{"id":16137,"date":"2019-01-17T00:05:43","date_gmt":"2019-01-16T16:05:43","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=16137"},"modified":"2020-12-30T13:57:29","modified_gmt":"2020-12-30T05:57:29","slug":"%e8%85%a6%e7%99%8c%e6%82%a3%e8%80%85%e7%a6%8f%e9%9f%b3%ef%bc%81%e7%aa%81%e7%a0%b4%e9%98%b2%e8%ad%b7%e7%bd%a9-%e6%88%90%e5%8a%9f%e8%bc%b8%e9%80%81%e5%a5%88%e7%b1%b3%e8%97%a5%e7%89%a9-%e9%96%8b%e5%95%9f","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/16137\/","title":{"rendered":"\u8166\u764c\u60a3\u8005\u798f\u97f3\uff01\u7a81\u7834\u9632\u8b77\u7f69 \u6210\u529f\u8f38\u9001\u5948\u7c73\u85e5\u7269 \u958b\u555f\u8166\u764c\u6cbb\u7642\u4e4b\u9470"},"content":{"rendered":"

\u8840\u8166\u969c\u58c1\uff08blood brain barrier\uff09\u662f\u8166\u7624\u6cbb\u7642\u7684\u4e3b\u8981\u969c\u7919\uff0c\u5316\u7642\u85e5\u7269\u88ab\u963b\u9694\u5728\u5916\uff0c\u7121\u6cd5\u6709\u6548\u6bba\u6b7b\u764c\u7d30\u80de\u3002\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u8b1d\u6e05\u6cb3\u7814\u7a76\u54e1\u5718\u968a\u767c\u73fe\uff0c\u5728\u975c\u8108\u6ce8\u5c04\u6975\u4f4e\u5291\u91cf\u7684\u8840\u7ba1\u751f\u9577\u56e0\u5b50\uff08VEGF\uff09\uff0c\u80fd\u5920\u4f7f\u5948\u7c73\u5316\u7642\u85e5\u7269\uff0d\u5fae\u8102\u9ad4\u5c0f\u7d05\u8393\uff08LipoDox\uff09\u5b89\u5168\u4e14\u6709\u6548\u5730\u8f38\u9001\u81f3\u8166\u7624\u90e8\u4f4d\uff0c\u6210\u529f\u627e\u5230\u9019\u628a\u958b\u555f\u8840\u8166\u969c\u58c1\u9632\u8b77\u7f69\u7684\u9470\u5319\u3002<\/p>\n

\"\"<\/p>\n

\u672c\u9662\u751f\u91ab\u6240\u8b1d\u6e05\u6cb3\u7814\u7a76\u5718\u968a\u65bc\u672c\uff08108\uff09\u5e741\u670815\u65e5\u8209\u8fa6\u8a18\u8005\u6703\uff0c\u767c\u8868\u5275\u65b0\u8166\u7624\u6cbb\u7642\u7814\u7a76\u6210\u679c\u3002\u8b1d\u6e05\u6cb3\u8868\u793a\uff0c\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff08glioblastoma multiforme\uff09\u662f\u4e00\u7a2e\u5e38\u898b\u4e5f\u662f\u6700\u81f4\u547d\u7684\u8166\u764c\uff0c\u5728\u78ba\u8a3a\u4e4b\u5f8c\uff0c\u60a3\u8005\u5f80\u5f80\u53ea\u5269\u4e0b12-15\u500b\u6708\u5de6\u53f3\u7684\u58fd\u547d\u3002\u4e3b\u8981\u662f\u56e0\u70ba\u60e1\u6027\u8166\u7624\u751f\u9577\u5feb\u901f\u4e14\u6975\u5177\u64f4\u6563\u4fb5\u72af\u6027\uff0c\u958b\u5200\u7121\u6cd5\u62ff\u6389\u5168\u90e8\u7684\u816b\u7624\uff0c\u5373\u4f7f\u5408\u4f75\u5316\u7642\u6216\u96fb\u7642\uff0c\u4ecd\u53ea\u6709\u4e0d\u52305%\u7684\u75c5\u4eba\u53ef\u4ee5\u6d3b\u8d85\u904e\u4e94\u5e74\u3002<\/p>\n

\u68d8\u624b\u7684\u662f\uff0c\u76ee\u524d\u81e8\u5e8a\u4e0a\u4e00\u822c\u5e38\u7528\u7684\u5316\u7642\u85e5\u7269\u5e7e\u4e4e\u90fd\u7121\u6cd5\u4f7f\u7528\uff0c\u56e0\u70ba\u85e5\u7269\u975c\u8108\u6ce8\u5c04\u5f8c90%\u4ee5\u4e0a\u6703\u88ab\u8166\u90e8\u7279\u6709\u7684\u300c\u8840\u8166\u969c\u58c1\u300d\u963b\u9694\uff0c\u7121\u6cd5\u7a7f\u900f\u81f3\u816b\u7624\u90e8\u4f4d\u4ee5\u7522\u751f\u7642\u6548\u3002\u800c\u76ee\u524d\u81e8\u5e8a\u4e0a\u53ef\u7528\u7684\u5316\u7642\u85e5\u5e1d\u76df\u591a\uff08Temozolomide\uff09\u96d6\u6709\u8f03\u597d\u7684\u8840\u8166\u969c\u58c1\u7a7f\u900f\u6027\uff0c\u537b\u6709\u5c07\u8fd170 %\u7684\u75c5\u4eba\u5176\u764c\u7d30\u80de\u6703\u7522\u751f\u6297\u85e5\u6027\u3002<\/p>\n

\u8b1d\u6e05\u6cb3\u5718\u968a\u539f\u672c\u4ee5\u5e79\u7d30\u80de\u8207\u5fc3\u808c\u518d\u751f\u7814\u767c\u70ba\u4e3b\uff0c\u4f462012\u5e74\u767c\u8868\u65bc\u79d1\u5b78\u8f49\u8b6f\u91ab\u5b78\u96dc\u8a8c\u7684\u7814\u7a76\u4e2d\uff0c\u610f\u5916\u767c\u73fe\u5728\u5fc3\u81df\u6ce8\u5c04\u300c\u8840\u7ba1\u751f\u9577\u56e0\u5b50\u300d\uff0c\u53ef\u77ed\u66ab\u4f46\u660e\u986f\u5730\u589e\u52a0\u5948\u7c73\u7c92\u5b50\u901a\u904e\u8840\u8166\u969c\u58c1\u7684\u7a0b\u5ea6\u3002\u8b1d\u6e05\u6cb3\u56e0\u6b64\u7a81\u767c\u5947\u60f3\uff0c\u6216\u8a31\u53ef\u5c07\u6b64\u767c\u73fe\u61c9\u7528\u65bc\u4fc3\u9032\u8166\u90e8\u6838\u78c1\u5171\u632f\u986f\u5f71\u8207\u5316\u7642\u85e5\u7269\u8f38\u9001\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u6307\u51fa\uff0c\u5373\u4f7f\u627e\u5230\u958b\u555f\u8840\u8166\u969c\u58c1\u7684\u65b9\u6cd5\uff0c\u4e5f\u5f97\u300c\u96a8\u624b\u95dc\u9580\u300d\u3002\u56e0\u70ba\u8840\u8166\u969c\u58c1\u5728\u7dad\u6301\u5927\u8166\u751f\u7406\u5e73\u8861\u8207\u795e\u7d93\u7cfb\u7d71\u4fdd\u8b77\u529f\u80fd\u4e0a\u626e\u6f14\u95dc\u9375\u89d2\u8272\uff0c\u82e5\u6253\u958b\u9632\u8b77\u7f69\u592a\u4e45\uff0c\u53ef\u80fd\u5f15\u9032\u5371\u96aa\u7269\u8cea\u9032\u5165\u5927\u8166\uff0c\u50b7\u5bb3\u4eba\u9ad4\uff0c\u5fc5\u9808\u8b39\u614e\u62ff\u634fVEGF\u5291\u91cf\u7684\u9078\u64c7\u8207\u5f8c\u7e8c\u85e5\u7269\u975c\u8108\u7684\u6ce8\u5c04\u6642\u9593\u3002<\/p>\n

\"\"<\/p>\n

\u8b1d\u6e05\u6cb3\u5718\u968a\u5148\u5229\u7528\u8001\u9f20\u5be6\u9a57\uff0c\u8b49\u660e\u975c\u8108\u6ce8\u5c04\u6975\u4f4e\u5291\u91cf\u7684\u8840\u7ba1\u751f\u9577\u56e0\u5b50\uff08\u6bcf\u514b\u9ad4\u91cd\u6ce8\u5c041.5 ng VEGF\uff09\uff0c\u53ef\u572845\u5206\u9418\u5f8c\u77ed\u66ab\u5730\u6253\u958b\u8840\u8166\u969c\u58c1\uff0c\u589e\u52a0\u8840\u6db2\u5faa\u74b0\u4e2d\u5948\u7c73\u7c92\u5b50\u3001\u9020\u5f71\u5291\u3001\u6297\u9ad4\u8207\u5fae\u8102\u9ad4\u5316\u7642\u85e5\u7269\u9032\u5165\u5927\u8166\u7684\u7a0b\u5ea6\u7d043.5\u500d\uff1b\u800c\u8840\u8166\u969c\u58c1\u6703\u5728\u7d042\u5c0f\u6642\u5167\u81ea\u52d5\u95dc\u9589\uff0c\u4ee5\u514d\u7522\u751f\u526f\u4f5c\u7528\u3002\u4ed6\u6bd4\u55bb\uff0c\u300c\u5c31\u50cf\u829d\u9ebb\u958b\u9580\u3001\u829d\u9ebb\u95dc\u9580\u7684\u5bc6\u8a9e\u4e00\u6a23\u300d\uff1b\u4e5f\u5c07\u6b64\u767c\u73fe\u61c9\u7528\u65bc\u862d\u5dbc\u8ff7\u4f60\u8c6c\u7684\u5be6\u9a57\u4e2d\uff0c\u8b49\u5be6\u53ef\u63d0\u9ad8\u8166\u90e8\u6838\u78c1\u5171\u632f\u986f\u5f71\u8207\u5316\u7642\u85e5\u7269\u8f38\u9001\u81f3\u8c6c\u8166\u7684\u5291\u91cf\u5404\u7d042.5\u500d\u3002<\/p>\n

\u70ba\u4e86\u9032\u4e00\u6b65\u8a66\u9a57\u9019\u9805\u6280\u8853\u662f\u5426\u80fd\u88ab\u7528\u65bc\u6cbb\u7642\u60e1\u6027\u8166\u7624\uff0c\u8b1d\u6e05\u6cb3\u5718\u968a\u5229\u7528\u7acb\u9ad4\u5b9a\u4f4d\u986f\u5fae\u624b\u8853\u5c07\u4eba\u985e\u81a0\u8cea\u6bcd\u816b\u7624\u7d30\u80de\u690d\u5165\u57fa\u56e0\u8f49\u6b96\u514d\u75ab\u4e0d\u5168\u7684\u8001\u9f20\u5927\u8166\u4e2d\uff0c\u767c\u73fe\u764c\u7d30\u80de\u6703\u9020\u6210\u8001\u9f20\u5feb\u901f\u6b7b\u4ea1\uff0c\u5e73\u5747\u58fd\u547d\u4e0d\u523040\u5929\u3002\u800c\u900f\u904e\u8840\u7ba1\u751f\u9577\u56e0\u5b50\u7d50\u5408\u5fae\u8102\u9ad4\u5c0f\u7d05\u8393\u7684\u5169\u6ce2\u5f0f\u6cbb\u7642\uff0c\u4e0d\u50c5\u53ef\u4ee5\u63d0\u9ad8\u5316\u7642\u85e5\u7269\u9032\u5165\u816b\u7624\u7684\u5291\u91cf\u905413.6\u500d\uff0c\u540c\u6642\u5ef6\u9577\u8001\u9f20\u5e73\u5747\u58fd\u547d\u81f365\u5929\u3002\u63a5\u8457\uff0c\u5718\u968a\u767c\u5c55\u51fa\u8840\u7ba1\u751f\u9577\u56e0\u5b50\u591a\u6b21\u6ce8\u5c04\u7684\u591a\u6bb5\u5f0f\u6cbb\u7642\uff08\u6bcf3\u5c0f\u6642\u829d\u9ebb\u958b\u9580\u4e00\u6b21\uff09\uff0c\u4e0d\u50c5\u6c92\u6709\u7522\u751f\u660e\u986f\u526f\u4f5c\u7528\u3001\u4e0d\u7528\u589e\u52a0\u5316\u7642\u85e5\u7269\u7528\u91cf\u3001\u816b\u7624\u8fc5\u901f\u7e2e\u5c0f\uff0c\u751a\u81f3\u53ef\u4ee5\u5c07\u8001\u9f20\u5e73\u5747\u58fd\u547d\u5ef6\u9577\u81f380\u5929\uff01<\/p>\n

\"\"<\/p>\n

\u8b1d\u6e05\u6cb3\u8868\u793a\uff0c\u4ed6\u5728\u7f8e\u570b\u7684\u535a\u58eb\u8ad6\u6587\u6307\u5c0e\u6559\u6388Dr. Alec Clowes\u7f79\u60a3\u8166\u764c\uff0c\u539f\u672c\u5e0c\u671b\u9019\u9805\u6280\u8853\u80fd\u5c0d\u8001\u5e2b\u7684\u75c5\u60c5\u6709\u6240\u5e6b\u52a9\uff0c\u53ef\u60dcDr. Clowes\u5df2\u7d93\u5728\u4e09\u5e74\u524d\u96e2\u4e16\u3002\u4ed6\u5c07\u8207\u5718\u968a\u7e7c\u7e8c\u52aa\u529b\uff0c\u52a0\u901f\u9032\u884c\u4eba\u9ad4\u81e8\u5e8a\u8a66\u9a57\uff0c\u628a\u5c0d\u8001\u5e2b\u7684\u611f\u8b1d\u5316\u70ba\u5927\u611b\uff0c\u9020\u798f\u66f4\u591a\u60e1\u6027\u8166\u7624\u60a3\u8005\u3002<\/p>\n

\u672c\u8ad6\u6587\u7b2c\u4e00\u4f5c\u8005\u85cd\u8fea\u5c09\uff08David Lundy\uff09\u70ba\u672c\u9662\u751f\u91ab\u6240\u524d\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\uff0c\u73fe\u70ba\u81fa\u5317\u91ab\u5b78\u5927\u5b78\u52a9\u7406\u6559\u6388\uff0c\u7814\u7a76\u5718\u968a\u6210\u54e1\u9664\u751f\u91ab\u6240\u674e\u5e9a\u878d\u7b49\u7814\u7a76\u4eba\u54e1\u5916\uff0c\u9084\u5305\u62ec\u81fa\u5927\u91ab\u9662\u5916\u79d1\u7530\u90c1\u6587\u91ab\u5e2b\u3002\u7814\u7a76\u7d93\u8cbb\u7531\u79d1\u6280\u90e8\u3001\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u53ca\u672c\u9662\u652f\u6301\u3002<\/p>\n

\u672c\u7814\u7a76\u53ef\u671b\u70ba\u6cbb\u7642\u60e1\u6027\u8166\u7624\u60a3\u8005\u5e36\u4f86\u65b0\u5951\u6a5f\uff0c\u4e26\u65bc\u53bb\uff08107\uff09\u5e7412\u670811\u65e5\u520a\u8f09\u65bc\u300a\u7f8e\u570b\u5316\u5b78\u6703\u5948\u7c73\u96dc\u8a8c\u300b\uff08ACS Nano\uff09<\/em><\/strong>\uff0c\u6587\u7ae0\u6a19\u984c\u70ba\u3008Inducing a Transient Increase in Blood Brain Barrier Permeability for Improved Liposomal Drug Therapy of Glioblastoma Multiforme\u3009\u3002<\/p>\n

 <\/p>\n

\"\"
\n\u25b2 \u8b1d\u6e05\u6cb3\u5718\u968a\u900f\u904e\u8840\u7ba1\u751f\u9577\u56e0\u5b50\u7d50\u5408\u5fae\u8102\u9ad4\u5c0f\u7d05\u8393\u7684\u5169\u6ce2\u5f0f\u6cbb\u7642\uff0c\u6709\u6548\u7a81\u7834\u8840\u8166\u969c\u58c1\uff0c\u63d0\u9ad8\u5316\u7642\u85e5\u7269\u9032\u5165\u816b\u7624\u7684\u5291\u91cf\uff0c\u540c\u6642\u5ef6\u9577\u8001\u9f20\u5e73\u5747\u58fd\u547d\u3002<\/p>\n

 <\/p>\n

 <\/p>\n

\uff08\u6587\uff1a\u751f\u91ab\u6240\u3001\u79d8\u66f8\u8655\uff1b\u651d\u5f71\uff1a\u8cc7\u8a0a\u8655\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

\u8840\u8166\u969c\u58c1\uff08blood brain barrier\uff09\u662f\u8166\u7624\u6cbb\u7642\u7684\u4e3b\u8981\u969c\u7919\uff0c\u5316\u7642\u85e5\u7269\u88ab\u963b\u9694\u5728\u5916\uff0c\u7121\u6cd5\u6709\u6548\u6bba\u6b7b\u764c\u7d30\u80de […]<\/p>\n","protected":false},"author":1,"featured_media":16141,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/16137"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=16137"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/16137\/revisions"}],"predecessor-version":[{"id":16182,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/16137\/revisions\/16182"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/16141"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=16137"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=16137"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=16137"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}