{"id":11592,"date":"2023-04-20T00:05:02","date_gmt":"2023-04-19T16:05:02","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=11592"},"modified":"2024-03-13T09:19:02","modified_gmt":"2024-03-13T01:19:02","slug":"structure-of-the-heterotrimeric-membrane-protein-complex-ftsb-ftsl-ftsq-of-the-bacterial-divisome","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/11592\/","title":{"rendered":"Structure of the heterotrimeric membrane protein complex FtsB-FtsL-FtsQ of the bacterial divisome"},"content":{"rendered":"
Membrane protein FtsB-FtsL-FtsQ (FtsBLQ) complex are essential component of divisome, which play important roles in the divisome assembling and the division-mediated peptidoglycan synthesis regulation, yet with the unclear mechanism. In the latest publication in Nature Communications, a crystal structure of the trimeric FtsB-FtsL-FtsQ complex was revealed for the first time, from a fruitful collaboration between Dr. Che Alex Ma\u2019s lab in the Genomics Research Center and Dr. Yu-Ling Shih\u2019s lab in the Institute of Biological Chemistry. A structure-based model that delineates the mechanism of the regulation of peptidoglycan synthases by the FtsBLQ complex were also proposed accordingly in this study.<\/p>\n