{"id":33364,"date":"2023-12-14T00:24:12","date_gmt":"2023-12-13T16:24:12","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=33364"},"modified":"2023-12-14T04:09:35","modified_gmt":"2023-12-13T20:09:35","slug":"%e7%9c%8b%e5%88%b0%e4%ba%86%ef%bc%81%e5%9c%a8%e5%8e%9f%e5%ad%90%e8%a7%a3%e6%9e%90%e5%ba%a6%e4%b8%8b%e7%9b%b4%e6%93%8a-dna-%e5%85%89%e8%a7%a3%e9%85%b6%e9%85%b5%e7%b4%a0%e7%9a%84%e4%bf%ae%e5%be%a9","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/33364\/","title":{"rendered":"\u770b\u5230\u4e86\uff01\u5728\u539f\u5b50\u89e3\u6790\u5ea6\u4e0b\u76f4\u64ca DNA \u5149\u89e3\u9176\u9175\u7d20\u7684\u4fee\u5fa9\u904e\u7a0b"},"content":{"rendered":"<p>DNA \u640d\u50b7\u6709\u591a\u7a2e\u985e\u578b\uff0c\u662f\u5c0e\u81f4\u764c\u75c7\u6216\u907a\u50b3\u6027\u75be\u75c5\u7684\u81f4\u75c5\u539f\u56e0\u4e4b\u4e00\uff0c\u751f\u7269\u9ad4\u5c0d\u6b64\u9032\u5316\u51fa\u4e0d\u540c\u7684\u4fee\u5fa9\u6a5f\u5236\uff0c\u4f46\u5176\u4fee\u5fa9\u904e\u7a0b\u4ecd\u662f\u672a\u89e3\u4e4b\u8b0e\u3002\u7531\u4e2d\u592e\u7814\u7a76\u9662\u8521\u660e\u9053\u9662\u58eb\u9818\u5c0e\u7684\u570b\u969b\u7814\u7a76\u5718\u968a\uff0c\u5229\u7528 X \u5c04\u7dda\u81ea\u7531\u96fb\u5b50\u96f7\u5c04\uff0c\u5728\u6975\u77ed\u7684\u6642\u9593\u5167\u70ba\u53cd\u61c9\u7d50\u69cb\u62cd\u7167\uff0c\u9996\u6b21\u5728\u539f\u5b50\u89e3\u6790\u5ea6\u4e0b\u76f4\u64ca\u5149\u89e3\u9176\u9175\u7d20\u4fee\u5fa9 DNA \u640d\u50b7\u7684\u5b8c\u6574\u904e\u7a0b\u3002\u6b64\u7814\u7a76\u6210\u679c\u5df2\u65bc\u672c\uff082023\uff09\u5e74 12 \u6708 1 \u65e5\u767c\u8868\u65bc\u9802\u5c16\u79d1\u5b78\u671f\u520a\u300a\u79d1\u5b78\u300b\uff08<em>Science<\/em>\uff09\u3002<\/p>\n<p><div id=\"attachment_21652\" style=\"width: 1034px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-21652\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/12\/1-3-1024x693.jpg\" alt=\"\u770b\u5230\u4e86\uff01\u5728\u539f\u5b50\u89e3\u6790\u5ea6\u4e0b\u76f4\u64ca DNA \u5149\u89e3\u9176\u9175\u7d20\u7684\u4fee\u5fa9\u904e\u7a0b\" width=\"1024\" height=\"693\" class=\"aligncenter size-large wp-image-33365\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/12\/1-3-1024x693.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/12\/1-3-300x203.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/12\/1-3-768x520.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/12\/1-3-1536x1040.jpg 1536w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/12\/1-3-1080x731.jpg 1080w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/12\/1-3.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><p id=\"caption-attachment-21652\" class=\"wp-caption-text\">\u25b2\u672c\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u8521\u660e\u9053\u9662\u58eb\uff08\u5de6\uff09\u3001\u570b\u7acb\u81fa\u7063\u5927\u5b78\u5316\u5b78\u7cfb\u99ac\u5de6\u4ef2\uff08Manuel Maestre-Reyna\uff09\u52a9\u7406\u6559\u6388\uff08\u53f3\uff09\u3002<\/p><\/div><br \/>\n&nbsp;<\/p>\n<p><strong>\u4f7f\u7528 XFEL \u6280\u8853 \u5feb\u901f\u9023\u62cd\u5149\u89e3 \u50ac\u5316\u4fee\u5fa9 DNA \u640d\u50b7\u904e\u7a0b<\/strong><\/p>\n<p>\u96a8\u8457 X \u5c04\u7dda\u6676\u9ad4\u5b78\u548c\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u6280\u8853\u7684\u767c\u5c55\uff0c\u79d1\u5b78\u5bb6\u5df2\u7d93\u53ef\u4ee5\u7528\u539f\u5b50\u7b49\u7d1a\u7684\u89e3\u6790\u5ea6\u5206\u6790\u8a31\u591a\u9175\u7d20\u548c\u9175\u7d20\u8907\u5408\u9ad4\u7684\u7d50\u69cb\uff0c\u7136\u800c\u9019\u4e9b\u65b9\u6cd5\u53ea\u80fd\u6355\u6349\u53cd\u61c9\u958b\u59cb\u6216\u7d50\u675f\u7684\u55ae\u4e00\u77ac\u9593\uff0c\u7121\u6cd5\u9032\u4e00\u6b65\u89c0\u5bdf\u53cd\u61c9\u904e\u7a0b\u8207\u89f8\u767c\u6a5f\u5236\u3002<\/p>\n<p>\u672c\u6b21\u7814\u7a76\u5718\u968a\u5229\u7528 X \u5c04\u7dda\u81ea\u7531\u96fb\u5b50\u96f7\u5c04\uff08X-ray free electron laser, XFEL\uff09\u6280\u8853\uff0c\u5728\u6975\u77ed\uff08\u4e00\u767e\u5104\u5206\u4e4b\u4e00\u5230\u4e94\u5343\u5206\u4e4b\u4e00\u79d2\uff09\u7684\u6642\u9593\u5167\uff0c\u70ba DNA \u5149\u89e3\u9176\u50ac\u5316\u904e\u7a0b\u7684\u591a\u500b\u53cd\u61c9\u4e2d\u9593\u9ad4\u7d50\u69cb\u62cd\u4e86 18 \u5f35\u7167\u7247\u3002\u900f\u904e\u9019\u4e9b\u7167\u7247\uff0c\u53ef\u9032\u4e00\u6b65\u63ed\u793a DNA \u4fee\u5fa9\u5316\u5b78\u53cd\u61c9\u7684\u52d5\u614b\u904e\u7a0b\uff0c\u5982\u9175\u7d20\u6b98\u57fa\u5982\u4f55\u4fc3\u4f7f\u5316\u5b78\u53cd\u61c9\u3001\u9175\u7d20\u5728\u4fee\u5fa9\u5f8c\u5982\u4f55\u56de\u5230\u57fa\u614b\uff0c\u4ee5\u53ca\u6700\u7d42\u4fee\u5fa9\u7684DNA \u5982\u4f55\u6062\u5fa9\u5176\u6a19\u6e96\u7d50\u69cb\u7b49\u904e\u7a0b\u3002<\/p>\n<p><strong>\u958b\u555f\u9175\u7d20\u5b78\u65b0\u6642\u4ee3<\/strong><\/p>\n<p>\u8521\u660e\u9053\u9662\u58eb\u6307\u51fa\uff0c\u9019\u9805\u7814\u7a76\u4fc3\u9032\u7d50\u69cb\u751f\u7269\u5b78\u7684\u524d\u7aef\u767c\u5c55\uff0c\u4ea6\u958b\u555f\u4e86\u9175\u7d20\u5b78\u7684\u65b0\u6642\u4ee3\u2500\u53ef\u76f4\u63a5\u4ee5\u539f\u5b50\u89e3\u6790\u5ea6\u89c0\u5bdf\u9175\u7d20\u53cd\u61c9\u7684\u5b8c\u6574\u904e\u7a0b\u3002\u900f\u904e XFEL \u6280\u8853\uff0c\u53ef\u6aa2\u8996\u9175\u7d20\u7684\u53cd\u61c9\u4e2d\u9593\u9ad4\u7d50\u69cb\u7684\u5168\u8c8c\uff0c\u9032\u800c\u63d0\u4f9b\u5f8c\u7e8c\u61c9\u7528\u6a5f\u6703\uff0c\u4f8b\u5982\u65b0\u85e5\u7269\u958b\u767c\u7684\u6f5b\u5728\u65b0\u9776\u9ede\u3002\u7576\u9019\u9805\u6280\u8853\u8b8a\u5f97\u66f4\u70ba\u5ee3\u6cdb\u61c9\u7528\u6642\uff0c\u5c07\u5177\u6709\u7121\u9650\u7684\u61c9\u7528\u6f5b\u529b\u3002<\/p>\n<p>\u672c\u7bc7\u8ad6\u6587\u5171\u6709 69 \u4f4d\u5171\u540c\u4f5c\u8005\uff0c\u5206\u5225\u4f86\u81ea\u4e16\u754c\u5404\u5730\u7684 17 \u500b\u7814\u7a76\u6a5f\u69cb\u3002\u4e3b\u8981\u9818\u5c0e\u8005\u662f\u672c\u9662\u7684\u9175\u7d20\u5b78\u5bb6\u8521\u660e\u9053\u9662\u58eb\uff0c\u8521\u9662\u58eb\u85c9\u7531\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\uff08Taiwan Protein Project of Academia Sinica, TPP\uff09\u6574\u5408\u570b\u5167\u5916\u6280\u8853\u53ca\u9802\u5c16\u7814\u7a76\u4eba\u54e1\u3002\u5176\u4ed6\u53c3\u8207\u8005\u5305\u62ec\u5fb7\u570b\u99ac\u723e\u5821\u8153\u529b\u5927\u5b78\u7684\u7d50\u69cb\u751f\u7269\u5b78\u5bb6\u62c9\u723e\u65af &#8211; \u5967\u5229\u5f17 \u2027 \u827e\u68ee\uff08Lars-Oliver Essen\uff09\u6559\u6388\uff1b\u7b2c\u4e00\u4f5c\u8005\u99ac\u5de6\u4ef2\uff08Manuel Maestre-Reyna\uff09\u535a\u58eb\uff08\u672c\u9662\u524d\u535a\u58eb\u5f8c\u53ca\u5ba2\u5ea7\u5b78\u8005\uff0c\u76ee\u524d\u4efb\u6559\u65bc\u570b\u7acb\u81fa\u7063\u5927\u5b78)\uff1b\u5225\u6240\u7fa9\u9686\uff08Yoshitaka Bessho\uff09\u535a\u58eb\uff08\u672c\u9662\u524d\u5ba2\u5ea7\u6559\u6388\uff0c\u76ee\u524d\u4efb\u8077\u65bc\u65e5\u672c\u6771\u4eac\u5927\u5b78\uff09\uff1b\u6cd5\u570b CNRS \u683c\u52d2\u8afe\u5e03\u723e\u963f\u723e\u5351\u65af\u5927\u5b78\u7684\u7814\u7a76\u4e3b\u4efb\u5b89\u6258\u842c \u2027 \u7f85\u63da\u7279\uff08Antoine Royant\uff09\u535a\u58eb\uff1b\u4ee5\u53ca\u65e5\u672c\u5927\u962a\u5927\u5b78\u7684\u5c71\u672c\u6df3\u5e73\uff08Junpei Yamamoto\uff09\u535a\u58eb\u3002<\/p>\n<p>\u9019\u9805\u7814\u7a76\u7684\u7d93\u8cbb\u7531\u672c\u9662\u57f7\u884c\u6211\u570b\u653f\u5e9c\u79d1\u6280\u767c\u5c55\u8a08\u756b\u9805\u4e0b\u4e4b\u300c\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u300d\u652f\u61c9\uff0cXFEL \u7814\u7a76\u5247\u5728\u65e5\u672c SACLA \u548c\u745e\u58eb SwissFEL \u9032\u884c\uff0c\u662f\u81fa\u7063\u86cb\u767d\u8cea\u8a08\u756b\u7684\u91cd\u8981\u6210\u679c\u3002<\/p>\n<p>\u8ad6\u6587\u9023\u7d50\uff1a<a href=\"https:\/www.science.org\/doi\/10.1126\/science.add7795\" rel=\"noopener\" target=\"_blank\">https:\/www.science.org\/doi\/10.1126\/science.add7795<\/a><br \/>\n\u5f71\u7247\u9023\u7d50\uff1a<a href=\"https:\/reurl.cc\/blvA5y\" rel=\"noopener\" target=\"_blank\">https:\/reurl.cc\/blvA5y<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA \u640d\u50b7\u6709\u591a\u7a2e\u985e\u578b\uff0c\u662f\u5c0e\u81f4\u764c\u75c7\u6216\u907a\u50b3\u6027\u75be\u75c5\u7684\u81f4\u75c5\u539f\u56e0\u4e4b\u4e00\uff0c\u751f\u7269\u9ad4\u5c0d\u6b64\u9032\u5316\u51fa\u4e0d\u540c\u7684\u4fee\u5fa9\u6a5f\u5236\uff0c\u4f46\u5176\u4fee\u5fa9\u904e\u7a0b\u4ecd\u662f [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":33366,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[4],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/33364"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=33364"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/33364\/revisions"}],"predecessor-version":[{"id":33367,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/33364\/revisions\/33367"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/33366"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=33364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=33364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=33364"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}