{"id":11550,"date":"2023-03-23T00:03:06","date_gmt":"2023-03-22T16:03:06","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=11550"},"modified":"2024-03-13T09:19:02","modified_gmt":"2024-03-13T01:19:02","slug":"a-microrna-aiding-in-the-battle-against-spinal-muscular-atrophy","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/11550\/","title":{"rendered":"A MicroRNA Aiding in the Battle against Spinal Muscular Atrophy"},"content":{"rendered":"<p>A collaborative study by Dr. <a href=\"https:\/\/www.imb.sinica.edu.tw\/en\/faculty\/profile\/jachen.html\" rel=\"noopener\" target=\"_blank\">Jun-An Chen<\/a>\u2019s group at the Institute of Molecular Biology, Academia Sinica, and Dr. <a href=\"https:\/\/www.kmuh.org.tw\/english\/main2_docData.asp?noframe=&#038;cid=0970418047&#038;DeptCode=0400&#038;DeptName=%EF%BF%BDp%EF%BF%BD%EF%BF%BD%EF%BF%BD&#038;subdeptname=Department+of+Pediatrics&#038;empNO=680026\" rel=\"noopener\" target=\"_blank\">Yuh-Jyh Jong<\/a>\u2019s group at Kaohsiung Medical University has uncovered that a family of small regulatory RNAs, namely microRNA-34 or MiR34, is associated with disease progression of Spinal muscular atrophy (SMA) and could potentially be applied as a clinical biomarker to assess the efficacy of medical treatments. This discovery provides new insights into how small RNAs participate in SMA pathology and represents a novel way to assist a new SMA treatment protocol. The study has been published in <em>Molecular Therapy \u2013 Nucleic Acids<\/em>. <\/p>\n<p>This study was funded by Academia Sinica, KMU and KMU Hospital, National Health Research Institutes, and the National Science and Technology Council in Taiwan.<\/p>\n<p>Link to the full article: <a href=\"https:\/\/doi.org\/10.1016\/j.omtn.2023.03.005\">https:\/\/doi.org\/10.1016\/j.omtn.2023.03.005<\/a><br \/>\nMore information: <a href=\"https:\/\/www.imb.sinica.edu.tw\/en\/research\/publication_show.php?pid=230\"> https:\/\/www.imb.sinica.edu.tw\/en\/research\/publication_show.php?pid=230<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-2.jpg\" alt=\"A MicroRNA Aiding in the Battle against Spinal Muscular Atrophy\" width=\"796\" height=\"472\" class=\"aligncenter size-full wp-image-11565\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-2.jpg 796w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-2-300x178.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-2-768x455.jpg 768w\" sizes=\"(max-width: 796px) 100vw, 796px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A collaborative study by Dr. Jun-An Chen\u2019s group at the Institute of Molecular Biology, Academia Sinica, and Dr. Yuh-Jyh Jong\u2019s group at Kaohsiung Medical University has uncovered that a family of small regulatory RNAs, namely microRNA-34 or MiR34, is associated with disease progression of Spinal muscular atrophy (SMA) and could potentially be applied as a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11557,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11550"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=11550"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11550\/revisions"}],"predecessor-version":[{"id":13154,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11550\/revisions\/13154"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/11557"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=11550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=11550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=11550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}