{"id":10777,"date":"2022-12-01T00:05:52","date_gmt":"2022-11-30T16:05:52","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=10777"},"modified":"2024-03-13T09:19:03","modified_gmt":"2024-03-13T01:19:03","slug":"mechanism-in-the-switch-controlling-cell-death-cascade-identified","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/10777\/","title":{"rendered":"Mechanism in the switch controlling cell death cascade identified"},"content":{"rendered":"<p>A research team led by Dr. Ming-Zong Lai at the Institute of Molecular Biology, together with Dr. Shie-Liang Hsieh from Genomic Research Center, discovered a key switch control in the sequential cell death cascade critical for limiting intracellular pathogen replication. Dr. Lai\u2019s team show that caspase-8 inactivation induces pyroptosis in myeloid cells deficient in apoptosis and necroptosis, which is mediated by atypical inflammasome activated by autophagy and cathepsin-B. This study was published in <em>Science Advances<\/em>. <\/p>\n<p>Further information:<a href=\"http:\/\/www.imb.sinica.edu.tw\/en\/research\/research_show.php?rrid=225\"> http:\/\/www.imb.sinica.edu.tw\/en\/research\/research_show.php?rrid=225<\/a><br \/>\nArticle link: <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.abn9912\">https:\/\/www.science.org\/doi\/10.1126\/sciadv.abn9912<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-1-995x1024.jpg\" alt=\"Mechanism in the switch controlling cell death cascade identified\" width=\"995\" height=\"1024\" class=\"alignnone size-large wp-image-10778\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-1-995x1024.jpg 995w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-1-292x300.jpg 292w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-1-768x790.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-1-1080x1111.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-1.jpg 1217w\" sizes=\"(max-width: 995px) 100vw, 995px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A research team led by Dr. Ming-Zong Lai at the Institute of Molecular Biology, together with Dr. Shie-Liang Hsieh from Genomic Research Center, discovered a key switch control in the sequential cell death cascade critical for limiting intracellular pathogen replication. Dr. Lai\u2019s team show that caspase-8 inactivation induces pyroptosis in myeloid cells deficient in apoptosis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10779,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10777"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=10777"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10777\/revisions"}],"predecessor-version":[{"id":13164,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10777\/revisions\/13164"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/10779"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=10777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=10777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=10777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}