\u73fe\u4ee3\u7684\u85e5\u7269\u7814\u767c\u6d41\u7a0b\uff0c\u53ef\u7c21\u8981\u5730\u6558\u8ff0\u70ba\u4ee5\u4e0b\u6b65\u9a5f\uff1a1. \u5148\u900f\u904e\u5927\u898f\u6a21\u57fa\u56e0\u9ad4\u5b78\u3001\u8207\u86cb\u767d\u8cea\u9ad4\u5b78\u5be6\u9a57\uff0c\u627e\u5230\u53ef\u6210\u70ba\u85e5\u7269\u7684\u5206\u5b50\u53ca\u6cbb\u7642\u6a19\u9776 \u2192 2. \u89e3\u51fa\u5176\u5206\u5b50\u7d50\u69cb \u2192 3. \u4f9d\u6b64\u5206\u5b50\u7d50\u69cb\u4f86\u8a2d\u8a08\u5408\u6210\u85e5\u7269\u5316\u5408\u7269\u3002\u96d6\u7136\u9019\u904e\u7a0b\u5e7e\u884c\u5b57\u5c31\u6253\u5b8c\uff0c\u4f46\u4e0d\u50c5\u9700\u8981\u751f\u7269\u91ab\u5b78\u3001\u85e5\u7406\u5b78\u3001\u751f\u7269\u5316\u5b78\u3001\u85e5\u7269\u5316\u5b78\u7b49\u8de8\u9818\u57df\u5718\u968a\u6295\u5165\u7814\u7a76\uff0c\u4e5f\u8017\u8cbb\u8d85\u4e4e\u60f3\u50cf\u7684\u91d1\u9322\u8207\u6642\u9593\u3002<\/p>\n
\u4e00\u7a2e\u85e5\u7269\uff0c\u5f9e\u5be6\u9a57\u5ba4\u7814\u767c\u3001\u81e8\u5e8a\u8a66\u9a57\u3001\u723e\u5f8c\u4e0a\u5e02\u7684\u6642\u7a0b\u5341\u5206\u6f2b\u9577\uff0c\u653f\u5e9c\u8207\u79d1\u5b78\u5bb6\u5011\u7686\u5728\u601d\u8003\u5982\u4f55\u52a0\u901f\u6b64\u6d41\u7a0b\uff0c\u6e1b\u5c11\u7814\u767c\u8cc7\u6e90\u7684\u932f\u7f6e\uff0c\u4e26\u5354\u52a9\u66f4\u591a\u6c11\u773e\u7de9\u65bc\u82e6\u75db\u3002<\/p>\n<\/div>\n<\/div>\n
\n\u6211\u5011\u4f7f\u7528\u7684\u85e5\u7269\u4e4b\u6240\u4ee5\u6709\u85e5\u6548\uff0c\u662f\u56e0\u70ba\u85e5\u7269\u5206\u5b50\u8207\u9ad4\u5167\u7684\u6a19\u9776\u5206\u5b50(\u5927\u591a\u662f\u86cb\u767d\u8cea)\uff0c\u7522\u751f\u4ea4\u4e92\u4f5c\u7528\u6240\u81f4\u3002<\/strong><\/h4>\n<\/blockquote>\n<\/div>\n
\n\n\u4ee5\u5f80\u4e3b\u8981\u662f\u900f\u904e\u751f\u7269\u5316\u5b78\u5be6\u9a57\u3001\u6216\u751f\u7269\u7269\u7406\u5be6\u9a57\u4f86\u4e86\u89e3\u6b64\u4ea4\u4e92\u4f5c\u7528\uff0c\u4f46\u662f\u9019\u4e9b\u5be6\u9a57\u65b9\u5f0f\uff0c\u4e26\u4e0d\u80fd\u63d0\u4f9b\u300c\u85e5\u7269\u5206\u5b50\u300d\u8207\u5176\u4f5c\u7528\u7684\u300c\u6a19\u9776\u751f\u7269\u5206\u5b50\u300d\u4e4b\u9593\u4f5c\u7528\u7684\u52d5\u614b\u95dc\u4fc2\uff0c\u800c\u4e14\u5927\u90e8\u5206\u7684\u5be6\u9a57\u65b9\u6cd5\uff0c\u7121\u6cd5\u63d0\u4f9b\u539f\u5b50\u5c3a\u5ea6\u7684\u8cc7\u8a0a\uff0c\u56e0\u6b64\u5c0d\u85e5\u7269\u8a2d\u8a08\u7684\u76f4\u63a5\u7528\u8655\u6709\u9650\u3002\u8981\u77e5\u9053\uff0c\u8a31\u591a\u85e5\u7269\u5206\u5b50\u53ea\u8981\u5dee\u4e86\u4e00\u500b\u539f\u5b50\uff0c\u5176\u85e5\u6548\u5c31\u6709\u53ef\u80fd\u622a\u7136\u4e0d\u540c\u3002\u6b64\u5916\uff0c\u9019\u4e9b\u85e5\u7269\u958b\u767c\u9700\u8981\u7684\u5be6\u9a57\u6240\u8cbb\u4e0d\u8cb2\uff0c\u4e00\u500b\u932f\u8aa4\u7684\u6c7a\u7b56\uff0c\u4fbf\u6703\u5c0e\u81f4\u7814\u7a76\u9032\u5ea6\u7684\u63a8\u9072\u8207\u7814\u7a76\u8cc7\u6e90\u7684\u8017\u640d\u3002<\/p>\n
\u6709\u9451\u65bc\u6b64\uff0c\u6797\u69ae\u4fe1\u5718\u968a\u7684\u8457\u773c\u9ede\u70ba\uff1a\u5982\u679c\u80fd\u5920\u5728\u85e5\u7269\u7814\u767c\u521d\u671f\uff0c\u5148\u5229\u7528\u96fb\u8166\u6a21\u64ec\u85e5\u7269\u958b\u767c\u6240\u9078\u5b9a\u7684\u300c\u6a19\u9776\u5206\u5b50\u300d\uff0c\u4f86\u5feb\u901f\u7be9\u9078\u51fa\u6709\u6a5f\u6703\u7684\u300c\u5019\u9078\u85e5\u7269\u5206\u5b50\u300d\uff0c\u9ad8\u7cbe\u5ea6\u8a08\u7b97\u5169\u8005\u76f8\u9047\u5f8c\u6703\u5982\u4f55\u4f5c\u7528\u8207\u904b\u52d5\uff0c\u5c31\u80fd\u5f88\u5927\u7a0b\u5ea6\u5730\u5354\u52a9\u5be6\u9a57\u5718\u968a\u5c11\u8d70\u51a4\u6789\u8def\uff0c\u6e1b\u5c11\u85e5\u7269\u958b\u767c\u5931\u6557\u8017\u640d\u7684\u4eba\u529b\u3001\u7269\u529b\u8207\u5149\u9670\u3002<\/p>\n
\u8981\u9054\u5230\u9019\u500b\u76ee\u6a19\uff0c\u4e0d\u50c5\u6709\u8cf4\u96fb\u8166\u9010\u5e74\u9032\u6b65\u7684\u9ad8\u901f\u904b\u7b97\u80fd\u529b\uff0c\u4ee5\u53ca\u8a08\u7b97\u7269\u7406\u3001\u5316\u5b78\u754c\u5c0d\u8a08\u7b97\u65b9\u6cd5\u7684\u7cbe\u9032\uff0c\u4e5f\u6709\u8cf4\u79d1\u5b78\u5bb6\u5c0d\u65bc\u751f\u7269\u5206\u5b50\u7d50\u69cb\u7684\u4e86\u89e3\u3002<\/p>\n
\u672c\u6587\u5c08\u8a2a\u6797\u69ae\u4fe1\uff0c\u5f9e\u7269\u7406\u51fa\u8eab\uff0c\u8de8\u8db3\u8a08\u7b97\u6a5f\u79d1\u5b78\u8207\u5206\u5b50\u52d5\u529b\u5b78\uff0c\u73fe\u5c07\u5c08\u696d\u904b\u7528\u65bc\u85e5\u7269\u8a2d\u8a08\u3002
\n\u651d\u5f71\u2502\u5f35\u8a9e\u8fb0<\/p>\n\u85e5\u7269\u8a2d\u8a08\uff0c\u6700\u91cd\u8981\u7684\u89c0\u5ff5\u662f\uff1f<\/b><\/h2>\n
\n\u85e5\u7269\u8a2d\u8a08\u4e0d\u80fd\u53ea\u505c\u7559\u5728\u300c\u7d50\u69cb\u300d\u5c64\u6b21\uff0c\u4e5f\u9700\u628a\u86cb\u767d\u8cea\u7684\u300c\u52d5\u614b\u300d\u8003\u616e\u9032\u53bb\u3002<\/strong><\/h4>\n<\/blockquote>\n
\u8981\u6a21\u64ec\u85e5\u7269\u5728\u539f\u5b50\u3001\u5206\u5b50\u5c64\u6b21\u7684\u85e5\u7406\u4f5c\u7528\u53cd\u61c9\uff0c\u9700\u5148\u5f97\u5230\u6703\u548c\u85e5\u7269\u5206\u5b50\u4f5c\u7528\u7684\u9ad4\u5167\u86cb\u767d\u8cea\u5206\u5b50\u3001\u6216\u5176\u4ed6\u751f\u7269\u5206\u5b50\u7684\u7d50\u69cb\u3002<\/p>\n
\u96d6\u7136\u6709\u86cb\u767d\u8cea\u7d50\u69cb\u8cc7\u6599\u5eab (Protein Data Bank<\/a>) \u63d0\u4f9b\u4e86\u8a31\u591a\u5229\u7528 X-ray \u7d50\u6676\u5b78\u3001\u6838\u78c1\u5171\u632f\u5b78\u3001\u4f4e\u6eab\u96fb\u5b50\u986f\u5fae\u8853\u6240\u6c7a\u5b9a\u51fa\u4f86\u7684\u9ad8\u89e3\u6790\u5ea6\u5206\u5b50\u7d50\u69cb\uff0c\u4f46\u8a72\u8cc7\u6599\u5eab\u88e1\u7684\u5206\u5b50\u7d50\u69cb\u5be6\u8cea\u4e0a\u4ecd\u53ea\u662f\u6a21\u578b\u3002\u8209\u4f8b\u4f86\u8aaa\uff0c\u4e0d\u53ef\u80fd\u5206\u5b50\u88e1\u9762\u6bcf\u500b\u539f\u5b50\u7684 X, Y, Z \u4f4d\u7f6e\u90fd\u771f\u7684\u56fa\u5b9a\u5728\u90a3\u88e1\uff0c\u6211\u5011\u77e5\u9053\u4e00\u822c\u5be6\u9a57\u689d\u4ef6\u4e2d\uff0c\u86cb\u767d\u8cea\u662f\u76f8\u7576\u52d5\u614b\u7684\u3002\u56e0\u6b64\uff0c\u9019\u9700\u8981\u6709\u7d50\u69cb\u751f\u7269\u5b78\u7684\u77e5\u8b58\uff0c\u4f86\u7406\u89e3\u86cb\u767d\u8cea\u7d50\u69cb\u8cc7\u6599\u5eab\u4e2d\u300c\u5206\u5b50\u7d50\u69cb\u300d\u7684\u771f\u5be6\u610f\u7fa9\u3002<\/p>\n
\n\u8afe\u8c9d\u723e\u734e\u5f97\u4e3b\u514b\u91cc\u514b (Francis Crick, 1916~2004) \u6709\u4e00\u53e5\u540d\u8a00\uff1a\u300c\u5982\u679c\u4f60\u8981\u4e86\u89e3\u529f\u80fd\uff0c\u4f60\u8981\u7814\u7a76\u7d50\u69cb\u300d\u3002\u9019\u908a\u6240\u8b02\u7684\u529f\u80fd\uff0c\u662f\u6307\u751f\u7269\u5206\u5b50\u7684\u529f\u80fd\u3002
\n\u5716\u7247\u4f86\u6e90\u2502Wikipedia<\/a>\u00a0\u8cc7\u6599\u4f86\u6e90\u2502\u3008\u6311\u6230\u795e\u5947\u5b50\u5f48\u2014\u9ad8\u6548\u80fd\u8a08\u7b97\u8207\u85e5\u7269\u8a2d\u8a08\u3009\uff0c\u4f5c\u8005\uff1a\u6797\u69ae\u4fe1<\/a><\/p>\n\u6211\u5011\u505a\u85e5\u7269\u8a2d\u8a08\uff0c\u76f8\u7576\u9700\u8981\u548c\u7d50\u69cb\u751f\u7269\u5b78\u7684\u5718\u968a\u5408\u4f5c\u3002\u6211\u5011\u4ee5\u5206\u5b50\u52d5\u529b\u5b78<\/a>\u00a0(molecular dynamics) \u6a21\u64ec\u51fa\u4f86\u7684\u86cb\u767d\u8cea\u52d5\u614b\u8cc7\u8a0a\uff0c\u9700\u8981\u900f\u904e\u9032\u968e\u7684\u751f\u7269\u7269\u7406\u5be6\u9a57\uff0c\u9593\u63a5\u9a57\u8b49\u6240\u5f97\u5230\u7684\u52d5\u614b\u8a0a\u606f\uff0c\u4f8b\u5982\uff1a\u5e36\u6709\u6642\u9593\u89e3\u6790\u5ea6\u7684\u00a0X \u5c04\u7dda\u6676\u9ad4\u5b78<\/a>\u3001\u751a\u81f3\u662f\u81ea\u7531\u96fb\u5b50\u96f7\u5c04<\/a>\u3002\u4e0d\u904e\uff0c\u9019\u4e9b\u5be6\u9a57\u6280\u8853\u96d6\u6301\u7e8c\u6709\u9032\u5c55\uff0c\u4ecd\u7136\u9032\u5c55\u5f97\u5341\u5206\u7de9\u6162\u3002<\/p>\n
\u5b78\u8853\u7814\u7a76\u6709\u8da3\u7684\u73fe\u8c61\u662f\uff0c\u5b78\u8853\u754c\u50cf\u500b\u5f88\u5927\u7684\u751f\u614b\u74b0\u5883\uff0c\u6709\u4e9b\u4eba\u6703\u9032\u4f86\u3001\u6709\u4e9b\u4eba\u6703\u51fa\u53bb\uff1b\u9032\u4f86\u7684\u6642\u9593\u9ede\u4e0d\u540c\uff0c\u770b\u5230\u7684\u4e16\u754c\u4e5f\u5f88\u4e0d\u540c\uff1b\u800c\u6bcf\u500b\u4eba\u7372\u5f97\u8207\u63d0\u4f9b\u7684\u8cc7\u8a0a\u90fd\u4e0d\u592a\u4e00\u6a23\uff0c\u6bcf\u6b21\u9032\u4f86\u7684\u4eba\u90fd\u6703\u7559\u4e0b\u4e0d\u540c\u7a0b\u5ea6\u7684\u9032\u5c55\u3002\u50cf\u9019\u6a23\u9010\u6b65\u63a8\u9032\uff0c\u5f9e\u6b77\u53f2\u4f86\u770b\uff0c\u901a\u5e38\u8981\u7528\u4e8c\u3001\u4e09\u5341\u5e74\u6216\u4ee5\u4e0a\u7684\u6642\u9593\u5c3a\u5ea6\uff0c\u624d\u6bd4\u8f03\u770b\u5f97\u51fa\u5f88\u7a81\u7834\u6027\u7684\u7814\u7a76\u9032\u6b65\u3002<\/p>\n
\u76ee\u524d\u5be6\u9a57\u5ba4\u7684\u7814\u7a76\u65b9\u5411\uff1f<\/b><\/h2>\n
\n\n\u85e5\u7269\u5206\u5b50\u5982\u4f55\u8207\u9ad4\u5167\u7684\u751f\u7269\u5206\u5b50\u7d50\u5408\u3001\u4ea4\u4e92\u4f5c\u7528\uff0c\u662f\u6211\u5011\u7814\u7a76\u7684\u6838\u5fc3\u4e3b\u984c\u3002<\/strong><\/h4>\n<\/blockquote>\n<\/div>\n
\n\n\u4f8b\u5982\uff0c\u82e5\u8981\u958b\u767c\u5929\u7136\u7269 (Natural product<\/a>) \u88fd\u6210\u73fe\u4ee3\u897f\u65b9\u91ab\u5b78\u7684\u85e5\u7269\uff0c\u904e\u5f80\u8981\u5f9e\u53e4\u7c4d\u6216\u6587\u737b\u53bb\u770b\u67d0\u7a2e\u8349\u85e5\u6216\u8907\u65b9\u6709\u4ec0\u9ebc\u53ef\u80fd\u7684\u6d3b\u6027\uff0c\u63a5\u8457\u8403\u53d6\u3001\u7d14\u5316\u51fa\u6709\u6548\u5316\u5408\u7269\u4e4b\u5f8c\uff0c\u8981\u518d\u900f\u904e\u751f\u5316\u5be6\u9a57\u6e2c\u8a66\u5176\u751f\u7269\u6d3b\u6027\uff0c\u9019\u662f\u4e00\u500b\u5f88\u6f2b\u9577\u7684\u6e2c\u8a66\u904e\u7a0b\uff0c\u671f\u9593\u4e5f\u9700\u8981\u5f88\u591a\u7684\u63a8\u6e2c\u3002<\/p>\n
\u9019\u5e7e\u5e74\u4f86\uff0c\u6211\u5011\u767c\u5c55\u51fa\u8a08\u7b97\u85e5\u7269\u5206\u5b50\u548c\u4e0d\u540c\u86cb\u767d\u8cea\u7cfb\u7d71\u53cd\u61c9\u7684\u7a0b\u5f0f\uff0c\u4e26\u5efa\u69cb\u6210\u00a0idTarget\u00a0<\/a>\u300c\u85e5\u7269\u6a19\u9776\u9810\u6e2c\u5e73\u53f0\u300d\uff0c\u958b\u653e\u7d66\u5927\u5bb6\u904b\u7528\uff0c\u65b9\u4fbf\u5176\u4ed6\u7814\u7a76\u4eba\u54e1\u63a2\u7d22\u85e5\u7269\u53ef\u80fd\u7684\u4f5c\u7528\u6a19\u9776\u3002<\/p>\n
\u6211\u5011\u7684\u60f3\u6cd5\u662f\uff0c\u8981\u591a\u591a\u91cd\u8996\u3001\u904b\u7528\u7d50\u69cb\u751f\u7269\u5b78\u8fd1\u4e8c\u5341\u5e74\u7684\u5927\u91cf\u7d50\u69cb\u8cc7\u6599\uff0c\u914d\u5408\u85e5\u7269\u5206\u5b50\u548c\u86cb\u767d\u8cea\u7d50\u5408\u7684\u81ea\u7531\u80fd\u8a08\u7b97<\/a>\uff0c\u5148\u627e\u51fa\u85e5\u7269\u5206\u5b50\u548c\u90a3\u4e9b\u86cb\u767d\u8cea\u8f03\u6709\u53ef\u80fd\u4f5c\u7528\u3002\u6211\u5011\u77e5\u9053\uff0c\u5316\u5b78\u4e0a\u4e00\u500b\u53cd\u61c9\u6703\u4e0d\u6703\u767c\u751f\u3001\u6216\u591a\u5bb9\u6613\u767c\u751f\uff0c\u53ef\u4ee5\u7531\u81ea\u7531\u80fd\u4f86\u9810\u6e2c\u3002\u56e0\u6b64\uff0c\u751f\u7269\u7cfb\u7d71\u4e0a\u5feb\u901f\u3001\u6e96\u78ba\u7684\u81ea\u7531\u80fd\u8a08\u7b97\uff0c\u4e00\u76f4\u662f\u6211\u5011\u5be6\u9a57\u5ba4\u7684\u6838\u5fc3\u57fa\u790e\u8ab2\u984c\u3002\u6211\u5011\u6700\u8fd1\u4e5f\u904b\u7528\u6df1\u5ea6\u5b78\u7fd2<\/a>\uff0c\u4f86\u958b\u767c\u81ea\u7531\u80fd\u8a08\u7b97\u7684\u65b9\u6cd5\u3002<\/p>\n
\n\u6797\u69ae\u4fe1\u5718\u968a\u5efa\u7acb\u7684\u300c\u85e5\u7269\u6a19\u9776\u9810\u6e2c\u5e73\u53f0\u300d idTarget \uff0c\u53ea\u8981\u4e0a\u50b3\u85e5\u7269\u5206\u5b50\u7d50\u69cb\u5716\uff0c\u4fbf\u80fd\u9810\u6e2c\u86cb\u767d\u8cea\u8cc7\u6599\u5eab (Protein Data Bank) \u5176\u4e2d\u53ef\u80fd\u7d50\u5408\u7684\u6a19\u9776\u86cb\u767d\u8cea\u5206\u5b50\u3002
\n\u8cc7\u6599\u4f86\u6e90\u2502idTarget<\/a><\/p>\n\u6211\u5011\u5be6\u9a57\u5ba4\u53e6\u4e00\u500b\u91cd\u9ede\uff0c\u662f\u5c07\u50b3\u7d71\u5e38\u898b\u7684\u85e5\u6750\u4ee5\u79d1\u5b78\u65b9\u6cd5\u518d\u7814\u7a76\uff0c\u9019\u4e5f\u662f\u76ee\u524d\u91ab\u85e5\u7814\u7a76\u7684\u91cd\u8981\u65b9\u5411\u4e4b\u4e00\u3002<\/p>\n
\u4f8b\u5982\uff0c\u672c\u8349\u7db1\u76ee\u8a18\u8f09\u300c\u5929\u9ebb<\/a>\u300d\u5177\u6709\u5b89\u795e\u8207\u93ae\u5b9a\u7684\u6548\u679c\uff0c\u800c\u73fe\u8077\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u7684\u6797\u96f2\u84ee<\/a>\u6559\u6388\u5718\u968a\u767c\u73fe\uff0c\u5929\u9ebb\u4e2d\u6709\u500b\u53eb\u4f5c T1-11 \u7684\u65b0\u7684\u5206\u5b50\uff0c\u8207\u904e\u53bb\u8f03\u719f\u77e5\u7684\u5929\u9ebb\u7d20\u6709\u5f88\u4e0d\u540c\u7684\u4f5c\u7528\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u4e2d\u7814\u9662\u751f\u7269\u91ab\u5b78\u7814\u7a76\u6240\u7684\u9673\u5100\u838a<\/a>\u535a\u58eb\u5718\u968a\u5247\u767c\u73fe\uff0c T1-11 \u5206\u5b50\u80fd\u7528\u65bc\u6cbb\u7642\u4ea8\u4e01\u9813\u821e\u8e48\u75c7\u3002\u57fa\u65bc\u9019\u4e9b\u7814\u7a76\u767c\u73fe\uff0c\u6211\u5011\u5be6\u9a57\u5ba4\u900f\u904e\u96fb\u8166\u8a2d\u8a08\u9069\u5408\u7684\u85e5\u7269\u5206\u5b50\uff0c\u4e26\u7531\u53f0\u5927\u5316\u5b78\u7cfb\u7684\u65b9\u4fca\u6c11<\/a>\u6559\u6388\u5718\u968a\u5c07\u85e5\u7269\u5408\u6210\u51fa\u4f86\u3002\u9019\u5c31\u662f\u4e00\u7a2e\u65b0\u85e5\u958b\u767c\u7684\u8de8\u9818\u57df\u5408\u4f5c\u65b9\u5f0f\u3002<\/p>\n
\u60a8\u4ee5\u524d\u8b80\u7269\u7406\uff0c\u600e\u9ebc\u6703\u8de8\u9818\u57df\u81f3\u85e5\u7269\u8a2d\u8a08\uff1f<\/b><\/h2>\n