{"id":10378,"date":"2022-10-06T00:04:52","date_gmt":"2022-10-05T16:04:52","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=10378"},"modified":"2024-03-13T09:19:04","modified_gmt":"2024-03-13T01:19:04","slug":"phyto-sesquiterpene-lactones-det-and-detd-35-induce-ferroptosis-in-vemurafenib-sensitive-and-resistant-melanoma-via-gpx4-inhibition-and-metabolic-reprogramming","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/10378\/","title":{"rendered":"Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming"},"content":{"rendered":"<p>Melanoma is the most life-threatening form of skin cancer. More than 50% of melanoma patients carry BRAF<sup>V600E<\/sup> mutation, but most patients develop resistance, side effects, and relapse after treatment with BRAF<sup>V600E<\/sup> inhibitor drugs such as vemurafenib. Dr. Lie-Fen Shyur\u2019s team at the Agricultural Biotechnology Research Center discovered that sesquiterpene lactone deoxyelephantopin (DET) and its structurally modified derivative DETD-35 are novel GPX4 inhibitors and ferroptosis inducers through which vemurafenib induced abnormal primary and lipid metabolisms in resistant melanoma were reversed; in turn, vemurafenib drug sensitivity to resistant melanoma was enhanced. DET and DETD-35 show great potential as BRAF<sup>V600E<\/sup> inhibitor drug adjuvants against melanoma. This study was published in <em>Pharmacological Research<\/em>.<\/p>\n<p>For further information:<br \/>\n<a href=\"https:\/\/abrc.sinica.edu.tw\/en\/view.php?aid=6268&#038;wid=2\">https:\/\/abrc.sinica.edu.tw\/en\/view.php?aid=6268&#038;wid=2<\/a><\/p>\n<p>Article link:<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35231572\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35231572\/<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-1.jpg\" alt=\"Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming\" width=\"800\" height=\"311\" class=\"alignnone size-full wp-image-10379\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-1.jpg 800w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-1-300x117.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/10\/3-1-1-768x299.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Melanoma is the most life-threatening form of skin cancer. More than 50% of melanoma patients carry BRAFV600E mutation, but most patients develop resistance, side effects, and relapse after treatment with BRAFV600E inhibitor drugs such as vemurafenib. Dr. Lie-Fen Shyur\u2019s team at the Agricultural Biotechnology Research Center discovered that sesquiterpene lactone deoxyelephantopin (DET) and its structurally [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10380,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10378"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=10378"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10378\/revisions"}],"predecessor-version":[{"id":13175,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10378\/revisions\/13175"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/10380"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=10378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=10378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=10378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}