{"id":16919,"date":"2019-04-11T00:03:49","date_gmt":"2019-04-10T16:03:49","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=16919"},"modified":"2021-08-05T15:07:15","modified_gmt":"2021-08-05T07:07:15","slug":"%e5%87%8d%e7%b5%90%e7%b4%b0%e8%83%9e%e7%9a%84%e9%9d%92%e6%98%a5-%e3%80%8c%e6%9e%9c%e5%87%8d%e7%b4%b0%e8%83%9e%e3%80%8d%e5%8a%a9%e7%97%85%e6%af%92%e6%aa%a2%e6%b8%ac%e3%80%81%e5%85%8d%e7%96%ab%e6%b2%bb","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/16919\/","title":{"rendered":"\u51cd\u7d50\u7d30\u80de\u7684\u9752\u6625 \u300c\u679c\u51cd\u7d30\u80de\u300d\u52a9\u75c5\u6bd2\u6aa2\u6e2c\u3001\u514d\u75ab\u6cbb\u7642"},"content":{"rendered":"<p>\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240<a href=\"http:\/www.ibms.sinica.edu.tw\/jackhu\/\"><strong>\u80e1\u54f2\u9298<\/strong>\u52a9\u7814\u7a76\u54e1<\/a>\u8207\u7814\u7a76\u5718\u968a\u7684\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0c\u5728\u7d30\u80de\u4e2d\u6ce8\u5165\u72c0\u4f3c\u679c\u51cd\u7684\u6c34\u51dd\u81a0\uff08PEG\uff09\u5f8c\u8b8a\u6210\u300c\u679c\u51cd\u7d30\u80de\u300d\uff0c\u53ef\u4ee5\u5728\u7d30\u80de\u6b7b\u4ea1\u6642\u4fdd\u5b58\u7d30\u80de\u819c\u4e0a\u86cb\u767d\u8cea\u3001\u91a3\u985e\u7b49\u751f\u7269\u6d3b\u6027\u3002\u6709\u52a9\u65bc\u5e79\u7d30\u80de\u7814\u7a76\u3001\u514d\u75ab\u6cbb\u7642\u4ee5\u53ca\u75c5\u6bd2\u6aa2\u6e2c\u6280\u8853\u7814\u767c\u3002\u7814\u7a76\u6210\u679c\u65bc\u4eca(108)\u5e743\u67085\u65e5\u520a\u767b\u65bc<strong>\u300a\u81ea\u7136\u901a\u8a0a\u300b\uff08<em>Nature Communications<\/em>\uff09<\/strong>\u671f\u520a\u4e0a\uff0c\u4e26\u5df2\u7533\u8acb\u591a\u570b\u5c08\u5229\u3002<\/p>\n<div id=\"attachment_16923\" style=\"width: 846px\" class=\"wp-caption 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class=\"wp-caption-text\">\u672c\u9662\u751f\u91ab\u6240\u80e1\u54f2\u9298\u52a9\u7814\u7a76\u54e1<\/p><\/div>\n<p>\u4e00\u822c\u800c\u8a00\uff0c\u7d30\u80de\u819c\u7684\u754c\u9762\u8907\u96dc\u4e14\u8106\u5f31\uff0c\u7576\u7d30\u80de\u6b7b\u4ea1\u5f8c\uff0c\u7d30\u80de\u9aa8\u67b6\u7db2\u7d61\u7684\u5206\u89e3\u6703\u7834\u58de\u7d30\u80de\u8cea\u8207\u7d30\u80de\u819c\u4e2d\u7684\u652f\u6490\uff0c\u9032\u800c\u5c0e\u81f4\u819c\u7834\u88c2\u548c\u5d29\u89e3\u3002\u904e\u5f80\u8a31\u591a\u7814\u7a76\u82e5\u8981\u4fdd\u7559\u7d30\u80de\u7269\u8cea\u6d3b\u6027\u5f97\u7d93\u904e\u7e41\u7463\u7684\u6b65\u9a5f\uff0c\u800c\u4e14\u4e5f\u4e0d\u76e1\u7136\u80fd\u5b8c\u6574\u4fdd\u5b58\u3002\u80e1\u54f2\u9298\u8868\u793a\uff1a\u300c\u6b64\u7814\u7a76\u7a81\u7834\u4e86\u7d30\u80de\u9aa8\u67b6\u7db2\u7d61\u6703\u88ab\u5206\u89e3\u8207\u7834\u58de\u7684\u5148\u5929\u9650\u5236\u300d\u3002<\/p>\n<p>\u80e1\u54f2\u9298\u7814\u7a76\u5718\u968a\u958b\u767c\u51fa\u4e00\u7a2e\u65b0\u6280\u8853\uff0c\u900f\u904e\u6c34\u51dd\u81a0\u5316\u7d30\u80de\u4f86\u4fdd\u6301\u7d30\u80de\u819c\u7684\u6d41\u52d5\u6027\u8207\u7d30\u80de\u819c\u4ecb\u9762\u6d3b\u6027\uff0c\u85c9\u6b64\u4fdd\u5b58\u7d30\u80de\u819c\u7684\u751f\u7269\u7279\u6027\u9577\u905430\u5929\u4ee5\u4e0a\uff0c\u6d3b\u6027\u4e0d\u6e1b\u4e14\u5177\u9ad8\u5ea6\u7a69\u5b9a\u6027\u3002\u80e1\u54f2\u9298\u8868\u793a\uff0c\u56e0\u6c34\u51dd\u81a0\u7d30\u80de\u8cea\u5730\u985e\u4f3c\u679c\u51cd\uff0c\u4e5f\u53ef\u7a31\u70ba\u300c\u679c\u51cd\u7d30\u80de\u300d\uff0c\u4e0d\u50c5\u80fd\u4fdd\u6301\u7d30\u80de\u819c\u8102\u985e\u7684\u6392\u5217\u9806\u5e8f\u548c\u7d30\u80de\u819c\u86cb\u767d\u8cea\u79fb\u52d5\u6027\uff0c\u4e5f\u80fd\u7dad\u6301\u7d30\u80de\u8868\u9762\u53d7\u9ad4\u8207\u75c5\u6bd2\u6297\u539f\u4e4b\u4ea4\u4e92\u4f5c\u7528\u3002<\/p>\n<p>\u5be6\u9a57\u4ee5\u6297\u539f\u5448\u73fe\u7d30\u80de\uff08antigen-presenting cells, APC\uff09\uff08\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7121\u6cd5\u76f4\u63a5\u8fa8\u8b58\u5916\u4f86\u6297\u539f\uff0f\u75c5\u539f\u9ad4\uff0c\u5fc5\u9808\u4f9d\u9760\u9ad4\u5167\u7684\u6297\u539f\u5448\u73fe\u7d30\u80de\u5982\u5de8\u566c\u7d30\u80de\u3001\u6a39\u7a81\u72c0\u7d30\u80de\u3001B\u7d30\u80de\u7b49\u5c07\u6297\u539f\u7684\u4e00\u90e8\u5206\u9644\u8457\u5728\u7d30\u80de\u8868\u9762\uff0c\u4f9bT\u7d30\u80de\u8fa8\u8b58\u6297\u539f\uff0c\u9032\u884c\u5c08\u4e00\u6027\u514d\u75ab\u53cd\u61c9\uff0f\u5f8c\u5929\u514d\u75ab\u53cd\u61c9\uff09\u70ba\u7814\u7a76\u6a19\u7684\uff0c\u7814\u7a76\u5718\u968a\u5c07\u6c34\u51dd\u81a0\u6ce8\u5165\u6297\u539f\u5448\u73fe\u7d30\u80de\uff0c\u518d\u8207T\u6dcb\u5df4\u7d30\u80de\u7d50\u5408\u3002\u5be6\u9a57\u7d50\u679c\u986f\u793a\uff0c\u6210\u70ba\u679c\u51cd\u7d30\u80de\u7684\u6297\u539f\u5448\u73fe\u7d30\u80de\uff0c\u80fd\u6709\u6548\u4fc3\u9032T\u6dcb\u5df4\u7d30\u80de\u7684\u589e\u751f\uff0c\u6709\u52a9\u514d\u75ab\u6cbb\u7642\u548c\u75c5\u6bd2\u6aa2\u6e2c\u7684\u7814\u767c\u3002<\/p>\n<p>\u679c\u51cd\u7d30\u80de\u7684\u751f\u7522\u904e\u7a0b\u76f8\u5c0d\u7c21\u6613\uff0c\u7814\u7a76\u5718\u968a\u5148\u5c07\u6d3b\u7d30\u80de\u51b7\u51cd\u4e26\u89e3\u51cd\uff0c\u4f7f\u7d30\u80de\u8868\u9762\u66ab\u6642\u7522\u751f\u7d30\u5c0f\u7a7f\u5b54\uff0c\u4e4b\u5f8c\u5c07\u6d3b\u7d30\u80de\u6d78\u6ce1\u65bc\u6c34\u51dd\u81a0\u88fd\u5291\u4e2d\uff0c\u8b93\u7247\u6bb5\u6c34\u81a0\u53ef\u4ee5\u6ef2\u5165\u7d30\u80de\u3002\u63a5\u8457\u7167\u5c04UV\u71c8\uff0c\u9032\u884c\u5149\u6d3b\u5316\u4e4b\u5316\u5b78\u53cd\u61c9\uff0c\u4f7f\u5176\u7247\u6bb5\u5408\u6210\u6c34\u51dd\u81a0\u805a\u5408\u7269\uff0c\u53d6\u4ee3\u81ea\u7136\u7684\u7d30\u80de\u9aa8\u67b6\u7db2\u7d61\uff0c\u7dad\u6301\u539f\u672c\u7d30\u80de\u5916\u578b\u3002\u80e1\u54f2\u9298\u8868\u793a\uff0c\u7d30\u80de\u5167\u6ce8\u5165\u6c34\u51dd\u81a0\u662f\u7a81\u7834\u6027\u7684\u65b0\u6280\u8853\uff0c\u901a\u7528\u65bc\u751f\u7269\u819c\u7814\u7a76\u548c\u751f\u7269\u91ab\u5b78\u4e0a\u69cb\u5efa\u4eba\u5de5\u7d30\u80de\u7684\u7d30\u80de\u56fa\u5b9a\u65b9\u6cd5\uff0c\u5c07\u4f86\u53ef\u671b\u61c9\u7528\u65bc\u5404\u7a2e\u7d30\u80de\u819c\u6240\u7522\u751f\u4e4b\u4ea4\u4e92\u4f5c\u7528\u5f15\u767c\u7684\u751f\u7269\u529f\u80fd\u8abf\u63a7\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u7531\u300c\u4e2d\u7814\u9662\u524d\u77bb\u8a08\u756b\u300d\u652f\u6301\uff0c\u5171\u540c\u7b2c\u4e00\u4f5c\u8005\u70ba\u80e1\u54f2\u9298\u5be6\u9a57\u5ba4\u6210\u54e1\u6797\u69ae\u8fb0\u3001\u7c21\u798e\u7469\u3001\u6797\u5fd7\u9686\uff0c\u901a\u8a0a\u4f5c\u8005\u70ba\u80e1\u54f2\u9298\u3002\u7814\u7a76\u5718\u968a\u6210\u54e1\u5305\u62ec\u59da\u79c9\u745c\u3001\u9673\u5a49\u5b9c\u3001\u5289\u7389\u6db5\u3001\u9673\u777f\u6021\u3001\u9673\u8587\u96c5\uff0c\u8207\u81fa\u7063\u5927\u5b78\u7378\u91ab\u5b78\u7cfb\u526f\u6559\u6388\u9673\u6167\u6587\u53ca\u81fa\u5927\u7378\u91ab\u7cfb\u5b78\u751f\u65b9\u7d2b\u73e3\u3001\u674e\u8afe\u8afe\u3002<\/p>\n<p>\u6587\u7ae0\u6a19\u984c\u70ba\u300c<strong>Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions<\/strong>\u300d\u3002<\/p>\n<p>\u8ad6\u6587\u9023\u7d50\uff1a <a href=\"https:\/www.nature.com\/articles\/s41467-019-09049-5\">https:\/www.nature.com\/articles\/s41467-019-09049-5<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-16922\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-2-1.png\" alt=\"\" width=\"1453\" height=\"898\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-2-1.png 1453w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-2-1-300x185.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-2-1-768x475.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-2-1-1024x633.png 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-2-1-1080x667.png 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2019\/04\/1-2-1-574x355.png 574w\" sizes=\"(max-width: 1453px) 100vw, 1453px\" \/><\/p>\n<p>\uff08\u5716\u3001\u6587\uff0f\u751f\u91ab\u6240\uff1b\u7167\u7247\uff0f\u8cc7\u8a0a\u8655\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u80e1\u54f2\u9298\u52a9\u7814\u7a76\u54e1\u8207\u7814\u7a76\u5718\u968a\u7684\u6700\u65b0\u7814\u7a76\u767c\u73fe\uff0c\u5728\u7d30\u80de\u4e2d\u6ce8\u5165\u72c0\u4f3c\u679c\u51cd\u7684\u6c34\u51dd\u81a0\uff08PEG\uff09\u5f8c\u8b8a\u6210\u300c\u679c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":16923,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/16919"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=16919"}],"version-history":[{"count":2,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/16919\/revisions"}],"predecessor-version":[{"id":25132,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/16919\/revisions\/25132"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/16923"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=16919"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=16919"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=16919"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}