{"id":10296,"date":"2022-09-22T00:03:45","date_gmt":"2022-09-21T16:03:45","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=10296"},"modified":"2024-03-13T09:19:04","modified_gmt":"2024-03-13T01:19:04","slug":"clec5a-and-tlr2-are-critical-in-sars-cov-2-induced-net-formation-and-lung-inflammation","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/10296\/","title":{"rendered":"CLEC5A and TLR2 are critical in SARS-CoV-2 induced NET formation and lung inflammation"},"content":{"rendered":"<p>Recent studies indicate that high levels of neutrophil extracellular traps (NETs) were detected in COVID-19 patients\u2019 serum and organs. NETs contribute to immunothrombosis, thereby leading to extensive intravascular coagulopathy and multiple organ dysfunctions. A team led by Dr. Shie-Liang Hsieh at the Genomics Research Center, Academia Sinica reported that high level of platelet-derived extracellular vesicles (PLT-EVs) was found in COVID-19 patients, and PLT-EVs contribute to severe immunothrombosis via CLEC5A and TLR2. Thus, blockade of CLEC5A and TLR2 is a novel strategy to prevent SARS-CoV2-induced immunothrombosis.<\/p>\n<p>Article Link:<br \/>\n<a href=\"https:\/\/jbiomedsci.biomedcentral.com\/articles\/10.1186\/s12929-022-00832-z\">https:\/\/jbiomedsci.biomedcentral.com\/articles\/10.1186\/s12929-022-00832-z<\/a><\/p>\n<p>For further information:<br \/>\n<a href=\"https:\/\/www.genomics.sinica.edu.tw\/index.php\/en\/news\/lastest-news\/689-clec5a-tlr2-sars-cov-2\">https:\/\/www.genomics.sinica.edu.tw\/index.php\/en\/news\/lastest-news\/689-clec5a-tlr2-sars-cov-2<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-2-1.jpg\" alt=\"CLEC5A and TLR2 are critical in SARS-CoV-2 induced NET formation and lung inflammation\" width=\"836\" height=\"504\" class=\"alignnone size-full wp-image-10297\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-2-1.jpg 836w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-2-1-300x181.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-2-1-768x463.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-2-1-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent studies indicate that high levels of neutrophil extracellular traps (NETs) were detected in COVID-19 patients\u2019 serum and organs. NETs contribute to immunothrombosis, thereby leading to extensive intravascular coagulopathy and multiple organ dysfunctions. A team led by Dr. Shie-Liang Hsieh at the Genomics Research Center, Academia Sinica reported that high level of platelet-derived extracellular vesicles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10298,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10296"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=10296"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10296\/revisions"}],"predecessor-version":[{"id":13179,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10296\/revisions\/13179"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/10298"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=10296"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=10296"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=10296"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}