{"id":9262,"date":"2022-01-27T00:19:00","date_gmt":"2022-01-26T16:19:00","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=9262"},"modified":"2024-03-13T09:19:57","modified_gmt":"2024-03-13T01:19:57","slug":"a-novel-optical-microscope-technique-reveals-chromatin-dynamics-in-live-cells","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/9262\/","title":{"rendered":"A Novel Optical Microscope Technique Reveals Chromatin Dynamics in Live Cells"},"content":{"rendered":"<p>Chromatin organization and dynamics underlie various important nuclear activities. Dr. Chia-Lung Hsieh\u2019s research team at Institute of Atomic and Molecular Sciences,Academia Sinca has developed a novel optical microscope technique that enables high-resolution chromatin imaging in live cell nuclei without the need of labeling. This new technique measures the linear scattering signal from the unlabeled chromatin. By analyzing the temporally dynamic signal, a high-resolution chromatin map is reconstructed. Collaborating with cell biologists, the team explores important nuclear biology, including cancer and aging.<\/p>\n<p>\uff0eFor further information: <a href=\"https:\/\/www.iams.sinica.edu.tw\/en\/?link=show_rea&amp;id=256\">https:\/\/www.iams.sinica.edu.tw\/en\/?link=show_rea&amp;id=256<\/a><br \/>\n\uff0eMovie: <a href=\"https:\/\/pubs.acs.org\/doi\/suppl\/10.1021\/acsnano.1c09748\/suppl_file\/nn1c09748_si_005.mp4\">Transient nanocondensation of chromatin captured by continuous time-lapse DYNAMICS imaging<\/a><br \/>\n\uff0eArticle Link: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.1c09748\">https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.1c09748<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-9263 aligncenter\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-1024x615.jpg\" alt=\"\" width=\"1024\" height=\"615\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-1024x615.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-300x180.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-768x461.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-1080x648.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-1280x768.jpg 1280w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-627x376.jpg 627w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06-440x264.jpg 440w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage2-06.jpg 1396w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chromatin organization and dynamics underlie various important nuclear activities. Dr. Chia-Lung Hsieh\u2019s research team at Institute of Atomic and Molecular Sciences,Academia Sinca has developed a novel optical microscope technique that enables high-resolution chromatin imaging in live cell nuclei without the need of labeling. This new technique measures the linear scattering signal from the unlabeled chromatin. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9263,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9262"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=9262"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9262\/revisions"}],"predecessor-version":[{"id":13203,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9262\/revisions\/13203"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/9263"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=9262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=9262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=9262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}