{"id":10440,"date":"2022-10-20T00:04:49","date_gmt":"2022-10-19T16:04:49","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=10440"},"modified":"2024-03-13T09:19:03","modified_gmt":"2024-03-13T01:19:03","slug":"liver-maintains-systemic-memory-cytotoxic-t-cell-immunity-indefinitely","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/10440\/","title":{"rendered":"Liver maintains systemic memory cytotoxic T cell immunity indefinitely"},"content":{"rendered":"<p>The goal of vaccination is to achieve long-lasting protection through the development of antigen-specific memory cells. Current COVID-19 vaccines induce good early immune responses, but are sub-optimal in the maintenance phase, resulting in short- but not long-term protection. Dr. Kung, John, research fellow in the Institute of Molecular Biology, Academia Sinica, identified hepatic stellate cell as the cell capable of sustaining memory CD8+ T cells survival and functionality indefinitely. He conclude that the liver, the largest organ of our body, contributes significantly to memory CD8+ T cell longevity; these findings have significant implications for vaccine development. This study was published in <em>Hepatology<\/em>.<\/p>\n<p>Article link: <a href=\"https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/10.1002\/hep.32788\">https:\/\/aasldpubs.onlinelibrary.wiley.com\/doi\/10.1002\/hep.32788<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-2.jpg\" alt=\"Liver maintains systemic memory cytotoxic T cell immunity indefinitely\" width=\"896\" height=\"504\" class=\"alignnone size-full wp-image-10442\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-2.jpg 896w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-2-300x169.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-2-768x432.jpg 768w\" sizes=\"(max-width: 896px) 100vw, 896px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The goal of vaccination is to achieve long-lasting protection through the development of antigen-specific memory cells. Current COVID-19 vaccines induce good early immune responses, but are sub-optimal in the maintenance phase, resulting in short- but not long-term protection. Dr. Kung, John, research fellow in the Institute of Molecular Biology, Academia Sinica, identified hepatic stellate cell [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10443,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10440"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=10440"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10440\/revisions"}],"predecessor-version":[{"id":13173,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10440\/revisions\/13173"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/10443"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=10440"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=10440"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=10440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}