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\u524d\u8a00<\/strong> \u7d44\u7e54\u9178\u5316\u8207\u75bc\u75db<\/strong> \u9178\u654f\u6027\u53d7\u9ad4\u819c\u86cb\u767d<\/strong> \u6162\u6027\u75bc\u75db\u7684\u5f62\u6210<\/strong> \u9178\u7684\u6b62\u75db\u4f5c\u7528<\/strong> \u9019\u500b\u201c\u9178\u6b62\u75db\u201d\u4f5c\u7528\u4f3c\u4e4e\u662f\u8a31\u591a\u6162\u6027\u75bc\u75db\u7684\u7b54\u6848\uff0c\u63d0\u4f9b\u4e86\u6b62\u75db\u85e5\u958b\u767c\u7684\u65b0\u65b9\u5411\u3002\u9019\u4e5f\u8a31\u53ef\u4ee5\u89e3\u91cb\u70ba\u751a\u9ebc\u6709\u4e9b\u6162\u6027\u75bc\u75db\u4e00\u65e6\u88ab\u8a98\u767c\uff0c\u5c31\u8b8a\u6210\u9811\u6297\u578b\u7684\u75bc\u75db\u3002<\/p>\n \u75e0\u6216\u75db\uff1f<\/strong> \u7d50\u8a9e<\/strong> \u6df1\u5165\u95b1\u8b80<\/strong> <\/p>\n \u5716\u4e00\uff1a\u75db\u89ba\u795e\u7d93\u4e0a\u7684\u56db\u5927\u985e\u9178\u654f\u6027\u53d7\u9ad4\u819c\u86cb\u767d<\/p>\n <\/p>\n \u5716\u4e8c\uff1a\u9178\u7684\u81f4\u75db\u8207\u6b62\u75db\u8a0a\u606f<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u4f5c\u8005 \uff0f \u9673\u5fd7\u6210\uff0f\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u7814\u7a76\u54e1 \u6458\u8981 \u5e7e\u4e4e\u6bcf\u500b\u4eba\u90fd\u6703\u6709\u75e0\u75db\u7684\u56f0\u64fe\uff0c\u4f46\uff0c\u75e0\u75db\u611f\u89ba\u5982\u4f55\u7522\u751f\u8207\u50b3\u905e\uff1f\u75e0\u75db […]<\/p>\n","protected":false},"author":1,"featured_media":14729,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[991,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/14727"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=14727"}],"version-history":[{"count":2,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/14727\/revisions"}],"predecessor-version":[{"id":14821,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/14727\/revisions\/14821"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/14729"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=14727"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=14727"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=14727"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}
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\n\u75e0\u75db\u5f88\u5bb9\u6613\u806f\u60f3\u5230\u7d44\u7e54\u9178\u5316\uff08\u9020\u6210\u6c2b\u96e2\u5b50\u6fc3\u5ea6\u7684\u589e\u52a0\uff09\uff1a\u7576\u7d44\u7e54\u53d7\u50b7\u3001\u7f3a\u8840\u3001\u767c\u708e\uff0c\u6703\u7522\u751f\u7d44\u7e54\u9178\u5316\u4e26\u4f34\u96a8\u8457\u75bc\u75db\u3002\u81e8\u5e8a\u4e0a\u7684\u89c0\u5bdf\uff0c\u8a31\u591a\u75bc\u75db\u90fd\u8207\u7d44\u7e54\u9178\u5316\u76f8\u95dc\u3002\u50cf\u662f\u6fc0\u70c8\u904b\u52d5\u5f8c\u7684\u808c\u8089\u75e0\u75db\u3001\u95dc\u7bc0\u767c\u708e\u6240\u8a98\u767c\u7684\u75bc\u75db\u3001\u808c\u7b4b\u819c\u75bc\u75db\u3001\u5fc3\u7d5e\u75db\u3001\u7b49\u7b49\u3002\u7136\u800c\uff0c\u76f4\u52301996\u5e74\u5fb7\u570b\u79d1\u5b78\u5bb6\u624d\u9996\u6b21\u5efa\u7acb\u7d44\u7e54\u9178\u5316\u8207\u75bc\u75db\u7684\u56e0\u679c\u95dc\u4fc2\u3002\u5f8c\u7e8c\u8a31\u591a\u81e8\u5e8a\u7814\u7a76\uff0c\u4e5f\u8b49\u660e\u7d44\u7e54\u9178\u5316\u7684\u78ba\u6703\u8a98\u767c\u75bc\u75db\u3002\u7136\u800c\uff0c\u9178\u662f\u900f\u904e\u4ec0\u9ebc\u6a23\u7684\u5206\u5b50\u6a5f\u5236\u4f86\u523a\u6fc0\u75db\u89ba\u795e\u7d93\uff0c\u537b\u4e00\u76f4\u6c92\u6709\u5b9a\u8ad6\u3002\u518d\u8005\uff0c\u9178\u6240\u8a98\u767c\u7684\u75bc\u75db\uff0c\u662f\u5426\u5c31\u662f\u6211\u5011\u6163\u7a31\u7684\u75e0\u75db\uff1f\u76ee\u524d\u4e5f\u9084\u7121\u6cd5\u8b49\u5be6\u3002<\/p>\n
\n\u6211\u5011\u4eba\u9ad4\u8eab\u4e0a\u5404\u500b\u7d44\u7e54\u90fd\u4f48\u6eff\u8457\u75db\u89ba\u795e\u7d93\u3001\u4e0a\u9762\u6709\u8a31\u591a\u53ef\u88ab\u9178\u7d66\u6fc0\u6d3b\u7684\u96e2\u5b50\u901a\u9053\u6216\u53d7\u9ad4\u5206\u5b50\u3002\u65e9\u57281980\u5e74\u4ee3\u521d\u671f\uff0c\u70cf\u514b\u862d\u79d1\u5b78\u5bb6Kristal \u5229\u7528\u7d30\u80de\u96fb\u751f\u7406\u7684\u65b9\u6cd5\uff0c\u9996\u6b21\u767c\u73fe\u9178\u53ef\u4ee5\u6fc0\u6d3b\u611f\u89ba\u795e\u7d93\u7d30\u80de\uff0c\u4f7f\u5176\u7522\u751f\u96fb\u6d41\u4e26\u8a98\u767c\u52d5\u4f5c\u96fb\u4f4d\u3002\u5f8c\u7e8c\u8a31\u591a\u7814\u7a76\u767c\u73fe\uff0c\u75db\u89ba\u795e\u7d93\u7d30\u80de\u5c0d\u9178\u7684\u523a\u6fc0\u662f\u76f8\u7576\u654f\u611f\u7684\uff0c\u56e0\u800c\u63d0\u4f9b\u4e86\u9178\u53ef\u8a98\u767c\u75bc\u75db\u7684\u4e00\u500b\u91cd\u8981\u7684\u795e\u7d93\u751f\u7269\u5b78\u57fa\u790e\u3002\u5728\u5206\u5b50\u7684\u5c64\u9762\u4e0a\uff0c\u76ee\u524d\u5df2\u77e5\u6709\u56db\u5927\u985e\u7684\u53d7\u9ad4\u819c\u86cb\u767d\u8868\u73fe\u5728\u75db\u89ba\u795e\u7d93\u5143\u4e0a\uff1a\u5206\u5225\u662f\uff08\u4e00\uff09\u9178\u654f\u6027\u96e2\u5b50\u901a\u9053(ASIC)\uff1b\uff08\u4e8c\uff09\u8fa3\u6912\u7d20\u53d7\u9ad4\u86cb\u767d\uff1b\uff08\u4e09\uff09\u9178\u654f\u6027G\u86cb\u767d\u8026\u548c\u53d7\u9ad4\uff1b\uff08\u56db\uff09\u96d9\u5b54\u9240\u96e2\u5b50\u901a\u9053\uff08\u5716\u4e00\uff09\u3002\u5176\u4e2d\uff0c\u9178\u654f\u6027\u96e2\u5b50\u901a\u9053\u56e0\u5927\u91cf\u8868\u73fe\u5728\u75db\u89ba\u795e\u7d93\u7d30\u80de\u4e0a\uff0c\u76f8\u8f03\u4e8e\u5176\u4ed6\u9178\u654f\u6027\u53d7\u9ad4\u819c\u86cb\u767d\uff0c\u5c0d\u9178\u4ea6\u76f8\u5c0d\u654f\u611f\uff0c\u56e0\u800c\u6700\u53d7\u77da\u76ee\u3002\u9178\u654f\u6027\u96e2\u5b50\u901a\u9053\u57281996\u5e74\u88ab\u767c\u73fe\uff0c\u5df2\u77e5\u6709\u516d\u500b\u4e9e\u578b\uff0c\u5206\u5225\u70ba\uff1aASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4\u3002\u4e00\u500b\u5b8c\u6574\u7684\u9178\u654f\u6027\u96e2\u5b50\u901a\u9053\u9700\u7531\u4e09\u500b\u55ae\u9ad4\u7d44\u6210\uff1a\u53ef\u4ee5\u662f\u4e09\u500b\u76f8\u540c\u6216\u4e0d\u540cASIC\u4e9e\u578b\u7684\u7d44\u5408\u3002\u4f9d\u64da\u6240\u7d44\u6210\u7684ASIC\u4e9e\u578b\uff0c\u9178\u654f\u6027\u96e2\u5b50\u901a\u9053\u5c0d\u7d44\u7e54\u9178\u5316\u7684\u654f\u611f\u5ea6\u53ef\u5f9e\u63a5\u8fd1\u751f\u7406\u7684\u9178\u9e7c\u503c(~pH7.2) \u5230\u975e\u5e38\u56b4\u91cd\u7684\u7d44\u7e54\u9178\u5316(\u2264pH5.0)\u3002\u56e0\u6b64\uff0c\u4e0d\u540c\u7684\u611f\u89ba\u795e\u7d93\u7e96\u7dad\u6703\u56e0\u7d44\u7e54\u5206\u4f48\u7684\u4e0d\u540c\uff0c\u800c\u914d\u5099\u4e0d\u540c\u9178\u654f\u611f\u5ea6\u7684\u9178\u654f\u6027\u96e2\u5b50\u901a\u9053\u3002\u4f8b\u5982\uff0c\u5206\u4f48\u4e8e\u808c\u8089\u7684\u75db\u89ba\u795e\u7d93\u7e96\u7dad\uff0c\u5927\u90fd\u8868\u73feASIC3\u4e9e\u578b\uff0c\u9019\u662f\u6240\u6709ASIC\u4e9e\u578b\u4e2d\uff0c\u5c0d\u9178\u654f\u611f\u5ea6\u6700\u597d\u7684(pH0.5=6.7)\u3002\u8a31\u591a\u52d5\u7269\u5be6\u9a57\u4ea6\u8b49\u5be6\uff0c\u808c\u8089\u75db\u89ba\u795e\u7d93\u7684ASIC3\u662f\u9178\u53ef\u8a98\u767c\u6162\u6027\u75bc\u75db\u7684\u4e3b\u8981\u56e0\u5b50\u3002\u5728\u6162\u6027\u75bc\u75db\u7684\u52d5\u7269\u6a21\u5f0f\u4e2d\uff08\u4f8b\u5982\u808c\u8089\u8edf\u7d44\u7e54\u7d44\u7e54\u767c\u708e\u3001\u8853\u5f8c\u75bc\u75db\u3001\u808c\u8089\u75e0\u75db\uff09\uff0c\u6291\u5236ASIC3\u6216\u5c07\u4e4b\u57fa\u56e0\u5254\u9664\u5f8c\uff0c\u53ef\u5b8c\u5168\u963b\u6b62\u9178\u6240\u8a98\u767c\u7684\u6162\u6027\u75bc\u75db\u3002<\/p>\n
\n\u52d5\u7269\u5be6\u9a57\u7684\u7d50\u679c\u986f\u793a\uff0c\u4e0a\u8ff0\u9019\u4e9b\u9178\u654f\u6027\u53d7\u9ad4\u819c\u86cb\u767d\u8207\u75bc\u75db\u7684\u95dc\u4fc2\u975e\u5e38\u5bc6\u5207\u3002\u8209\u7e96\u7dad\u808c\u75db\u75c7\u52d5\u7269\u6a21\u5f0f\u70ba\u4f8b\uff0c\u5728\u5be6\u9a57\u5c0f\u9f20\u55ae\u5074\u8153\u8178\u808c\u5167\u6ce8\u5c04pH4.0\u751f\u7406\u98df\u9e7d\u6c34\u5f8c\uff0c\u6703\u5728\u540c\u5074\u8207\u5c0d\u5074\u7684\u8153\u8178\u808c\u4ee5\u53ca\u5f8c\u80a2\u8173\u638c\uff0c\u5747\u8a98\u767c\u6a5f\u68b0\u6027\u75bc\u75db\u904e\u654f\u5316\u73fe\u8c61\uff1b\u610f\u5373\u8a98\u767c\u4e86\u539f\u767c\u6027\u75bc\u75db\u904e\u654f\u5316 (primary hyperalgesia)\u3001\u7e8c\u767c\u6027\u75bc\u75db\u904e\u654f\u5316 (secondary hyperalgesia)\u3001\u8207\u93e1\u50cf\u75bc\u75db (mirror imaging pain)\u3002\u96d6\u7136\u9019\u7a2e\u808c\u8089\u5167\u7d44\u7e54\u9178\u5316\u6240\u8a98\u767c\u7684\u75bc\u75db\u904e\u654f\u5316\u73fe\u8c61\u50c5\u6301\u7e8c\u5e7e\u500b\u5c0f\u6642\uff0c\u5047\u5982\u4e94\u5929\u5167\u5728\u540c\u4e00\u4f4d\u7f6e\u6ce8\u5c04\u540c\u4e00\u5291\u91cf\u7684\u9178\u6027\u751f\u7406\u98df\u9e7d\u6c34\uff0c\u5c31\u6703\u8a98\u767c\u6162\u6027\u75bc\u75db\u904e\u654f\u5316\uff0c\u4e26\u6301\u7e8c\u56db\u5468\u5de6\u53f3\u3002\u9019\u500b\u7e96\u7dad\u808c\u75db\u75c7\u5be6\u9a57\u6a21\u5f0f\u63d0\u4f9b\u4e86\u4e00\u500b\u5e73\u53f0\uff0c\u4f86\u9a57\u8b49\u7d44\u7e54\u9178\u5316\u662f\u5982\u4f55\u8a98\u767c\u6162\u6027\u808c\u8089\u75bc\u75db\uff0c\u4ee5\u53ca\u5404\u7a2e\u9178\u654f\u6027\u53d7\u9ad4\u86cb\u767d\u5728\u9019\u904e\u7a0b\u4e2d\u6240\u626e\u6f14\u7684\u89d2\u8272\u3002\u4e0a\u8ff0\u63d0\u5230ASIC3\u5c31\u662f\u5176\u4e2d\u6700\u91cd\u8981\u7684\u4e00\u500b\u95dc\u9375\u5206\u5b50\u3002\u7576ASIC3\u57fa\u56e0\u5254\u9664\u5f8c\uff0c\u5be6\u9a57\u5c0f\u9f20\u5b8c\u5168\u4e0d\u6703\u5c0d\u808c\u8089\u7d44\u7e54\u9178\u5316\u6709\u75bc\u75db\u53cd\u61c9\u3002\u8fa3\u6912\u7d20\u53d7\u9ad4\u86cb\u767d(TRPV1)\u662f\u53e6\u4e00\u500b\u91cd\u8981\u5206\u5b50\u3002\u7576TRPV1\u57fa\u56e0\u5254\u9664\u5f8c\uff0c\u808c\u8089\u7d44\u7e54\u9178\u5316\u4ecd\u6703\u8a98\u767c\u75bc\u75db\u904e\u654f\u5316\uff0c\u4f46\u50c5\u80fd\u6301\u7e8c\u5e7e\u500b\u5c0f\u6642\uff0c\u7121\u6cd5\u8a98\u767c\u6162\u6027\u75bc\u75db\u3002\u5728\u808c\u8089\u7d44\u7e54\u9178\u5316\u7684\u5be6\u9a57\uff0c\u5047\u5982\u540c\u6642\u4ee5\u85e5\u7269\u4f86\u6291\u5236ASIC3 (\u5982\uff1a\u6d77\u8475\u6bd2\u7d20APETx2)\u6216\u662fTRPV1(\u5982\uff1a\u8fa3\u6912\u5e73capsazepine)\uff0c\u4e94\u5929\u5f8c\u518d\u6b21\u7684\u808c\u8089\u9178\u5316\u523a\u6fc0\u5c31\u50c5\u80fd\u8a98\u767c\u77ed\u66ab\u7684\u75bc\u75db\u904e\u654f\u5316\u73fe\u8c61\uff0c\u800c\u7121\u6cd5\u8a98\u767c\u6162\u6027\u75bc\u75db\u3002\u4f46\u662f\uff0c\u5982\u679c\u518d\u6b21\u7684\u808c\u8089\u9178\u5316\u523a\u6fc0\u767c\u751f\u4e8e\u7b2c\u4e8c\u5929\uff0c\u4ecd\u6703\u8a98\u767c7~10\u5929\u7684\u75bc\u75db\u904e\u654f\u5316\u73fe\u8c61\u3002\u56e0\u6b64\uff0c\u6211\u5011\u53ef\u63a8\u8ad6\u51fa\uff0c\u7b2c\u4e00\u6b21\u808c\u8089\u7d44\u7e54\u9178\u5316\u4e0d\u50c5\u662f\u8a98\u767c\u4e86\u77ed\u66ab\u7684\u75bc\u75db\u904e\u654f\u5316\u73fe\u8c61\u3001\u4ea6\u8b93\u808c\u8089\u75db\u89ba\u795e\u7d93\u7522\u751f\u4e86\u53ef\u5851\u6027\u8b8a\u5316\u3002\u56e0\u6b64\uff0c\u4e94\u5929\u4ee5\u5167\u7684\u518d\u6b21\u808c\u8089\u9178\u5316\u523a\u6fc0\uff0c\u5c31\u8db3\u4ee5\u767c\u5c55\u6210\u6162\u6027\u75bc\u75db\u3002\u986f\u7136\uff0c\u523a\u6fc0ASIC3 \u8207TRPV1 \u90fd\u6703\u9020\u6210\u808c\u8089\u75db\u89ba\u795e\u7d93\u7684\u53ef\u5851\u6027\u8b8a\u5316\u3002 \u5728\u808c\u8089\u9178\u5316\u7684\u5be6\u9a57\u4e2d\uff0c\u82e5\u540c\u6642\u6291\u5236ASIC3 \u8207TRPV1 \u9019\u5169\u500b\u819c\u86cb\u767d\u5206\u5b50\uff0c\u5373\u53ef\u6291\u5236\u9178\u6240\u8a98\u767c\u7684\u75bc\u75db\u904e\u654f\u5316\u73fe\u8c61\u3002\u6709\u8da3\u7684\u662f\uff0c\u9019\u6a23\u7684\u5be6\u9a57\u5c0f\u9f20\u5c0d\u7b2c\u4e8c\u5929\u518d\u6b21\u7684\u808c\u8089\u9178\u5316\u523a\u6fc0\uff0c\u7adf\u5b8c\u5168\u6c92\u75bc\u75db\u53cd\u61c9\uff01\u6211\u5011\u53ef\u5f9e\u9019\u500b\u5be6\u9a57\u7d50\u679c\u5f97\u77e5\uff1a\u9664\u4e86ASIC3 \u8207TRPV1 \u4e4b\u5916\uff0c\u9084\u6709\u4e00\u500b\u672a\u77e5\u3001\u4f46\u662f\u5f88\u91cd\u8981\u7684\u9178\u654f\u6027\u53d7\u9ad4\u5206\u5b50\u53c3\u8207\u4e86\u808c\u8089\u9178\u5316\u904e\u7a0b\u4e2d\uff0c\u6162\u6027\u75bc\u75db\u7684\u8a98\u5c0e\u3002\u800c\u9019\u662f\u4e00\u500b\u53ef\u4ee5\u6b62\u75db\u7684\u9178\u654f\u6027\u53d7\u9ad4\u5206\u5b50\uff01<\/p>\n
\n\u5728\u9019\u500b\u7e96\u7dad\u808c\u75db\u75c7\u52d5\u7269\u6a21\u5f0f\u4e2d\u6240\u767c\u73fe\u7684\u201c\u9178\u6b62\u75db\u201d\u4f5c\u7528\u4f3c\u4e4e\u985b\u8986\u4e86\u5927\u5bb6\u50b3\u7d71\u5c0d\u201c\u75e0\u75db\u201d\u7684\u60f3\u6cd5\u3002\u6211\u5011\u9032\u4e00\u6b65\u767c\u73fe\uff0c\u201c\u9178\u6b62\u75db\u201d\u4f5c\u7528\u662f\u900f\u904e\u4e00\u7a2e\u53eb\u7269\u8ceaP (Substance P) \u7684\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\u4f86\u57f7\u884c\u3002\u7269\u8ceaP\u662f\u4e00\u7a2e\u5b58\u5728\u75db\u89ba\u795e\u7d93\u672b\u68a2\u7684\u91cd\u8981\u795e\u7d93\u50b3\u5c0e\u7269\u8cea\uff0c\u7576\u75db\u89ba\u795e\u7d93\u88ab\u523a\u6fc0\u5f8c\uff0c\u5728\u810a\u9ad3\u7aef\u7684\u795e\u7d93\u672b\u68a2\u6703\u91cb\u653e\u7269\u8ceaP\uff0c\u800c\u4fc3\u9032\u4e2d\u6a1e\u795e\u7d93\u7684\u81f4\u654f\u5316\uff0c\u4ee5\u8a98\u767c\u75bc\u75db\u3002\u7136\u800c\uff0c\u7269\u8ceaP\u5f9e\u808c\u8089\u7aef\u7684\u795e\u7d93\u672b\u68a2\u91cb\u653e\u5f8c\uff0c\u53ef\u6fc0\u6d3b\u75db\u89ba\u795e\u7d93\u4e0a\u7684\u9240\u96e2\u5b50\u901a\u9053\uff0c\u56e0\u800c\u6291\u5236\u795e\u7d93\u6d3b\u6027\uff0c\u4f86\u9054\u6210\u6b62\u75db\u4f5c\u7528\u3002\u7576\u808c\u8089\u9178\u5316\u6642\uff0c\u9178\u53ef\u6fc0\u6d3b\u4ff1\u6709ASIC3 \u6216TRPV1\u7684\u75db\u89ba\u795e\u7d93\uff0c\u9020\u6210\u75bc\u75db\u904e\u654f\u5316\u8207\u795e\u7d93\u53ef\u5851\u6027\u8b8a\u5316; \u540c\u6642\u4ea6\u6fc0\u6d3b\u4ff1\u6709\u201c\u9178\u6b62\u75db\u201d\u80fd\u529b\u7684\u795e\u7d93\u91cb\u653e\u7269\u8ceaP\uff0c\u4ee5\u6291\u5236\u75bc\u75db\uff08\u5716\u4e8c\uff09\u3002\u7269\u8ceaP\u5728\u808c\u8089\u4e2d\uff0c\u4f3c\u4e4e\u626e\u6f14\u8457\u715e\u8eca\u7684\u89d2\u8272\u3002\u7576\u808c\u8089\u9178\u5316\u767c\u751f\u6642\uff0c\u75bc\u75db\u8207\u6b62\u75db\u7684\u8a0a\u606f\u540c\u6642\u88ab\u555f\u52d5\uff0c\u56e0\u6b64\u5927\u90e8\u5206\u60c5\u6cc1\u4e0b\uff0c\u9178\u50c5\u6703\u8a98\u767c\u77ed\u66ab\u7684\u75bc\u75db\u904e\u654f\u5316\u73fe\u8c61; \u9700\u8981\u91cd\u8907\u7684\u808c\u8089\u9178\u5316\u523a\u6fc0\u75db\u89ba\u795e\u7d93\uff0c\u624d\u6703\u767c\u5c55\u70ba\u6162\u6027\u75bc\u75db\uff0c\u800c\u4e14\u9019\u6162\u6027\u75bc\u75db\u662f\u53ef\u63a7\u5236\u7684\uff0c\u6301\u7e8c\u7d04\u4e00\u500b\u6708\u6642\u9593\u3002\u7136\u800c\uff0c\u7576\u6211\u5011\u6291\u5236\u4e86\u7269\u8ceaP\u9019\u500b\u715e\u8eca\u7cfb\u7d71\uff0c\u4e00\u6b21\u808c\u8089\u7d44\u7e54\u9178\u5316\u7684\u523a\u6fc0\u5c31\u8db3\u4ee5\u8a98\u767c\u6162\u6027\u75bc\u75db\u3002\u800c\u4e14\uff0c\u9019\u6a23\u7684\u6162\u6027\u75bc\u75db\u6703\u8b8a\u5f97\u7121\u6cd5\u63a7\u5236\uff0c\u5be6\u9a57\u5c0f\u9f20\u6703\u4e00\u76f4\u75db\u4e0b\u53bb\u3002<\/p>\n
\n\u65e2\u7136\u9178\uff08\u6c2b\u96e2\u5b50\uff09\u53ef\u4ee5\u8a98\u767c\u75bc\u75db\u3001\u53c8\u53ef\u6b62\u75db\uff0c\u90a3\u9ebc\u81e8\u5e8a\u4e0a\uff0c\u75e0\u75db\u75c5\u4eba\u5230\u5e95\u662f\u62b1\u6028\u75e0\u9084\u662f\u75db\uff1f\u5728\u4e2d\u6587\u7684\u6982\u5ff5\uff0c\u75e0\u75db\u901a\u5e38\u662f\u88ab\u540c\u6642\u63d0\u8d77\u3002\u56e0\u6b64\uff0c\u75bc\u75db\u79d1\u91ab\u5e2b\u5728\u8655\u7406\u75c5\u4eba\u7684\u6162\u6027\u75bc\u75db\uff0c\u662f\u6c92\u6709\u5206\u5225\u75e0\u8207\u75db\u7684\u3002\u5728\u82f1\u6587\u7684\u66f8\u5beb\u4e2d\uff0c\u96d6\u7136\u6709soreness\u4ee3\u8868\u201c\u75e0\u201d\uff0c\u81e8\u5e8a\u4e0a\u4ea6\u662f\u7576\u6210pain (\u75db) \u4f86\u8655\u7406\u3002\u800c\u4e14\uff0c\u570b\u969b\u75bc\u75db\u7814\u7a76\u5354\u6703(International Association for the Study of Pain) \u6240\u5217\u8209\u7684\u75bc\u75db\u540d\u8a5e\u4e2d\uff0c\u4e26\u6c92\u6709soreness\u9019\u500b\u5b57\u3002\u7136\u800c\uff0c\u5f9e\u6211\u5011\u81ea\u8eab\u7684\u7d93\u9a57\u3001\u793e\u7fa4\u7684\u8a0e\u8ad6\u3001\u4ee5\u53ca\u81e8\u5e8a\u7684\u521d\u6b65\u89c0\u5bdf\uff0c\u4e5d\u6210\u4ee5\u4e0a\u7684\u570b\u4eba\u90fd\u53ef\u4ee5\u5f88\u6e05\u695a\u5730\u8aaa\u51fa\u75e0\u8207\u75db\u7684\u5dee\u5225\uff01\u6216\u8a31\uff0c\u5728\u83ef\u4eba\u6587\u5316\u4e2d\uff0c\u56e0\u70ba\u8a9e\u8a00\u8207\u6587\u5b57\u7684\u4f7f\u7528\u7fd2\u6163\uff0c\u6211\u5011\u6bd4\u8f03\u80fd\u5920\u7406\u89e3\u75e0\u8207\u75db\u7684\u5dee\u5225\u3002\u8a31\u591a\u9811\u6297\u578b\u7684\u6162\u6027\u75bc\u75db\uff0c\u6216\u8a31\u4e0d\u50c5\u6709\u75db\u7684\u6210\u5206\u3001\u9084\u6709\u75e0\u7684\u554f\u984c\u9700\u8981\u88ab\u7406\u89e3\u8207\u8655\u7406\u3002\u628a\u75e0\u8207\u75db\u7576\u6210\u5169\u7a2e\u4e0d\u540c\u6162\u6027\u75bc\u75db\u7684\u75c7\u72c0\uff0c\u672a\u4f86\u6216\u8a31\u6bd4\u8f03\u5bb9\u6613\u958b\u767c\u66f4\u5177\u5c08\u4e00\u6027\u7684\u6b62\u75db\u85e5\u7269\uff0c\u4ee5\u89e3\u6c7a\u6162\u6027\u75bc\u75db\u4e4b\u82e6\u3002<\/p>\n
\n\u75e0\u75db\u662f\u4e00\u500b\u91cd\u8981\u7684\u91ab\u5b78\u554f\u984c\uff0c\u6210\u56e0\u76f8\u7576\u8907\u96dc\u3002\u56e0\u70ba\u7d44\u7e54\u9178\u5316\u4e0d\u50c5\u80fd\u8a98\u767c\u75bc\u75db\uff0c\u4ea6\u53ef\u7522\u751f\u6b62\u75db\u8a0a\u606f\uff0c\u5b83\u8207\u75e0\u75db\u4e4b\u9593\u662f\u5426\u5b58\u5728\u8457\u56e0\u679c\u95dc\u4fc2\u4ecd\u672a\u6709\u5b9a\u8ad6\u3002\u672a\u4f86\u7684\u7814\u7a76\u65b9\u5411\u9700\u8981\u5c07\u75e0\u8207\u75db\u8996\u70ba\u5169\u7a2e\u4e0d\u540c\u7684\u81e8\u5e8a\u75c7\u72c0\uff0c\u4e26\u4e14\u63a2\u8a0e\u80cc\u5f8c\u7684\u5206\u5b50\u75c5\u7406\u6a5f\u5236\uff0c\u4ee5\u671f\u80fd\u555f\u767c\u4e26\u5e6b\u52a9\u65b0\u4e00\u4ee3\u6b62\u75db\u85e5\u7269\u7684\u958b\u767c\u3002<\/p>\n
\n1. Lin CCJ, Chen WN, Chen CJ, Lin YW, Zimmer A, Chen CC* (2012) An antinociceptive role for substance P in acid-induced chronic muscle pain. Proc Natl Acad Sci USA 109: E76-E83
\n2. Chen WN, Chen CC* (2014) Acid mediates a prolonged antinociception via substance P signaling in acid-induced chronic widespread pain. Mol Pain 10: 30
\n3. Sun WH, Chen CC* (2016) Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain. J Dent Res 95(2): 135-142.<\/p>\n![\"\"](\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/09\/1675-02-02.jpg\")
<\/p>\n![\"\"](\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2018\/09\/1675-02-01.jpg\")
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