{"id":15770,"date":"2018-12-20T00:00:24","date_gmt":"2018-12-19T16:00:24","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=15770"},"modified":"2021-08-12T11:00:30","modified_gmt":"2021-08-12T03:00:30","slug":"%e6%96%b0%e9%80%b2%e4%ba%ba%e5%93%a1%e4%bb%8b%e7%b4%b9-%e7%94%9f%e7%89%a9%e5%8c%96%e5%ad%b8%e7%a0%94%e7%a9%b6%e6%89%80%e5%8a%a9%e7%a0%94%e7%a9%b6%e5%93%a1%e5%90%b3%e6%98%86%e5%b3%af%e5%8d%9a","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/15770\/","title":{"rendered":"\u65b0\u9032\u4eba\u54e1\u4ecb\u7d39\uff0d\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u52a9\u7814\u7a76\u54e1\u5433\u6606\u5cef\u535a\u58eb"},"content":{"rendered":"<p><a href=\"http:\/www.ibc.sinica.edu.tw\/PI_DetailC.asp?Auto=62\"><strong>\u5433\u6606\u5cef<\/strong><\/a>\u65bc2010\u5e74\u7372\u5f97\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7acb\u7f85\u683c\u65af\u5927\u5b78\u5316\u5b78\u8207\u5316\u5b78\u751f\u7269\u7cfb\u535a\u58eb\u5b78\u4f4d\u3002\u5176\u7814\u7a76\u5c08\u9577\u70ba\u751f\u7269\u7269\u7406\u8207\u86cb\u767d\u8cea\u5316\u5b78\uff1b\u7814\u7a76\u4e3b\u984c\u70ba\u6cdb\u7d20\u8207\u5f8c\u8f49\u9304\u4fee\u98fe\u76f8\u95dc\u75be\u75c5\u3002\u5f8c\u8f49\u9304\u4fee\u98fe\u5728\u751f\u7269\u9ad4\u5167\u626e\u6f14\u4e86\u76f8\u7576\u91cd\u8981\u7684\u529f\u80fd\u8abf\u63a7\u89d2\u8272\uff0c\u8209\u51e1\u78f7\u9178\u4fee\u98fe\u3001\u7532\u57fa\u4fee\u98fe\u3001\u91a3\u4fee\u98fe\u7b49\u90fd\u4f7f\u7528\u5c0f\u5206\u5b50\u5728\u86cb\u767d\u8cea\u7684\u7279\u5b9a\u4f4d\u7f6e\u4fee\u98fe\u3002\u6cdb\u7d20(ubiquitin) \u6a19\u8a18\u63a1\u7528\u4e00\u500b76\u9846\u6c28\u57fa\u9178\u7684\u6cdb\u7d20\uff0c\u4fee\u98fe\u5728\u7279\u5b9a\u86cb\u767d\u8cea\u4e0a\u9762\u3002\u8fd1\u534a\u4eba\u9ad4\u5167\u7684\u86cb\u767d\u8cea\u90fd\u6703\u88ab\u6cdb\u7d20\u4fee\u98fe\uff0c\u5176\u4fee\u98fe\u7522\u7269\u6703\u88ab\u5e36\u5f80\u7d30\u80de\u5167\u7684\u86cb\u767d\u9176\u9ad4\u8655\u7406\uff0c\u5982\u540c\u7d30\u80de\u5167\u7684\u788e\u7d19\u6a5f\u628a\u86cb\u767d\u8cea\u7d5e\u788e\u5f8c\uff0c\u56de\u6536\u6c28\u57fa\u9178\u518d\u5229\u7528\u3002\u5728\u5148\u5929\u514d\u75ab(innate immune)\u7cfb\u7d71\u4e2d\uff0c\u6709\u4e00\u7a2e\u4e0d\u540c\u65bc\u4e00\u822c\u7684\u6cdb\u7d20\u4fee\u98fe\u7cfb\u7d71ISG15\u3002\u9019\u7d44\u7279\u5225\u7684\u985e\u6cdb\u7d20\u7cfb\u7d71\u5c08\u8cac\u5c0d\u6297\u75c5\u6bd2\u53ca\u7d30\u83cc\u7684\u4fb5\u8972\u3002\u662f\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u4e2d\u7b2c\u4e00\u9053\u9632\u79a6\u6230\u7dda\u3002\u8209\u4f8b\u4f86\u8aaa\uff0c\u611f\u5192\u75c5\u6bd2\u6216\u767b\u9769\u71b1\u75c5\u6bd2\u5728\u4fb5\u5165\u514d\u75ab\u7cfb\u7d71\u5f8c\uff0c\u5e72\u64fe\u7d20\u6d3b\u5316\u7684ISG15 \u7cfb\u7d71\u6703\u555f\u52d5\u4e00\u7cfb\u5217\u7684\u6297\u79a6\u6a5f\u5236\u4fc3\u4f7f\u514d\u75ab\u7cfb\u7d71\u4ee3\u8b1d\u5916\u4f86\u75c5\u539f\u9ad4\u7684\u86cb\u767d\u8cea\uff0c\u6700\u7d42\u964d\u4f4e\u75c5\u6bd2\u6216\u75c5\u83cc\u7684\u589e\u751f\u3002\u985e\u6cdb\u7d20\u53cd\u61c9\u7d30\u7bc0\u6709\u5f85\u91d0\u6e05\uff0c\u85c9\u7531\u5148\u9032\u7684\u751f\u7269\u7269\u7406\u5100\u5668(NMR, cryoEM and synchrotron)\uff0c\u63a2\u8a0e\u86cb\u767d\u8cea\u9593\u7684\u7d30\u5fae\u4e92\u52d5\u8207\u6d3b\u5316\u8abf\u63a7\u7684\u7d30\u7bc0\uff0c\u8a73\u77e5\u985e\u6cdb\u7d20\u514d\u75ab\u53cd\u61c9\u7684\u6a5f\u5236\u8207\u767c\u5c55\u6297\u79a6\u75c5\u539f\u9ad4\u7684\u65b9\u6cd5\u3002<\/p>\n<p>\u5433\u535a\u58eb\u81ea107\u5e7411\u6708\u8d77\u65bc\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u64d4\u4efb\u52a9\u7814\u7a76\u54e1\u4e00\u8077\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5433\u6606\u5cef\u65bc2010\u5e74\u7372\u5f97\u7f8e\u570b\u65b0\u6fa4\u897f\u5dde\u7acb\u7f85\u683c\u65af\u5927\u5b78\u5316\u5b78\u8207\u5316\u5b78\u751f\u7269\u7cfb\u535a\u58eb\u5b78\u4f4d\u3002\u5176\u7814\u7a76\u5c08\u9577\u70ba\u751f\u7269\u7269\u7406\u8207\u86cb\u767d\u8cea\u5316\u5b78\uff1b\u7814\u7a76 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":15774,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[103],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/15770"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=15770"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/15770\/revisions"}],"predecessor-version":[{"id":16255,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/15770\/revisions\/16255"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/15774"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=15770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=15770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=15770"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}