{"id":9311,"date":"2022-02-24T00:17:13","date_gmt":"2022-02-23T16:17:13","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=9311"},"modified":"2024-03-13T09:19:57","modified_gmt":"2024-03-13T01:19:57","slug":"a-novel-il-18-mediated-anti-bacterial-circuit-to-enforce-intestinal-host-defense-and-immunity","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/9311\/","title":{"rendered":"A novel IL-18-mediated anti-bacterial circuit to enforce intestinal host defense and immunity"},"content":{"rendered":"<p>Tissue-protective cytokine IL-22 targets epithelial lineages such as the gastrointestinal system. Clinical relevance of IL-22 to IBD is well-established and IL-22 therapy is promising for IBD treatment as IL-22 is capable of promoting epithelial repair and inducing production of anti-microbial peptides. A work in <em>Nature Communications<\/em> conducted by Dr. Jr-Wen Shui at Institute of Biomedical Sciences, identify a novel anti-bacterial circuit, showing during E coli infection, IL-22 initiates an IL-18 epithelial response circuit to enforce immunity, which provides therapeutic insights of using IL-22\/IL-18 as a potential anti-inflammatory target.<\/p>\n<p>For further information\uff1a<a href=\"https:\/\/www.ibms.sinica.edu.tw\/en\/news\/2022-418.html\">https:\/\/www.ibms.sinica.edu.tw\/en\/news\/2022-418.html<\/a><br \/>\nArticle link: <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-28478-3\">https:\/\/www.nature.com\/articles\/s41467-022-28478-3<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-9312 aligncenter\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-1024x615.jpg\" alt=\"\" width=\"1024\" height=\"615\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-1024x615.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-300x180.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-768x462.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-1080x649.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-1280x768.jpg 1280w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-627x376.jpg 627w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15-440x264.jpg 440w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/02\/image1-15.jpg 1396w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tissue-protective cytokine IL-22 targets epithelial lineages such as the gastrointestinal system. Clinical relevance of IL-22 to IBD is well-established and IL-22 therapy is promising for IBD treatment as IL-22 is capable of promoting epithelial repair and inducing production of anti-microbial peptides. A work in Nature Communications conducted by Dr. Jr-Wen Shui at Institute of Biomedical [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9312,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9311"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=9311"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9311\/revisions"}],"predecessor-version":[{"id":13202,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9311\/revisions\/13202"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/9312"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=9311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=9311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=9311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}