{"id":10250,"date":"2022-09-08T00:04:01","date_gmt":"2022-09-07T16:04:01","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=10250"},"modified":"2024-03-13T09:19:04","modified_gmt":"2024-03-13T01:19:04","slug":"trax-is-an-upstream-regulator-of-the-mirna-mrna-axis-and-provides-neuroprotection-for-huntingtons-disease","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/10250\/","title":{"rendered":"TRAX is an upstream regulator of the miRNA-mRNA axis and provides neuroprotection for Huntington\u2019s disease"},"content":{"rendered":"<p>Huntington\u2019s disease (HD) is an inherited neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the <em>HTT<\/em> gene. A work in <em>Movement Disorders<\/em> conducted by Dr. Yijuang Chern\u2019s group, at the Institute of Biomedical Sciences, demonstrated that during HD progression, the level of the Translin-associated protein X (TRAX, a scaffold protein that mediates miRNA degradation) was markedly enhanced in the brain of patients and mice with HD. Such TRAX upregulation is protective in HD, because genetic downregulation of TRAX in the brain of HD mice altered the miRNA-mRNA network and accelerated disease progression. <\/p>\n<p>For further information:<a href=\"https:\/\/www.ibms.sinica.edu.tw\/en\/news\/2022-443.html\"> https:\/\/www.ibms.sinica.edu.tw\/en\/news\/2022-443.html<\/a><br \/>\nArticle link: <a href=\"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29174\">https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.29174<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-1.jpg\" alt=\"TRAX is an upstream regulator of the miRNA-mRNA axis and provides neuroprotection for Huntington\u2019s disease\" width=\"836\" height=\"504\" class=\"alignnone size-full wp-image-10251\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-1.jpg 836w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-1-300x181.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-1-768x463.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2022\/09\/3-1-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Huntington\u2019s disease (HD) is an inherited neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the HTT gene. A work in Movement Disorders conducted by Dr. Yijuang Chern\u2019s group, at the Institute of Biomedical Sciences, demonstrated that during HD progression, the level of the Translin-associated protein X (TRAX, a scaffold protein that mediates miRNA [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10252,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10250"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=10250"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10250\/revisions"}],"predecessor-version":[{"id":13180,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/10250\/revisions\/13180"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/10252"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=10250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=10250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=10250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}