{"id":9671,"date":"2022-05-19T00:17:04","date_gmt":"2022-05-18T16:17:04","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=9671"},"modified":"2024-03-13T09:19:57","modified_gmt":"2024-03-13T01:19:57","slug":"bacteria-based-cancer-therapy-use-tnf-%ce%b1-to-mediate-trojan-horse","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/9671\/","title":{"rendered":"Bacteria-based cancer therapy: use TNF-\u03b1 to mediate Trojan Horse"},"content":{"rendered":"<p>Institute of Biomedical Sciences assistant research fellow Dr. Kurt Yun Mou\u2019s team developed a novel cancer therapy and published their results in \u201cMolecular Therapy\u201d in April this year. The research group develop a Trojan Horse approach to target TNF-\u03b1 for cancer therapy. They employed phage\/yeast display to select non-neutralizing antibodies that can piggyback on TNF-\u03b1 and co-internalize into cells. The antibody conjugated with toxins killed cancer cells in a TNF-\u03b1-dependent manner. Intratumoral injection of engineered <em>E. coli<\/em> secreting the immunotoxin greatly inhibited the tumor growth in mice and enhanced the anti-tumor tumor-infiltrating immune cells, including N1 neutrophils, M1 macrophages, and activated CD4+ and CD8+ lymphocytes. The results were published in <em>Molecular Therapy<\/em>.<\/p>\n<p>Article Link: <a href=\"https:\/\/www.cell.com\/molecular-therapy-family\/molecular-therapy\/fulltext\/S1525-0016(22)00237-4\">https:\/\/www.cell.com\/molecular-therapy-family\/molecular-therapy\/fulltext\/S1525-0016(22)00237-4<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-9672 aligncenter\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-1024x615.jpg\" alt=\"\" width=\"1024\" height=\"615\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-1024x615.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-300x180.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-768x462.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-1080x649.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-1280x768.jpg 1280w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-627x376.jpg 627w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14-440x264.jpg 440w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/05\/webimage-14.jpg 1396w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Institute of Biomedical Sciences assistant research fellow Dr. Kurt Yun Mou\u2019s team developed a novel cancer therapy and published their results in \u201cMolecular Therapy\u201d in April this year. The research group develop a Trojan Horse approach to target TNF-\u03b1 for cancer therapy. They employed phage\/yeast display to select non-neutralizing antibodies that can piggyback on TNF-\u03b1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9672,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9671"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=9671"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9671\/revisions"}],"predecessor-version":[{"id":13197,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9671\/revisions\/13197"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/9672"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=9671"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=9671"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=9671"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}