{"id":7230,"date":"2020-06-04T00:00:23","date_gmt":"2020-06-03T16:00:23","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=7230"},"modified":"2024-03-13T09:18:15","modified_gmt":"2024-03-13T01:18:15","slug":"a-promising-trisaccharide-identified-for-damaged-cartilage","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/7230\/","title":{"rendered":"A Promising Trisaccharide Identified for Damaged Cartilage"},"content":{"rendered":"

“Bad Knees” is not an unfamiliar topic among older folks. Most of the complaints are pains and swellings, accompanying clicking and locking at the joints. Some people believe it\u2019s a sign of ageing when one starts feeling funny at the knees. And it may just be true! Although the disease has been long recognized, the exact cause remains unknown. A team led by Professor Shang-Cheng Hung, Professor Chi-Huey Wong and Dr. Rachel Cheng dug into this problem around seven years ago.<\/p>\n

Now, a report of how a trisaccharide structure was proved to be the ultimate substrate to en-do-O-sulfatase-1(Sulf-1) has been published. They have not only unraveled the key to a known mystery but also proposed a structure as a potential inhibitor to solve the problem. The detail was published in Journal of the American Chemical Society (JACS)<\/em>.<\/p>\n

The original article can be read online at the JACS website: https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.0c00005<\/a><\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

“Bad Knees” is not an unfamiliar topic among older folks. Most of the complaints are pains and swellings, accompanying clicking and locking at the joints. Some people believe it\u2019s a sign of ageing when one starts feeling funny at the knees. And it may just be true! Although the disease has been long recognized, the […]<\/p>\n","protected":false},"author":1,"featured_media":7231,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[535],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/7230"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=7230"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/7230\/revisions"}],"predecessor-version":[{"id":13114,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/7230\/revisions\/13114"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/7231"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=7230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=7230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=7230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}