◆◇學術研討會◇◆

  國際醣類分子免疫學學術研討會暨台加醣生物學學術交流會

International Symposium	on Molecular Immunology	of Complex 
Carbohydrates-II, and Taiwan-Canada Glycobiology Workshop

			      Program

	Saturday, August 28, 1999

	Registration, and Reception:

	4:00P.M. to 8:30 P.M.

	Activity Center, 2nd Floor, Academia Sinica

	Poster:	6:30 P.M. to 9:00 P.M.

	Meeting	Place: 1st Floor, Institute of Biological 
		       Chemistry, Academia Sinica

	Sunday,	August 29, 1999

	Registration & Service Desk:

	8:20A.M. to 5:00 P.M.

	Meeting	Place: Auditorium, 1st Floor, Institute	of 
		       Biological Chemistry, Academia Sinica

	8:30 A.M. pening Remarks

		  -A. ANTIBODY SPECIFICITY, GLYCOTOPES AND 
		  LECTINOLOGY

		  hair:	Winifred M Watkins

	8:35 A.M. The Structural Basis for Carbohydrate	
		  Recognition by Lectins

		  Nathan Sharon

	9:20 A.M. Pathogen-host	Protein-Carbohydrate 
		  Interactions as the Basis of Important 
		  Infections

		  Karl-Anders Karlsson

		  I-B. ANTIBODY	SPECIFICITY, GLYCOTOPES	AND 
		  LECTINOLOGY

		  Chair: Karl-Anders Karlsson

	10:20 A.M.Animal Lectins: from Initial Description to 
		  Elaborate Structural and Functional
		  Classification

		  Herbert Kaltner and Hans-Joachim Gabius

	10:50 A.M The Aplysia Gonad Lectin (AGL)

		  Nechama-Gilboa Garber

	11:20 A.M.Lectin as a Gene Delivery Vector

		  Pi-Wan Cheng

	11:50 A.M.Analysis of a	Murine Anti-Ganglioside	GD2

		  Monoclonal Antibody Expressing both IgG2a and	
		  IgG3

		  Isotypes: Monoclonality,Apoptosis Triggering,	
		  and Activation of Cellular Cytotoxicity of
		  Melanoma

		  Chien-Cheng Lin, Yung-Chi Shen, Cheng-Keng 
		  Chuang, and Shuen-Kuei Liao

	12:05 P.M.Interaction of Human Alkaline	Phosphatase 
		  Isoenzyme with Soybean Lectin

		  J. S.	Wei

		  II-A.GLYCOTOPES, GLYCOSYLATION AND ANTIGEN 
		  SYNTHESIS AND	DEGRADATION

		  Chair: Jim Richard and Kay-Hooi Khoo

	1:30 P.M. Regulation of	Expression of Carbohydrate 
		  Ligands for Cell Adhesion Molecules in the
		  Selectin Family

		  Reiji	Kannagi

	2:10 P.M. Interaction of GM2 Activator Protein with 
		  Glycosphingolipids

		  Su-Chen Li, Yu-Teh Li	and Yoichiro Hama

		  V-A.GLYCOFORM	ANALYSIS: GLYCAN DETECTION, 
		  BINDING PROPERTIES OF	COMPLEX	CARBOHYDRATES, 
		  COMBINING SITES OF LECTINS AND STRUCTURE 
		  ANALYSIS

	2:50 P.M. Topological Recognition of Proteins by 
		  Engineered Glycoligands

		  Shin-Ichiro Nishimura	and Noriko Nagahori

	3:20 P.M. Poster Session and Discussion

	Monday,	August 30, 1999

		  II-B.GLYCOTOPES, GLYCOSYLATION AND ANTIGEN 
		  SYNTHESIS AND	DEGRADATION

		  Chair: Nathan	Sharon

	8:40 A.M. Fucosyl- and Sialyl-transferase Genes	
		  Involved in the Regulation of	Sialyl-Lex 
		  Expression

		  in Differentiating Myeloid Cells

		  Winifred Watkins and Julia L.Clarke

	9:30 A.M. Tumor-associated Carbohydrate	Antigens 
		  Defining Malignancy, and Development of Anti-
		  cancer Vaccines

		  Sen-itiroh Hakomori

		  II-C.GLYCOTOPES, GLYCOSYLATION AND ANTIGEN 
		  SYNTHESIS AND	DEGRADATION

		  Chair: Robert	Yu

	10:30 A.M.Some Recent Studies on the Biosynthesis of 
		  Ganglioside Antigens in the Nervous System

		  Robert K. Yu

	11:10 A.M.Structure and	Functional Genomics of 
		  Lipopolysaccharide Expression	in 
		  Haemophilus

		  Influenzae

		  J.C.Richards

	11:50 A.M.Structure and	Biosynthesis of	Snail Galactans	
		  Hagen	Bretting

		  II-C.GLYCOTOPES, GLYCOSYLATION AND ANTIGEN 
		  SYNTHESIS AND	DEGRADATION

		  Chair: Pi-Wan	Cheng and Su-Chen Li

	1:30 P.M. Protective Immunity and Gene Expression 
		  Related to Pneumococcal Glycoconjugates

		  Chi-Jen Lee, and Zhong-Ming Li

	2:10 P.M. Modification of Tumor-associated Antigens by 
		  Introduction of a cDNA Encoding a Mucin

		  Core 2-L Enzyme

		  Pi-Wan Cheng

	2:50 P.M. GPI-linked Glycolipids of Leishmania:	
		  Structure and	Pathology

		  Kuo-Yuan Hwa

	3:20 P.M. Molecular Cloning and	Expression of a	Novel 
		  b1, 6-N-Acetylglucosaminyltransferase	that

		  Forms	Core 2,	Core 4 and I Branches.

		  Jiunn-Chern Yeh, Edgar Ong, and Minoru Fukuda

	3:50 P.M. Mistletoe Lectins: Glycosylation Pattern and 
		  Biological Activities

		  Uwe Pfuller

	4:05 P.M. Poster Session and Discussion

	Tuesday, August	31, 1999

		   III-A. COMPLEX CARBOHYDRATES	AS ANTIGENS

		   Chair: Hans Vliegenthart

	8:20 A.M.  Metabolism and Role of O-Acetylated Sialic 
		   Acids Roland	Schauer

	9:00 A.M.  Carbohydrate-Protein	Interactions

		   Hans	Vliegenthart

	9:40 A.M.  Red Blood Cell Antigens Responsible for 
		   Inherited Types of Polyagglutination

		   Elwira Lisowska

		   III-B. COMPLEX CARBOHYDRATES	AS ANTIGENS

		   Chair: Roland Schauer

		   for Hereditary Polyagglutinations

	10:40 A.M. Molecular Mimicry of	Host Structures	by 
		   Lipooligosaccharides	of Neisseria 
		   Meningitidis:

		   Characterization of Sialylated and 
		   Nonsialylated Lacto-N-neotetraose Sequences
		   in Lipooligosaccharides Using Monoclonal 
		   Antibodies and Specific Lectins

		   Chao-Ming Tsai

	11:10 A.M. KDN-containing Glycoprotein from Loach Skin 
		   Mucus

		   Hiroki Nakagawa and Yu-Teh Li

	Wednesday, September 1,	1999

		   IV. GLYCANS AS ANTI-INFECTIVE DRUGS,	AS 
		   CANCER/OR TUMOR

		   ANTIGENS AND	AS VACCINE

		   Chair: Elwira Lisowska

	8:40 A.M.  Synthesis of	Complex	Carbohydrates and 
		   Glycoconjugates: From Anti-bacterial	
		   Vaccines to Anti-cancer Therapeutics

		   Wei Zou

	9:20 A.M.  Can Sulfatide Induce	Thrombotic Dieases 
		   Associated with Cancer?

		   Mamoru Kyogashima

		   V-B.GLYCOFORM ANALYSIS: GLYCAN DETECTION, 
		   BINDING PROPERTIES OF COMPLEX CARBOHYDRATES,	
		   COMBINING SITES OF LECTINS AND STRUCTURE 
		   ANALYSIS

		   Chair: Chi-Jen Lee

	9:50 A.M.  NMR and Molecular Modeling of Complex 
		   Carbohydrates and Carbohydrate-Protein
		   Interactions. Application to	Anti-bacterial 
		   Vaccines

		   Jean	Rober Brisson

	10:30 A.M. Mass	Spectrometric and Electrophoretic 
		   Approaches to the Characterization of 
		   Heterogenous	Surface	Lipopolysaccharides 
		   form	Pathogenic Bacteria

		   Pierre Thibault