Dr. Kuen-Phon Wu received his Ph.D. in the State University of New Jersey, USA. Dr. Wu’s research focuses on the molecular mechanism of HERC5 E3-mediated ubiquitination in innate immune responses. HERC5 utilizes a ubiquitin-like molecular called ISG15 to modify and promote degradation of viral or bacterial proteins as an important defending responses. To fully unveil the HERC5-mediated innate immune response, structural biology provides great tools to discover details of protein-protein interactions. Dr. Wu will combine solution nuclear magnetic resonance (NMR) X-ray crystallography and cryo-electron micropscopy (cryoEM) to characterize dynamic and transient reactions, allosteric activation and complex structures. The outcome will provide chances in advanced drug design for antiviral response.
Dr. Wu was appointed as the Assistant Research Fellow of the Institute of Biological Chemistry in November, 2018. For more information about his research, please refer to the following website: http://www.ibc.sinica.edu.tw/PI_DetailE.asp?Auto=62