{"id":11372,"date":"2023-03-09T00:05:15","date_gmt":"2023-03-08T16:05:15","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=11372"},"modified":"2024-03-13T09:19:02","modified_gmt":"2024-03-13T01:19:02","slug":"circulating-androgen-regulation-by-androgen-catabolizing-gut-bacteria-in-male-mouse-gut","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/11372\/","title":{"rendered":"Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut"},"content":{"rendered":"<p>Abnormally high circulating androgen levels have been considered a causative factor for benign prostatic hypertrophy and prostate cancer in men. <em>Thauera<\/em> sp. strain GDN1 is an unusual betaproteobacterium capable of catabolizing androgens. <\/p>\n<p>The collaborative team led by Research Fellow Yin-Ru Chiang from the Biodiversity Research Center, Academia Sinica, and Professor Mei-Jou Chen from the Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, National Taiwan University, administered C57BL\/6 mice with strain GDN1 through oral gavage. The team found that the administered strain GDN1 regulated mouse serum androgen levels, possibly because it blocked androgen recycling through enterohepatic circulation. The team\u2019s data thus indicate the possible applicability of androgen-catabolic gut bacteria as potent probiotics in alternative therapy of hyperandrogenism. <\/p>\n<p>This study \u201cCirculating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut\u201d was published in <em>Gut Microbes<\/em> in February 2023.<\/p>\n<p>Link to the full article: <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2023.2183685\">https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/19490976.2023.2183685<\/a><br \/>\nFurther information: <a href=\"https:\/\/www.biodiv.tw\/research-20230307090619\">https:\/\/www.biodiv.tw\/research-20230307090619<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-1-1024x449.jpg\" alt=\"Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut\" width=\"1024\" height=\"449\" class=\"aligncenter size-large wp-image-11373\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-1-1024x449.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-1-300x131.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-1-768x336.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-1-1536x673.jpg 1536w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-1-1080x473.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/03\/3-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abnormally high circulating androgen levels have been considered a causative factor for benign prostatic hypertrophy and prostate cancer in men. Thauera sp. strain GDN1 is an unusual betaproteobacterium capable of catabolizing androgens. The collaborative team led by Research Fellow Yin-Ru Chiang from the Biodiversity Research Center, Academia Sinica, and Professor Mei-Jou Chen from the Department [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11374,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11372"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=11372"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11372\/revisions"}],"predecessor-version":[{"id":13155,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11372\/revisions\/13155"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/11374"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=11372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=11372"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=11372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}