Institute of Biomedical Sciences assistant research fellow Dr. Kurt Yun Mou\u2019s team developed a novel cancer therapy and published their results in \u201cMolecular Therapy\u201d in April this year. The research group develop a Trojan Horse approach to target TNF-\u03b1 for cancer therapy. They employed phage\/yeast display to select non-neutralizing antibodies that can piggyback on TNF-\u03b1 and co-internalize into cells. The antibody conjugated with toxins killed cancer cells in a TNF-\u03b1-dependent manner. Intratumoral injection of engineered E. coli<\/em> secreting the immunotoxin greatly inhibited the tumor growth in mice and enhanced the anti-tumor tumor-infiltrating immune cells, including N1 neutrophils, M1 macrophages, and activated CD4+ and CD8+ lymphocytes. The results were published in Molecular Therapy<\/em>.<\/p>\n

Article Link: https:\/\/www.cell.com\/molecular-therapy-family\/molecular-therapy\/fulltext\/S1525-0016(22)00237-4<\/a><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Institute of Biomedical Sciences assistant research fellow Dr. Kurt Yun Mou\u2019s team developed a novel cancer therapy and published their results in \u201cMolecular Therapy\u201d in April this year. The research group develop a Trojan Horse approach to target TNF-\u03b1 for cancer therapy. They employed phage\/yeast display to select non-neutralizing antibodies that can piggyback on TNF-\u03b1 […]<\/p>\n","protected":false},"author":1,"featured_media":9672,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9671"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=9671"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9671\/revisions"}],"predecessor-version":[{"id":13197,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9671\/revisions\/13197"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/9672"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=9671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=9671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=9671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}