{"id":14806,"date":"2018-09-27T09:04:46","date_gmt":"2018-09-27T01:04:46","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=14806"},"modified":"2021-08-12T15:28:20","modified_gmt":"2021-08-12T07:28:20","slug":"%e5%90%83%e8%b6%8a%e5%b0%91%e8%b6%8a%e5%ae%b9%e6%98%93%e7%98%a6%ef%bc%9f%e6%b8%9b%e9%87%8d%e9%82%84%e9%9c%80%e6%90%ad%e9%85%8d%e9%ab%94%e5%85%a7%e3%80%8c%e8%80%97%e8%83%bd%e6%a9%9f%e5%88%b6","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/14806\/","title":{"rendered":"\u5403\u8d8a\u5c11\u8d8a\u5bb9\u6613\u7626\uff1f\u6e1b\u91cd\u9084\u9700\u642d\u914d\u9ad4\u5167\u300c\u8017\u80fd\u6a5f\u5236\u300d \u4e2d\u7814\u9662\u7814\u7a76\u767c\u73fe\u68d5\u8272\u8102\u80aa\u7684\u4ee3\u8b1d\u65b9\u7a0b\u5f0f"},"content":{"rendered":"<p>\u6e1b\u91cd\u7684\u6210\u6548\u4e0d\u50c5\u8207\u98f2\u98df\u91cf\u6709\u95dc\uff0c\u4e5f\u53d6\u6c7a\u65bc\u8eab\u9ad4\u4ee3\u8b1d\u8207\u8017\u80fd\u7684\u6548\u7387\u3002\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u9ec3\u6021\u8431\u526f\u7814\u7a76\u54e1\u5718\u968a\u8fd1\u671f\u767c\u73fe\u4e00\u5957\u300c\u8017\u80fd\u6a5f\u5236\u300d\uff0c\u5728\u54fa\u4e73\u985e\u52d5\u7269\u7684\u68d5\u8272\u8102\u80aa\u7d30\u80de\u4e2d\uff0cCPEB2\u86cb\u767d\u6703\u8207UCP1 mRNA\u76f8\u4e92\u4f5c\u7528\uff0c\u4fc3\u9032\u8eab\u9ad4\u8017\u80fd\u3002\u5be6\u9a57\u7d50\u679c\u4e5f\u9032\u4e00\u6b65\u767c\u73fe\uff0c\u904e\u5ea6\u7bc0\u98df\u6050\u56e0\u964d\u4f4e\u8eab\u9ad4\u7684\u8017\u80fd\u6548\u7387\uff0c\u5c0e\u81f4\u6e1b\u91cd\u6548\u679c\u4e0d\u5982\u9810\u671f\u3002<\/p>\n<p>\u54fa\u4e73\u985e\u52d5\u7269\u9ad4\u5167\u7684\u68d5\u8272\u8102\u80aa\u7d44\u7e54\u8ca0\u8cac\u6d88\u8017\u80fd\u91cf\u4ee5\u7dad\u6301\u9ad4\u6eab\uff0c\u5176\u6d3b\u6027\u8d8a\u9ad8\uff0c\u8eab\u9ad4\u7684\u4ee3\u8b1d\u7387\u4fbf\u8d8a\u597d\u3001\u9ad4\u8102\u80aa\u4e5f\u5c31\u8d8a\u4f4e\u3002\u5728\u68d5\u8272\u8102\u80aa\u7d30\u80de\u4e2d\uff0c\u86cb\u767d\u8ceaUCP1\u626e\u6f14\u8457\u95dc\u9375\u89d2\u8272\uff0c\u71c3\u71d2\u8eab\u9ad4\u7684\u5316\u5b78\u80fd\u7522\u751f\u71b1\u80fd\u3002\u904e\u53bb\u7814\u7a76\u5df2\u8b49\u5be6UCP1\u548c\u68d5\u8272\u8102\u80aa\u53ef\u5e6b\u52a9\u63a7\u5236\u9ad4\u91cd\u3002\u70ba\u9032\u4e00\u6b65\u63a2\u8a0eUCP1\u7684\u751f\u7522\u904e\u7a0b\uff0c\u9ec3\u6021\u8431\u5718\u968a\u5f9eUCP1\u7684mRNA\u958b\u59cb\u63a2\u7d22\u3002UCP1\u7684mRNA\u5728\u5c0f\u9f20\u9ad4\u5167\u6709\u9577\u3001\u77ed\u5169\u7a2e\u5f62\u5f0f\uff0c\u7d55\u5927\u591a\u6578\u662f\u77ed\u7684\uff0c\u50c5\u6709\u7d0410%\u70ba\u9577\u7684\u3002\u5718\u968a\u4ee5\u57fa\u56e0\u7de8\u8f2f\u6280\u8853\uff0c\u5c07\u5c0f\u9f20\u9ad4\u5167\u9577\u7684mRNA\u8f49\u63db\u6210\u77ed\u7684mRNA\u5f8c\u767c\u73fe\uff0c\u96d6\u7136UCP1 mRNA\u7684\u7e3d\u91cf\u4e0d\u8b8a\uff0c\u4f46UCP1\u86cb\u767d\u7684\u7522\u91cf\u7adf\u56e0\u6b64\u6e1b\u5c11\u5c07\u8fd160\uff05\u3002\u7531\u6b64\u53ef\u898b\uff0c\u70ba\u6578\u4e0d\u591a\u7684\u9577\u5f62mRNA\u624d\u662f\u88fd\u9020UCP1\u86cb\u767d\u7684\u95dc\u9375\u3002<\/p>\n<p>\u9ec3\u6021\u8431\u8868\u793a\uff1a\u300c\u4eba\u9ad4\u8207\u5c0f\u9f20\u4e0d\u540c\uff0c\u6070\u597d\u53ea\u6709\u9577\u7684mRNA\u3002\u53ef\u4ee5\u63a8\u6e2c\uff0c\u5176\u8abf\u63a7\u6a5f\u5236\u5c0d\u4eba\u985e\u7684\u80fd\u91cf\u4ee3\u8b1d\u66f4\u70ba\u91cd\u8981\u3002\u300d\u7814\u7a76\u5718\u968a\u4e5f\u900f\u904e\u5be6\u9a57\u89c0\u5bdf\u98f2\u98df\u8207\u74b0\u5883\u6eab\u5ea6\u5c0d\u5c0f\u9f20\u7522\u751fUCP1\u86cb\u767d\u8cea\u7684\u5f71\u97ff\uff0c\u4e26\u767c\u73fe\u9019\u5169\u7a2e\u523a\u6fc0\u4e5f\u662f\u4fc3\u9032CPEB2-UCP1\u6b64\u4e00\u8017\u80fd\u6a5f\u5236\u7684\u56e0\u7d20\u3002\u56e0\u6b64\uff0c\u904e\u5ea6\u7bc0\u98df\u6050\u56e0\u7121\u6cd5\u523a\u6fc0\u8017\u80fd\u6a5f\u5236\uff0c\u5c0e\u81f4\u6e1b\u91cd\u6548\u679c\u4e0d\u5f70\u3002\u7d93\u904e\u5c0f\u9f20\u5be6\u9a57\u8b49\u5be6\uff0cUCP1\u9577\u5f62\u7684mRNA\u8981\u6709\u6548\u7684\u7522\u751fUCP1\u86cb\u767d\uff0c\u9808\u900f\u904e\u8207CPEB2\u7d50\u5408\u800c\u53d7\u5176\u6b63\u5411\u8abf\u63a7\u3002\u900f\u904e\u5c0d\u6b64\u8017\u80fd\u6a5f\u5236\u7684\u77ad\u89e3\uff0c\u672a\u4f86\u4fbf\u5c07\u6709\u6a5f\u6703\u9032\u4e00\u6b65\u8abf\u63a7\uff0c\u4ee5\u6709\u6548\u4fc3\u9032\u4ee3\u8b1d\u6548\u7387\u3001\u63d0\u5347\u6e1b\u91cd\u6210\u6548\u3002<\/p>\n<p>\u6b64\u7814\u7a76\u6210\u679c\u5df2\u65bc\u672c\u5e749\u67083\u65e5\u520a\u767b\u65bc<em>EMBO J.<\/em>\u3002\u7b2c\u4e00\u53ca\u7b2c\u4e8c\u4f5c\u8005\u70ba\u9673\u93cf\u4ef9\u535a\u58eb\u5f8c\u7814\u7a76\u4eba\u54e1\u53ca\u8a31\u632f\u9298\u7814\u7a76\u52a9\u7406\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-14807\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/09\/01-0201.png\" alt=\"\" width=\"941\" height=\"332\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/09\/01-0201.png 941w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/09\/01-0201-300x106.png 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/09\/01-0201-768x271.png 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/09\/01-0201-270x95.png 270w\" sizes=\"(max-width: 941px) 100vw, 941px\" \/><\/p>\n<p>\u5716\u8aaa\uff1aUCP1\u7684mRNA\u8207CPEB2\u76f8\u4e92\u4f5c\u7528\uff0c\u7522\u751f\u66f4\u591aUCP1\u86cb\u767d\uff0c\u63d0\u5347\u8017\u80fd\u6548\u7387\uff0c\u63a7\u5236\u5c0f\u9f20\u9ad4\u91cd\u3002<\/p>\n<p>\uff08\u5716\uff0f\u6587\uff1a\u751f\u91ab\u6240\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6e1b\u91cd\u7684\u6210\u6548\u4e0d\u50c5\u8207\u98f2\u98df\u91cf\u6709\u95dc\uff0c\u4e5f\u53d6\u6c7a\u65bc\u8eab\u9ad4\u4ee3\u8b1d\u8207\u8017\u80fd\u7684\u6548\u7387\u3002\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u9ec3\u6021\u8431\u526f\u7814\u7a76\u54e1\u5718\u968a\u8fd1\u671f\u767c\u73fe\u4e00\u5957 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":14843,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/14806"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=14806"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/14806\/revisions"}],"predecessor-version":[{"id":16275,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/14806\/revisions\/16275"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/14843"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=14806"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=14806"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=14806"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}