Diabetes has been incurable due to \u03b2-cell death and dysfunction in patients. \u03b2-cell preservation is thus emerging as a promising strategy to treat and reverse diabetes. A recent study by Dr. Wen-Chin Yang\u2019s research group at the Research Center of Agricultural Biotechnology, identified Pdia4, a key regulator of \u03b2-cell failure, as a novel therapeutic target of diabetes. Pre-clinical studies of a Pdia4 inhibitor, PS1, were completed and PS1 is now ready for the application of investigational drug to FDA and clinical trials. This study has been published in EMBO Molecular Medicine<\/em> on September, 2021.<\/p>\n

Article Link: https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.201911668<\/a><\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Diabetes has been incurable due to \u03b2-cell death and dysfunction in patients. \u03b2-cell preservation is thus emerging as a promising strategy to treat and reverse diabetes. A recent study by Dr. Wen-Chin Yang\u2019s research group at the Research Center of Agricultural Biotechnology, identified Pdia4, a key regulator of \u03b2-cell failure, as a novel therapeutic target […]<\/p>\n","protected":false},"author":1,"featured_media":8913,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8912"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=8912"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8912\/revisions"}],"predecessor-version":[{"id":13213,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8912\/revisions\/13213"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/8913"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=8912"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=8912"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=8912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}