{"id":10765,"date":"2022-12-01T00:02:55","date_gmt":"2022-11-30T16:02:55","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=10765"},"modified":"2024-03-13T09:19:03","modified_gmt":"2024-03-13T01:19:03","slug":"mex3a-mediates-p53-degradation-to-suppress-ferroptosis-and-facilitate-ovarian-cancer-tumorigenesis","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/10765\/","title":{"rendered":"MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis"},"content":{"rendered":"<p>Ovarian cancer is a highly heterogeneous and malignant female cancer with an overall low survival rate. In particular, advanced ovarian clear cell carcinoma with wildtype p53 has a poor prognosis, drug resistance, metastasis and recurrence. The research team of Dr. Wendy W. Hwang-Verslues at Genomics Research Center found that MEX3A facilitates p53 degradation to drive ovarian cancer growth by circumventing p53-mediated ferroptosis. These findings suggest that targeting MEX3A can be a potential strategy for treating of ovarian cancer expressing wildtype p53 and were published in <em>Cancer Research<\/em>.<\/p>\n<p>For further information<br \/>\n<a href=\"https:\/\/www.genomics.sinica.edu.tw\/index.php\/tw\/news\/lastest-news\/701-mex3a-p53\">https:\/\/www.genomics.sinica.edu.tw\/index.php\/tw\/news\/lastest-news\/701-mex3a-p53<\/a><\/p>\n<p>Article link:<br \/>\n<a href=\"https:\/\/aacrjournals.org\/cancerres\/article\/doi\/10.1158\/0008-5472.CAN-22-1159\/710535\/MEX3A-mediates-p53-degradation-to-suppress\">https:\/\/aacrjournals.org\/cancerres\/article\/doi\/10.1158\/0008-5472.CAN-22-1159\/710535\/MEX3A-mediates-p53-degradation-to-suppress<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-4-1024x617.jpg\" alt=\"MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis\" width=\"1024\" height=\"617\" class=\"alignnone size-large wp-image-10766\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-4-1024x617.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-4-300x181.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-4-768x463.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-4-1080x651.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-4-440x264.jpg 440w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/11\/3-4.jpg 1162w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ovarian cancer is a highly heterogeneous and malignant female cancer with an overall low survival rate. In particular, advanced ovarian clear cell carcinoma with wildtype p53 has a poor prognosis, drug resistance, metastasis and recurrence. The research team of Dr. Wendy W. Hwang-Verslues at Genomics Research Center found that MEX3A facilitates p53 degradation to drive [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10767,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10765"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=10765"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10765\/revisions"}],"predecessor-version":[{"id":13167,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10765\/revisions\/13167"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/10767"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=10765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=10765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=10765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}