{"id":8912,"date":"2021-10-07T00:03:48","date_gmt":"2021-10-06T16:03:48","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=8912"},"modified":"2024-03-13T09:19:58","modified_gmt":"2024-03-13T01:19:58","slug":"pdia4-regulates-%ce%b2-cell-pathogenesis-in-diabetes-molecular-mechanism-and-targeted-therapy","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/8912\/","title":{"rendered":"Pdia4 regulates \u03b2-cell pathogenesis in diabetes: molecular mechanism and targeted therapy"},"content":{"rendered":"<p>Diabetes has been incurable due to \u03b2-cell death and dysfunction in patients. \u03b2-cell preservation is thus emerging as a promising strategy to treat and reverse diabetes. A recent study by Dr. Wen-Chin Yang\u2019s research group at the Research Center of Agricultural Biotechnology, identified Pdia4, a key regulator of \u03b2-cell failure, as a novel therapeutic target of diabetes. Pre-clinical studies of a Pdia4 inhibitor, PS1, were completed and PS1 is now ready for the application of investigational drug to FDA and clinical trials. This study has been published in <em>EMBO Molecular Medicine<\/em> on September, 2021.<\/p>\n<p>Article Link: <a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.201911668\">https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.201911668<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-8913 aligncenter\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/10\/\u6f2b\u6b65\u79d1\u7814_\u7cd6\u5c3f\u75c5\u82f1.jpg\" alt=\"\" width=\"836\" height=\"504\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/10\/\u6f2b\u6b65\u79d1\u7814_\u7cd6\u5c3f\u75c5\u82f1.jpg 836w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/10\/\u6f2b\u6b65\u79d1\u7814_\u7cd6\u5c3f\u75c5\u82f1-300x181.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/10\/\u6f2b\u6b65\u79d1\u7814_\u7cd6\u5c3f\u75c5\u82f1-768x463.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/10\/\u6f2b\u6b65\u79d1\u7814_\u7cd6\u5c3f\u75c5\u82f1-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diabetes has been incurable due to \u03b2-cell death and dysfunction in patients. \u03b2-cell preservation is thus emerging as a promising strategy to treat and reverse diabetes. A recent study by Dr. Wen-Chin Yang\u2019s research group at the Research Center of Agricultural Biotechnology, identified Pdia4, a key regulator of \u03b2-cell failure, as a novel therapeutic target [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8913,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8912"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=8912"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8912\/revisions"}],"predecessor-version":[{"id":13213,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8912\/revisions\/13213"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/8913"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=8912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=8912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=8912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}