{"id":17792,"date":"2019-04-25T08:00:54","date_gmt":"2019-04-25T00:00:54","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=17792"},"modified":"2021-08-05T09:34:58","modified_gmt":"2021-08-05T01:34:58","slug":"%e5%b0%8d%e4%bb%98%e6%b0%a3%e5%96%98%e7%9a%84%e6%96%b0%e7%ad%96%e7%95%a5%ef%bc%81-%e4%bb%a5%e3%80%8c%e5%85%8d%e7%96%ab%e8%aa%bf%e6%8e%a7%e5%be%ae%e7%b2%92%e5%ad%90%e3%80%8d%e6%b2%bb%e7%99%82%e9%a1%9e","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/17792\/","title":{"rendered":"\u5c0d\u4ed8\u6c23\u5598\u7684\u65b0\u7b56\u7565\uff01 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\uff08microparticle\uff09\u4ee5\u5438\u5165\u5291\u578b\u6295\u85e5\uff0c\u767c\u73fe\u6709\u52a9\u65bc\u6cbb\u7642\u6c23\u5598\u3002\u7814\u7a76\u6210\u679c\u5df2\u65bc\u4eca\uff08108\uff09\u5e743\u6708\u520a\u767b\u65bc\u300a\u904e\u654f\u548c\u81e8\u5e8a\u514d\u75ab\u5b78\u96dc\u8a8c\u300b<em>\uff08Journal of Allergy and Clinical Immunology\uff09<\/em>\u3002<\/p>\n<p>&nbsp;<\/p>\n<div id=\"attachment_17793\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-17793\" class=\"wp-image-17793 size-large\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-1024x617.png\" alt=\"\" width=\"1024\" height=\"617\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-1024x617.png 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-300x181.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-768x463.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-1080x651.png 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-440x264.png 440w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-840x506.png 840w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-17793\" class=\"wp-caption-text\">\u25b2\u514d\u75ab\u8abf\u63a7\u793a\u610f\u5716<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u5f35\u96c5\u8c9e\u8868\u793a\uff0c\u300c\u904e\u53bb\u8a8d\u70baT\u7d30\u80de\u624d\u662f\u9020\u6210\u6c23\u5598\u7684\u4e3b\u56e0\uff08\u8a3b1\uff09 \uff0c\u4e26\u4ee5\u985e\u56fa\u9187\u5438\u5165\u5291\u6cbb\u7642\uff1b\u96a8\u8457\u6108\u4f86\u6108\u591a\u985e\u56fa\u9187\u6297\u85e5\u6027\u60a3\u8005\u589e\u52a0\uff0c\u672c\u7814\u7a76\u767c\u73fe\u7684 ILC2\u7d30\u80de\u88ab\u8996\u70ba\u65b0\u7684\u6c23\u5598\u6cbb\u7642\u6a19\u7684\u300d\u3002\u6c23\u5598\u75be\u75c5\u662f\u4e00\u7a2e\u514d\u75ab\u5931\u8861\uff0cILC2\u7d30\u80de\u4f5c\u7528\u65bc\u514d\u75ab\u7cfb\u7d71\u4e2d\uff0c\u6703\u88ab\u5875\u8e63\u3001\u9ef4\u83cc\u8a98\u767c\u6d3b\u5316\uff0c\u50b3\u905e\u6c23\u5598\u767c\u708e\u53cd\u61c9\u8a0a\u606f\uff0c\u9020\u6210\u6c23\u7ba1\u6536\u7e2e\u3001\u9ecf\u6db2\u5206\u6ccc\u4ea2\u9032\u7b49\u75c7\u72c0\u3002<\/p>\n<p>\u672c\u7814\u7a76\u4ee5\u514d\u75ab\u8abf\u63a7\u6cbb\u7642\u6c23\u5598\uff0c\u4f7f\u7528\u5e36\u6709\u300cTLR9\u914d\u9ad4\uff08CpG\uff09\u300d\u7684\u514d\u75ab\u8abf\u63a7\u5fae\u7c92\u5b50\uff0c\u53ef\u5206\u6ccc\u5e72\u64fe\u7d20\u4ee5\u6291\u5236ILC2\u7d30\u80de\u50b3\u905e\u6c23\u5598\u767c\u708e\u53cd\u61c9\u8a0a\u606f\u3002\u4ee5\u514d\u75ab\u8abf\u63a7\u6cbb\u7642\u6c23\u5598\u7684\u904b\u4f5c\u539f\u7406\u70ba\uff1a\u900f\u904e\u985e\u9438\u53d7\u9ad4\uff08TLR9\uff09\u8207\u914d\u9ad4\uff08CpG\uff09\u7d50\u5408\u5f8c\uff08\u8a3b2\uff09 \uff0c\u523a\u6fc0\u300c\u6f3f\u7d30\u80de\u6a23\u6a39\u7a81\u72c0\u7d30\u80de\u300d\uff08plasmacytoid dendritic cell, pDC\uff09\u5206\u6ccc\u03b1\u578b\u5e72\u64fe\u7d20 \uff08IFN-\u03b1\uff09\uff1b\u9032\u800c\u6d3b\u5316\u300c\u81ea\u7136\u6bba\u624b\u7d30\u80de\u300d\uff08NK cell\uff09\u589e\u52a0\u03b3\u578b\u5e72\u64fe\u7d20\uff08IFN-\u03b3\uff09\u5206\u6ccc\u91cf\uff0c\u9054\u5230\u6291\u5236ILC2\u7d30\u80de\u589e\u751f\u7684\u6548\u679c\u3002\uff08\u8a73\u898b\u4e0b\u65b9\u793a\u610f\u5716\uff09<\/p>\n<div id=\"attachment_17794\" style=\"width: 681px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-17794\" class=\"wp-image-17794 size-full\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-2-1.jpg\" alt=\"\" width=\"671\" height=\"394\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-2-1.jpg 671w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-1-2-1-300x176.jpg 300w\" sizes=\"(max-width: 671px) 100vw, 671px\" \/><p id=\"caption-attachment-17794\" class=\"wp-caption-text\">\u25b2\u5716\u8aaa\uff1a \uff08A\uff09 \u6c23\u5598\u767c\u708e\u53cd\u61c9\u4e0a\u6e38\uff1a\u7576\u985e\u9438\u53d7\u9ad49 \uff08TLR9\uff09 \u53d7\u5230\u5176\u914d\u9ad4 \uff08ligand\uff09 CpG\u523a\u6fc0\u5f8c\uff0c\u6d3b\u5316\u81ea\u7136\u6bba\u624b\u7d30\u80de\u5206\u6ccc\u5e72\u64fe\u7d20\uff08IFN-\u03b3\uff09\uff0c\u53ef\u6291\u5236ILC2\u7d30\u80de\u589e\u751f\u3002 \uff08B\uff09 \u6c23\u5598\u767c\u708e\u53cd\u61c9\u4e0b\u6e38\uff1aILC2\u7d30\u80de\u9020\u6210\u7684\u6c23\u5598\u75c7\u72c0<\/p><\/div>\n<p>&nbsp;<\/p>\n<p>\u514d\u75ab\u8abf\u63a7\u5fae\u7c92\u5b50\uff08MIS416\uff09\u542b\u6709\u80fd\u523a\u6fc0\u5206\u6ccc\u5e72\u64fe\u7d20\u7684TLR9\u914d\u9ad4\uff08CpG\uff09\u6210\u5206\uff0c\u7814\u7a76\u5718\u968a\u4ee5\u5438\u5165\u5291\u578b\u6295\u85e5\u9032\u884c\u8001\u9f20\u5be6\u9a57\uff0c\u671f\u671b\u5728\u4fb5\u5165\u6027\u6700\u5c0f\u7684\u60c5\u6cc1\u4e0b\u5c07\u85e5\u7269\u9001\u5165\u80ba\u90e8\uff0c\u767c\u73fe\u53ef\u6291\u5236ILC2\u7d30\u80de\u6240\u5c0e\u81f4\u7684\u6c23\u5598\u75c7\u72c0\uff1b\u5c0d\u65bcT\u7d30\u80de\u5c0e\u81f4\u7684\u6c23\u5598\u75c7\u72c0\u4e5f\u6709\u7642\u6548\uff0c\u76f8\u8f03\u65bc\u76ee\u524d\u7684\u985e\u56fa\u9187\u8655\u65b9\u85e5\u66f4\u5177\u512a\u52e2\u3002<\/p>\n<p>\u5f35\u96c5\u8c9e\u52a9\u7814\u7a76\u54e1\u8868\u793a\uff0c\u5fae\u7c92\u5b50\uff08MIS416\uff09\u6e90\u81ea\u75e4\u7621\u4e19\u9178\u687f\u83cc \uff08Propionibacterium acnes\uff09\uff0c\u4e5f\u5c31\u662f\u5927\u5bb6\u719f\u6089\u7684\u9752\u6625\u75d8\u83cc\uff0c\u542b\u6709CpG\u6210\u5206\uff0c\u4e14\u5177\u6709\u751f\u7269\u53ef\u5206\u89e3\u6027\uff0c\u5c0d\u65bc\u4eba\u9ad4\u76f8\u7576\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u7531\u672c\u9662\u53ca\u79d1\u6280\u90e8\u652f\u6301\uff0c\u7814\u7a76\u5718\u968a\u6210\u54e1\u5305\u62ec\uff1a\u672c\u9662\u751f\u91ab\u6240\u5f35\u96c5\u8c9e\u52a9\u7814\u7a76\u54e1\u3001\u7b2c\u4e00\u4f5c\u8005\u5f35\u9e97\u840d\u535a\u58eb\uff0c\u4e26\u7d10\u897f\u862d\u751f\u6280\u516c\u53f8\u7684Gill Webster\u535a\u58eb\u5408\u4f5c\u3002\u671f\u520a\u6587\u7ae0\u6a19\u984c\u70ba\u300cTLR9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity\u300d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u8ad6\u6587\u9023\u7d50\uff1a <a href=\"https:\/doi.org\/10.1016\/j.jaci.2019.03.008\">https:\/doi.org\/10.1016\/j.jaci.2019.03.008<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>\u8a3b1\uff1a\u904e\u5f80\u7814\u7a76\u5206\u6790\uff0c\u7531T\u7d30\u80de\u8a98\u767c\u7684\u6c23\u5598\u53cd\u61c9\uff0c\u5177\u6709\u7279\u5b9a\u904e\u654f\u539f\uff0c\u900f\u904e\u6291\u5236T\u7d30\u80de\u6d3b\u5316\u589e\u751f\u7684\u65b9\u5f0f\uff0c\u4ee5\u985e\u56fa\u9187\u5438\u5165\u5291\u6cbb\u7642\u3002<\/p>\n<p>\u8a3b2\uff1a\u914d\u9ad4\u8207\u53d7\u9ad4\u7684\u7d50\u5408\u662f\u4e00\u7a2e\u5206\u5b50\u8b58\u5225\u904e\u7a0b\u3002\u53d7\u9ad4(receptor)\u662f\u7d30\u80de\u819c\u4e0a\u7684\u7279\u6b8a\u86cb\u767d\u5206\u5b50\uff0c\u53ef\u8b58\u5225\u548c\u9078\u64c7\u6027\u5730\u8207\u67d0\u4e9b\u7269\u8cea\u767c\u751f\u7279\u7570\u6027\u53d7\u9ad4\u7d50\u5408\u53cd\u61c9\uff0c\u7522\u751f\u76f8\u61c9\u7684\u751f\u7269\u6548\u61c9\uff1b\u914d\u9ad4(ligand)\u662f\u6307\u4e00\u4e9b\u4fe1\u865f\u7269\u8cea\uff0c\u9664\u4e86\u8207\u53d7\u9ad4\u7d50\u5408\u5916\u672c\u8eab\u4e26\u7121\u5176\u4ed6\u529f\u80fd\u3002\u672c\u6587\u6240\u6307\u7684\u985e\u9438\u53d7\u9ad49 (TLR9) \u53d7\u5230\u5176\u914d\u9ad4 (ligand) CpG\u523a\u6fc0\u5f8c\u6703\u7d50\u5408\u3002\u5e36\u6709\u300cTLR9 \u914d\u9ad4(CpG)\u300d\u662f\u672c\u7814\u7a76\u767c\u73fe\u6c23\u5598\u514d\u75ab\u8abf\u63a7\u88e1\u7684\u91cd\u8981\u4fe1\u865f\u3002<\/p>\n<p>\uff08\u751f\u91ab\u6240\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6cbb\u7642\u6c23\u5598\u4e3b\u8981\u4f7f\u7528\u6297\u767c\u708e\u85e5\uff0d\u985e\u56fa\u9187\uff0c\u4f46\u8fd1\u5e74\u4f86\u6108\u4f86\u6108\u591a\u60a3\u8005\u51fa\u73fe\u985e\u56fa\u9187\u6297\u85e5\u6027\u53cd\u61c9\uff0c\u6df1\u53d7\u6c23\u5598\u6240\u82e6\u3002\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":17793,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/17792"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=17792"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/17792\/revisions"}],"predecessor-version":[{"id":17824,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/17792\/revisions\/17824"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/17793"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=17792"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=17792"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=17792"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}