{"id":17795,"date":"2019-04-25T00:04:47","date_gmt":"2019-04-24T16:04:47","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=17795"},"modified":"2021-08-05T09:49:40","modified_gmt":"2021-08-05T01:49:40","slug":"%e5%8e%9f%e5%ad%90%e7%b4%9a%e8%a7%a3%e6%9e%90%e5%ba%a6%ef%bc%81%e6%9c%ac%e9%99%a2%e5%86%b7%e5%87%8d%e9%9b%bb%e9%a1%af%e4%b8%ad%e5%bf%83%e6%8a%8a%e5%88%86%e5%ad%90%e7%b5%90%e6%a7%8b%e7%9c%8b%e5%be%97","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/17795\/","title":{"rendered":"\u539f\u5b50\u7d1a\u89e3\u6790\u5ea6\uff01\u672c\u9662\u51b7\u51cd\u96fb\u986f\u4e2d\u5fc3\u628a\u5206\u5b50\u7d50\u69cb\u770b\u5f97\u66f4\u6e05\u695a"},"content":{"rendered":"

\u5de5\u6b32\u5584\u5176\u4e8b\uff0c\u5fc5\u5148\u5229\u5176\u5668\uff01\u672c\u9662\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u4e2d\u5fc3\u8207\u570b\u7acb\u4e2d\u592e\u5927\u5b78\u5408\u4f5c\uff0c\u904b\u7528\u51b7\u51cd\u96fb\u986f\u6280\u8853\uff0c\u4ee5\u539f\u5b50\u7d1a\u7684\u89e3\u6790\u5ea6 \u5206\u6790\u51fa\u9175\u7d20\u7684\u86cb\u767d\u8cea\u69cb\u9020\u3002\u7814\u7a76\u6210\u679c\u6709\u52a9\u65bc\u900f\u904e\u57fa\u56e0\u5de5\u7a0b\uff0c\u751f\u7522\u66f4\u591a\u751f\u8cea\u71c3\u6599\u3002\u8ad6\u6587\u5df2\u65bc4\u670817\u65e5\u520a\u8f09\u65bc\u300a\u7f8e\u570b\u5316\u5b78\u5b78\u6703\u671f\u520a\u300b\uff08Journal of the American Chemical Society<\/em>\uff09\uff0c\u671f\u520a\u4e26\u5c07\u7814\u7a76\u6210\u679c\u9078\u70ba\u7576\u671f\u5c01\u9762\uff0c\u5448\u73fe\u5982\u85dd\u8853\u5275\u4f5c\u822c\u3001\u86cb\u767d\u8cea\u9175\u7d20\u76843D\u7acb\u9ad4\u7d50\u69cb\u5716\u3002<\/p>\n

\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u8b93\u6eb6\u6db2\u4e2d\u7684\u751f\u7269\u5206\u5b50\u7d50\u69cb\u80fd\u4ee5\u9ad8\u89e3\u6790\u5ea6\u5448\u73fe\uff0c\u70ba\u79d1\u5b78\u754c\u5e36\u4f86\u4e86\u91cd\u5927\u7a81\u7834\uff0c\u65bc2017\u5e74\u7372\u5f97\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u7684\u6b8a\u69ae\u30022018\u5e74\uff0c\u672c\u9662\u8207\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u5408\u8cfc\u4e86\u4e00\u7d44\u6700\u5148\u9032\u7684\u9ad8\u89e3\u6790\u5ea6\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\uff0c\u4e26\u6210\u7acb\u300c\u4e2d\u592e\u7814\u7a76\u9662\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u4e2d\u5fc3\uff08ASCEM\uff09<\/strong>\u300d\u3002\u96a8\u5f8c\uff0c\u9ad8\u898f\u683c\u7684\u5100\u5668\u5438\u5f15\u5168\u570b\u53ca\u6d77\u5916\u7814\u7a76\u5718\u968a\u524d\u4f86\u7533\u8acb\u4f7f\u7528\u3002\u672c\u6b21\u7814\u7a76\u6210\u679c\u5373\u70ba\u570b\u7acb\u4e2d\u592e\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u9673\u9752\u8aed\u52a9\u7406\u6559\u6388\uff0c\u8207\u51b7\u51cd\u96fb\u986f\u4e2d\u5fc3\u4e3b\u6301\u4eba\u672c\u9662\u751f\u5316\u6240\u7279\u8058\u7814\u7a76\u54e1\u8521\u660e\u9053\u9662\u58eb\u5408\u4f5c\u7684\u6210\u679c\u3002<\/p>\n

\"\"

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 <\/p>\n

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\"\"

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 <\/p>\n

\u8521\u660e\u9053\u9662\u58eb\u70ba\u9175\u7d20\u5c08\u5bb6\uff0c\u65bc2012\u5e74\u7372\u9078\u70ba\u672c\u9662\u9662\u58eb\u3002\u8521\u9662\u58eb\u8868\u793a\uff1a\u300c\u4e2d\u7814\u9662\u51b7\u51cd\u96fb\u986f\u4e2d\u5fc3\u5df2\u5177\u4e16\u754c\u4e00\u6d41\u7684\u7b49\u7d1a\uff0c\u82e5\u5584\u52a0\u5229\u7528\u6b64\u8a2d\u65bd\uff0c\u5c07\u53ef\u671b\u505a\u51fa\u4e16\u754c\u4e00\u7d1a\u7684\u7814\u7a76\u3002\u672c\u6b21\u7814\u7a76\u5373\u70ba\u570b\u969b\u4e0a\u7b2c\u4e00\u7bc7\u5229\u7528\u9ad8\u89e3\u6790\u5ea6\u51b7\u51cd\u96fb\u986f\u7d50\u69cb\u4f86\u660e\u78ba\u63a2\u8a0e\u9176\u5b78\u7684\u6587\u7ae0\u3002\u300d\u4ed6\u4e5f\u63d0\u5230\uff0c\u76ee\u524d\u6709\u5c07\u8fd170\u500b\u7814\u7a76\u8a08\u756b\u6b63\u5728\u51b7\u51cd\u96fb\u986f\u4e2d\u5fc3\u904b\u4f5c\uff0c\u6210\u679c\u4e5f\u5c07\u958b\u59cb\u986f\u73fe\u3002\u672c\u7814\u7a76\u5728\u51b7\u51cd\u96fb\u986f\u5718\u968a\u5f35\u6df5\u667a\u7814\u7a76\u526f\u6280\u5e2b\u7b49\u4eba\u7684\u5354\u52a9\u4e0b\uff0c\u4e0d\u5230\u4e00\u5e74\u7684\u6642\u9593\u5373\u6709\u5091\u51fa\u6210\u679c\u3002<\/p>\n

\u6b64\u5916\uff0c\u672c\u7814\u7a76\u4e5f\u767c\u73fe\u4e86KARI\u9175\u7d20\u53ef\u80fd\u6709\u52a9\u751f\u7522\u751f\u8cea\u71c3\u6599\u7684\u95dc\u9375\u7279\u6027\u3002\u4e00\u822c\u800c\u8a00\uff0c\u9175\u7d20\u5c0d\u5e6b\u52a9\u5176\u4f5c\u7528\u7684\u8f14\u9176\u5177\u9ad8\u5ea6\u5c08\u4e00\u6027\uff0c\u6709\u5982\u540c\u300c\u4e00\u500b\u9396\u5b54\u5c0d\u4e00\u628a\u9470\u5319\u300d\u7684\u95dc\u4fc2\uff0c\u4f46\u662f\uff0cKARI\u9019\u500b\u9175\u7d20\u537b\u53ef\u4f7f\u7528\u5169\u7a2e\u8f14\u9176\uff08NADH\u8207NADPH\uff09\u3002\u900f\u904e\u51b7\u51cd\u96fb\u986f\u6280\u8853\uff0c\u672c\u7814\u7a76\u4e5f\u638c\u63e1\u4e86\u5176\u300c\u4e00\u500b\u9396\u5b54\u9069\u7528\u4e0d\u540c\u9470\u5319\u300d\u4e4b\u9580\u8def\uff0c\u4e5f\u5c31\u662fKARI\u9175\u7d20\u5c0d\u8f14\u9176\u7684\u96d9\u91cd\u7279\u7570\u6027\u3002\u9019\u9664\u4e86\u662f\u672c\u7814\u7a76\u7684\u7368\u9053\u4e4b\u8655\uff0c\u4e5f\u8b93\u57fa\u56e0\u5de5\u7a0b\u5b78\u5bb6\u53ef\u85c9\u6b64\u7e7c\u7e8c\u63a2\u7d22\u65bc\u5de5\u696d\u61c9\u7528KARI\u9175\u7d20\u7684\u53ef\u80fd\u6027\u3002<\/p>\n

\u8fd1\u5e74\u4f86\uff0c\u672c\u9662\u5ed6\u4fca\u667a\u9662\u9577\u4ee5\u53ca2018\u5e74\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u5f97\u4e3b\u5f17\u6717\u897f\u7d72\u2022\u963f\u8afe\u5fb7\uff08Frances Hamilton Arnold\uff09\u535a\u58eb\u5229\u7528\u5fae\u751f\u7269\u57fa\u56e0\u5de5\u7a0b\uff0c\u4fee\u6539\u5927\u8178\u687f\u83cc\u652f\u93c8\u578b\u80fa\u57fa\u9178\u7684\u751f\u7269\u5408\u6210\u9014\u5f91\uff0c\u4f86\u751f\u7522\u751f\u8cea\u71c3\u6599\u2500\u2500\u7570\u4e01\u9187\u3002\u800c\u56e0\u70baNADH\u7684\u6210\u672c\u8f03NADPH\u4f4e\uff0c\u963f\u8afe\u5fb7\u9577\u671f\u4ee5\u4f86\u7814\u7a76\u5982\u4f55\u8b93KARI\u9175\u7d20\u5c0dNAPDH\u7684\u504f\u597d\u6539\u6210NADH\uff0c\u4ee5\u751f\u7522\u66f4\u591a\u7570\u4e01\u9187\u3002\u56e0\u6b64\uff0c\u6b64\u6b21\u672c\u9662\u53ca\u4e2d\u592e\u5927\u5b78\u5718\u968a\u5c0d\u6b64\u9175\u7d20\u7279\u6027\u7684\u638c\u63e1\uff0c\u5c07\u6709\u9ad8\u5ea6\u7684\u5de5\u696d\u61c9\u7528\u50f9\u503c\u3002<\/p>\n

\u9673\u9752\u8aed\u4e5f\u4e0d\u8af1\u8a00\uff0c\u6b64\u6b21\u7814\u7a76\u7684\u4eae\u9ede\u4e4b\u4e00\uff0c\u662f\u5979\u842c\u5ff5\u4ff1\u7070\u4e0b\u7684\u9748\u5149\u4e4d\u73fe\u3002\u7576\u6642\u9175\u7d20\u7d50\u69cb\u7684\u89e3\u6790\u5ea6\u6709\u505a\u51fa\u4f86\uff0c\u4f46\u537b\u4e00\u9ede\u6d3b\u6027\u4e5f\u6c92\u6709\uff0c\u9762\u81e8\u53ef\u80fd\u5931\u6557\u91cd\u4f86\u7684\u6cae\u55aa\uff0c\u8b93\u5979\u6574\u6574\u82e6\u60f1\u4e86\u4e00\u500b\u591a\u6708\u3002\u505c\u4e0b\u8173\u6b65\u91cd\u65b0\u601d\u8003\u5f8c\uff0c\u5979\u610f\u5916\u638c\u63e1\u5230\u9178\u9e7c\u503c\u9019\u9805\u95dc\u9375\u56e0\u7d20\uff0c\u540c\u6642\u4e5f\u5229\u7528\u51b7\u51cd\u96fb\u986f\u7d50\u69cb\u63ed\u793a\u4e86\u9019\u500b\u9175\u7d20\u7684\u6d3b\u6027\u5982\u4f55\u53d7\u5230\u9178\u9e7c\u503c\u7684\u5f71\u97ff\u3002<\/p>\n

\u9673\u9752\u8aed\u904e\u53bb\u5728\u672c\u9662\u738b\u60e0\u921e\u9662\u58eb\u53ca\u9673\u9577\u8b19\u9662\u58eb\u5171\u540c\u6307\u5c0e\u4e0b\uff0c\u65bc\u672c\u9662\u5316\u5b78\u6240\u958b\u59cb\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u6280\u8853\u7684\u7814\u7a76\u4e4b\u8def\u3002\u5979\u8868\u793a\uff1a\u300c\u73fe\u4eca\u9ad8\u89e3\u6790\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u5982\u864e\u6dfb\u7ffc\uff0c\u5229\u7528\u96fb\u986f\u5c0d\u86cb\u767d\u8cea\u5206\u5b50\u62cd\u7167\uff0c\u53ef\u53d6\u5f97\u6210\u5343\u4e0a\u842c\u500b\u4e0d\u540c\u9762\u5411\u7684\u500b\u5225\u86cb\u767d\u8cea\u5206\u5b50\u5f71\u50cf\uff0c\u4ee5\u6578\u5b78\u65b9\u6cd5\u4f86\u91cd\u69cb\uff0c\u53ef\u9054\u8fd1\u4f3c\u539f\u5b50\u7b49\u7d1a\u7684\u89e3\u6790\u5ea6\uff0c\u5c07\u86cb\u767d\u8cea\u7d50\u69cb\u770b\u5f97\u4e00\u6e05\u4e8c\u695a\uff0c\u4e5f\u662f\u4e00\u5927\u7a81\u7834\uff01\u300d<\/p>\n

\"\"

\u5716\u8aaa\uff1a\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u4e0b\u7684\u86cb\u767d\u8cea\u5f71\u50cf\u3002<\/p><\/div>\n

 <\/p>\n

\u6b64\u7bc7\u7814\u7a76\u4e0d\u50c5\u662f\u773e\u591a\u7814\u7a76\u4eba\u54e1\u7684\u6210\u679c\uff0c\u4e5f\u662f\u672c\u9662\u51b7\u51cd\u96fb\u986f\u4e2d\u5fc3\u7684\u4f5c\u54c1\uff0c\u5c0d\u9577\u671f\u7d66\u4e88\u51b7\u51cd\u96fb\u986f\u7814\u7a76\u7d93\u8cbb\u652f\u6301\u7684\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u6709\u83ab\u5927\u9f13\u821e\uff0c\u800c\u9664\u4e86\u51b7\u51cd\u96fb\u986f\u5718\u968a\uff0c\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u4e5f\u5927\u529b\u6276\u690d\u8207\u764c\u75c7\u6216\u91cd\u5927\u75be\u75c5\u91ab\u7642\u6aa2\u6e2c\u76f8\u95dc\u4e4b\u86cb\u767d\u8cea\u7d50\u69cb\u5206\u6790\u3001\u6297\u9ad4\u53ca\u85e5\u7269\u958b\u767c\u7b49\u591a\u500b\u7814\u7a76\u5718\u968a\u3002<\/p>\n

\u672c\u7814\u7a76\u8ad6\u6587\u6a19\u984c\u70ba\uff1a”Use of Cryo-EM to Uncover Structural Bases of pH Effect and Cofactor Bi-specificity of Ketol-acid Reductoisomerase<\/strong>”<\/p>\n

\u8ad6\u6587\u5168\u6587\uff1a https:\/pubs.acs.org\/doi\/10.1021\/jacs.9b01354<\/a><\/p>\n

\u4e2d\u592e\u7814\u7a76\u9662\u51b7\u51cd\u96fb\u986f\u4e2d\u5fc3\uff08ASCEM\uff09\uff1ahttp:\/cryoem.ibc.sinica.edu.tw<\/a><\/p>\n

\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\uff08TPP\uff09\u5b98\u7db2\uff1ahttp:\/tpp.sinica.edu.tw<\/a><\/p>\n

 <\/p>\n

\"\"

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 <\/p>\n

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