{"id":9230,"date":"2022-01-13T00:29:01","date_gmt":"2022-01-12T16:29:01","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=9230"},"modified":"2024-03-13T09:19:58","modified_gmt":"2024-03-13T01:19:58","slug":"pias1-variant-s510g-is-a-protective-genetic-modifier-of-huntingtons-disease","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/9230\/","title":{"rendered":"PIAS1 Variant S510G is a protective genetic modifier of Huntington\u2019s disease"},"content":{"rendered":"<p>CAG repeat length is a determinant of the age-at-onset of polyglutamine-related diseases, including Huntington\u2019s disease. Some patients have significantly earlier or later age-at-onset, suggesting the presence of genetic modifier(s). A work in <em>Movement Disorders<\/em> conducted by Dr. Yijuang Chern\u2019s group, at the Institute of Biomedical Sciences, demonstrated that PIAS1 is a genetic modifier of polyglutamine diseases. The naturally occurring variant PIAS1S510G interacts with mHTT poorly and thus lowers the SUMOylation and accumulation of mHTT. Knock-in of PIAS1S510G ameliorates Huntington\u2019s disease phenotypes in mice. PIAS1 is a drug target for HD.<\/p>\n<p>Article link\uff1a<a href=\"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28896\">https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28896<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-9231 aligncenter\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-1024x615.jpg\" alt=\"\" width=\"1024\" height=\"615\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-1024x615.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-300x180.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-768x462.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-1080x649.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-1280x768.jpg 1280w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-627x376.jpg 627w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13-440x264.jpg 440w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/01\/webimage-13.jpg 1396w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>CAG repeat length is a determinant of the age-at-onset of polyglutamine-related diseases, including Huntington\u2019s disease. Some patients have significantly earlier or later age-at-onset, suggesting the presence of genetic modifier(s). A work in Movement Disorders conducted by Dr. Yijuang Chern\u2019s group, at the Institute of Biomedical Sciences, demonstrated that PIAS1 is a genetic modifier of polyglutamine [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":9231,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9230"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=9230"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9230\/revisions"}],"predecessor-version":[{"id":13205,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/9230\/revisions\/13205"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/9231"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=9230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=9230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=9230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}