Dr. Shang-Te Danny Hsu at the Institute of Biological Chemistry reported the molecular basis of the nuclear import of an important oncogene suppressor, BAP1, which is governed by an atypical nuclear import factor called TNPO1. TNPO1 binding to the atypical nuclear localization signal (NLS) of BAP1, known as the PY-motif, prevents the competing action of an atypical E2/E3 conjugating enzyme, UBE2O, which favors cytosolic retention of BAP1. The study expands our fundamental understanding of BAP1 cancer biology. The article has published in the Journal of Cell Biology on June 6, 2022.

Article Link: https://doi.org/10.1083/jcb.202201094

Molecular insights of how cancer risk factor BAP1 nuclear import is regulated by TNPO1