A research team led by Dr. Wen-Hwa Lee and Dr. Chun-Mei Hu from the Genomics Research Center revealed how PDAC tumor cells recruit nearby cells, called fibroblasts, to work as their helpers at tumor-stromal boundaries through direct tumor-fibroblast interaction. These interactions in PDAC progression enhance cancer cell migration and make the tumors more malignant. Blockage of direct contact between tumor cells and fibroblasts may represent a promising therapeutic strategy for patients with PDAC. This research was published in Nature Communications in May 2022.

Article Link: https://doi.org/10.1038/s41467-022-30638-4

PDAC tumor cell-fibroblast interactions promote metastasis via Homophilic ATP1A1 Binding