{"id":8604,"date":"2021-08-26T00:03:47","date_gmt":"2021-08-25T16:03:47","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=8604"},"modified":"2024-03-13T09:19:58","modified_gmt":"2024-03-13T01:19:58","slug":"neutralizing-eno1-prevents-lung-cancer-cell-growth-and-metastasis","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/8604\/","title":{"rendered":"Neutralizing ENO1 prevents lung cancer cell growth and metastasis"},"content":{"rendered":"<p>A recent study by Dr. Han-Chung Wu\u2019s group at the Institute of Cellular and Organismic Biology, Academia Sinica, has greatly advanced our knowledge of how ENO1 (\u03b1-enolase) acts to promote cancer cell growth and how that process can be stopped. The study was published in the world-renowned journal, Cancer Research, and showed that ENO1 activates two promoting tumor metastatic signaling pathways to stabilize metastasis-promoting factor, SLUG, which promotes epithelial-mesenchymal transition and invasion\/metastasis in lung cancer.<\/p>\n<p>Article Link: <a href=\"https:\/\/cancerres.aacrjournals.org\/content\/81\/15\/4094\">https:\/\/cancerres.aacrjournals.org\/content\/81\/15\/4094<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-8605 aligncenter\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14-1024x616.jpg\" alt=\"\" width=\"1024\" height=\"616\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14-1024x616.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14-300x180.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14-768x462.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14-1080x649.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14-627x376.jpg 627w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14-440x264.jpg 440w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2021\/08\/webimage-14.jpg 1467w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study by Dr. Han-Chung Wu\u2019s group at the Institute of Cellular and Organismic Biology, Academia Sinica, has greatly advanced our knowledge of how ENO1 (\u03b1-enolase) acts to promote cancer cell growth and how that process can be stopped. The study was published in the world-renowned journal, Cancer Research, and showed that ENO1 activates [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8605,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8604"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=8604"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8604\/revisions"}],"predecessor-version":[{"id":13220,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/8604\/revisions\/13220"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/8605"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=8604"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=8604"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=8604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}