{"id":11017,"date":"2023-01-12T00:04:18","date_gmt":"2023-01-11T16:04:18","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=11017"},"modified":"2024-03-13T09:19:03","modified_gmt":"2024-03-13T01:19:03","slug":"the-circles-part-ii-investigating-causal-relationship-between-genetic-variants-and-circular-rna-expression-in-autism","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/11017\/","title":{"rendered":"The circles Part II: investigating causal relationship between genetic variants and circular RNA expression in autism"},"content":{"rendered":"<p>By integrating RNA-sequencing with genotype data from autistic brains, the research team led by Dr. Trees-Juen Chuang\u2019s group at Genomics Research center, Academia Sinica assessed expression quantitative trait loci of circRNAs (circQTLs) that <em>cis<\/em>-regulate expression of nearby circRNAs and <em>trans<\/em>-regulate expression of distant genes (<em>trans<\/em>-eGenes) simultaneously. The study provided the first framework for systematically investigating <em>trans<\/em>-genetic effects of circQTLs and inferring the corresponding causal relations in ASD. The identified circQTL-circRNA-<em>trans<\/em>-eGene regulatory interactions also provided a helpful dataset for further investigating causative biology and cryptic regulatory mechanisms underlying the neuropsychiatric diseases. This result was recently published in <em>Molecular Psychiatry<\/em>.<\/p>\n<p>For further information:<a href=\"https:\/\/www.genomics.sinica.edu.tw\/index.php\/en\/news\/lastest-news\/707-part-ii-rna\">https:\/\/www.genomics.sinica.edu.tw\/index.php\/en\/news\/lastest-news\/707-part-ii-rna<\/a><br \/>\nArticle link:\u2028<a href=\"https:\/\/www.nature.com\/articles\/s41380-022-01714-4\">https:\/\/www.nature.com\/articles\/s41380-022-01714-4<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/01\/3-1_E.jpg\" alt=\"The circles Part II: investigating causal relationship between genetic variants and circular RNA expression in autism\" width=\"836\" height=\"504\" class=\"alignnone size-full wp-image-11018\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/01\/3-1_E.jpg 836w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/01\/3-1_E-300x181.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/01\/3-1_E-768x463.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/01\/3-1_E-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>By integrating RNA-sequencing with genotype data from autistic brains, the research team led by Dr. Trees-Juen Chuang\u2019s group at Genomics Research center, Academia Sinica assessed expression quantitative trait loci of circRNAs (circQTLs) that cis-regulate expression of nearby circRNAs and trans-regulate expression of distant genes (trans-eGenes) simultaneously. The study provided the first framework for systematically investigating [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11019,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11017"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=11017"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11017\/revisions"}],"predecessor-version":[{"id":13159,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11017\/revisions\/13159"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/11019"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=11017"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=11017"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=11017"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}