{"id":9753,"date":"2022-06-16T00:06:21","date_gmt":"2022-06-15T16:06:21","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=9753"},"modified":"2024-03-13T09:19:04","modified_gmt":"2024-03-13T01:19:04","slug":"pdac-tumor-cell-fibroblast-interactions-promote-metastasis-via-homophilic-atp1a1-binding","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/9753\/","title":{"rendered":"PDAC tumor cell-fibroblast interactions promote metastasis via Homophilic ATP1A1 Binding"},"content":{"rendered":"<p>A research team led by Dr. Wen-Hwa Lee and Dr. Chun-Mei Hu from the Genomics Research Center revealed how PDAC tumor cells recruit nearby cells, called fibroblasts, to work as their helpers at tumor-stromal boundaries through direct tumor-fibroblast interaction. These interactions in PDAC progression enhance cancer cell migration and make the tumors more malignant. Blockage of direct contact between tumor cells and fibroblasts may represent a promising therapeutic strategy for patients with PDAC. This research was published in Nature Communications in May 2022.<\/p>\n<p>Article\u3000Link: <a href=\"https:\/\/doi.org\/10.1038\/s41467-022-30638-4\">https:\/\/doi.org\/10.1038\/s41467-022-30638-4 <\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-27324 aligncenter\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/06\/1\u6f2b\u6b65\u79d1\u7814_\u57fa\u56e0\u9ad4\u80e1\u6625\u7f8e\u674e\u6587\u83ef.png\" alt=\"PDAC tumor cell-fibroblast interactions promote metastasis via Homophilic ATP1A1 Binding\" width=\"836\" height=\"504\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team led by Dr. Wen-Hwa Lee and Dr. Chun-Mei Hu from the Genomics Research Center revealed how PDAC tumor cells recruit nearby cells, called fibroblasts, to work as their helpers at tumor-stromal boundaries through direct tumor-fibroblast interaction. These interactions in PDAC progression enhance cancer cell migration and make the tumors more malignant. Blockage [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9795,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9753"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=9753"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9753\/revisions"}],"predecessor-version":[{"id":13188,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9753\/revisions\/13188"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/9795"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=9753"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=9753"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=9753"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}