d\u53e4\u5c4b\u5927\u5b78\u91ab\u5b78\u9662\u9580\u677e\u5065\u6cbb\u9662\u9577\uff0c\u5171\u540c\u4f5c\u8005\u5305\u62ec\u795e\u6237\u85e5\u79d1\u5927\u5b78\u526f\u6821\u9577\u5317\u5ddd\u5f18\u3001\u9ce5\u53d6\u5927\u5b78\u7530\u6751\u7d14\u4e00\u6559\u6388\u3002<\/p>\n<p>\u8ad6\u6587\u540d\u7a31\uff1a\u3008<strong>Glycan Sulfation Patterns Define Autophagy Flux at Axon Tip via PTPR\u03c3-cortactin axis<\/strong>\u3009\uff0c\u9023\u7d50\uff1a<a href=\"https:\/www.nature.com\/articles\/s41589-019-0274-x\">https:\/www.nature.com\/articles\/s41589-019-0274-x<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-18020\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1.png\" alt=\"\" width=\"836\" height=\"504\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1.png 836w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1-300x181.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1-768x463.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/05\/1-1-440x264.png 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"#_ftnref1\" name=\"_ftn1\">[1]<\/a>\u786b\u9178\u4e59\u91af\u809d\u7d20\uff08Heparan Sulfate\uff09\uff1a\u70ba\u4e00\u7dda\u5f62\u7684\u591a\u91a3\u9ad4\uff0c\u542b\u6709\u591a\u500b\u786b\u9178\u6839\uff0c\u5206\u5e03\u5728\u52d5\u7269\u7d30\u80de\u8868\u9762\u53ca\u7d30\u80de\u9593\u8cea\u4e2d\u3002\u8207\u75c5\u6bd2\u611f\u67d3\u6709\u95dc\uff0c\u76ee\u524d\u7814\u7a76\u5df2\u77e5\uff0c\u6709\u4e9b\u75c5\u6bd2\u4fb5\u5165\u7d30\u80de\u7684\u8d77\u59cb\u6b65\u9a5f\u5373\u662f\u900f\u904e\u7d30\u80de\u8868\u9762\u7684\u786b\u9178\u4e59\u91af\u809d\u7d20\u8207\u75c5\u6bd2\u9798\u819c\u86cb\u767d\u7522\u751f\u7684\u4ea4\u4e92\u4f5c\u7528\u3002<\/p>\n<p><a href=\"#_ftnref2\" name=\"_ftn2\">[2]<\/a>\u201cSynthesis of 3-<em>O<\/em>-Sulfonated Cell-Surface Heparan Sulfate Octasaccharides that Inhibit Herpes Simplex Virus Type 1 Host-Cell Interaction\u201d, <em>Nature Chemistry\u00a0<\/em>2011, <em>3<\/em>, 557\u2013563.<\/p>\n<p>\uff08\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u6a1e\u795e\u7d93\u53d7\u640d\u9020\u6210\u7684\u50b7\u5bb3\u5f80\u5f80\u96e3\u4ee5\u4fee\u5fa9\uff0c\u5982\u8eca\u798d\u6216\u5de5\u5bb3\u9020\u6210\u7684\u7671\u7613\u3002\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u6d2a\u4e0a\u7a0b\u4e3b\u4efb\u8207\u65e5\u672c\u540d\u53e4\u5c4b\u5927\u5b78\u91ab\u5b78\u9662 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":18148,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/17956"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=17956"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/17956\/revisions"}],"predecessor-version":[{"id":18019,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/17956\/revisions\/18019"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/18148"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=17956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=17956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=17956"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}