{"id":32991,"date":"2023-11-16T00:19:51","date_gmt":"2023-11-15T16:19:51","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=32991"},"modified":"2023-11-16T06:24:38","modified_gmt":"2023-11-15T22:24:38","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e7%97%85%e6%af%92-rna-%e4%b8%8a%e7%9a%84%e5%b0%8f%e5%88%86%e5%ad%90%e4%bf%ae%e9%a3%be","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/32991\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u75c5\u6bd2 RNA \u4e0a\u7684\u5c0f\u5206\u5b50\u4fee\u98fe"},"content":{"rendered":"
\n
\n\t\t\t\t\t\"\u8521\u677e\u667a\u52a9\u7814\u7a76\u54e1\uff08\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\uff09\"\n\t\t\t\t<\/div>\n
\n\t\t\t\t\t\u8521\u677e\u667a\u52a9\u7814\u7a76\u54e1 2014 \u5e74\u7562\u696d\u65bc\u7f8e\u570b\u8cd3\u5dde\u5927\u5b78\u7d30\u80de\u8207\u5206\u5b50\u751f\u7269\u5b78\u5b78\u7a0b\uff0c\u96a8\u5f8c\u65bc\u675c\u514b\u5927\u5b78\u64d4\u4efb\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u81f3 2021 \u5e74\u65bc\u672c\u9662\u751f\u91ab\u6240\u4efb\u8077\u3002\u535a\u73ed\u6642\u671f\u63a2\u7d22 EB \u75c5\u6bd2\u7684\u8868\u89c0\u907a\u50b3\u5b78\u8abf\u63a7\uff0c\u535a\u5f8c\u4ee5\u4f86\u7814\u7a76 HIV-1\u3001A \u578b\u6d41\u611f\u3001\u8207 SV40 \u4e4b\u8868\u89c0\u8f49\u9304\u9ad4\u5b78\u8abf\u63a7\u3002\n\t\t\t\t<\/div>
<\/div><\/div>\n

 <\/p>\n

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\n <\/p>\n

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\u65e9\u671f\u767c\u73fe\u7684\u75c5\u6bd2 RNA \u4fee\u98fe<\/strong><\/p>\n

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\u75c5\u6bd2 RNA \u4fee\u98fe\u53ef\u589e\u5f37\u75c5\u6bd2\u7684\u57fa\u56e0\u8868\u73fe<\/strong><\/p>\n

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RNA \u7532\u57fa\u5316\u4fee\u98fe\u4fc3\u9032\u75c5\u6bd2\u8907\u88fd\u7684\u73fe\u8c61\uff0c\u5728 HIV-1 \u548c\u817a\u75c5\u6bd2\u4e2d\u5c24\u5176\u660e\u78ba\uff0c\u6709\u4fee\u98fe\u7684 HIV-1 RNA \u53ef\u4ee5\u5728\u5bbf\u4e3b\u7d30\u80de\u4e2d\u5b58\u6d3b\u6bd4\u8f03\u4e45\uff0c\u907f\u514d\u75c5\u6bd2 RNA \u5728\u5b8c\u6210\u4efb\u52d9\u524d\u5148\u88ab\u5bbf\u4e3b\u7d30\u80de\u88c2\u89e3\uff1b\u6b64\u5916 RNA \u53ef\u4ee5\u5728\u751f\u7522\u51fa\u4f86\u5f8c\u518d\u88ab\u526a\u63a5\uff08RNA splicing\uff09\uff0c\u4e0d\u540c\u7684\u526a\u63a5\u65b9\u5f0f\u8868\u73fe\u51fa\u4e0d\u540c\u7684\u86cb\u767d\u8cea\uff0c\u800c RNA \u7532\u57fa\u5316\u53ef\u4ee5\u8abf\u63a7 RNA \u7684\u526a\u63a5\uff0c\u4ee5\u78ba\u4fdd HIV-1 \u548c\u817a\u75c5\u6bd2\u8868\u73fe\u7684\u75c5\u6bd2\u86cb\u767d\u8cea\u7a2e\u985e\u6b63\u78ba\u3001\u6216\u5404\u7a2e\u985e\u8868\u73fe\u6bd4\u4f8b\u5408\u4e4e\u75c5\u6bd2\u7576\u4e0b\u7684\u9700\u6c42\u3002<\/p>\n

RNA \u4fee\u98fe\u53ef\u8abf\u63a7\u7d30\u80de\u7684\u6297\u75c5\u6bd2\u514d\u75ab<\/strong><\/p>\n

\u9664\u4e86\u8abf\u63a7\u75c5\u6bd2\u57fa\u56e0\u7684\u8868\u73fe\uff0cRNA \u4fee\u98fe\u4e5f\u53ef\u4ee5\u8abf\u63a7\u5bbf\u4e3b\u7d30\u80de\u7684\u6297\u75c5\u6bd2\u53cd\u61c9\u3002\u4eba\u985e\u5de8\u7d30\u80de\u75c5\u6bd2\uff08Human Cytomegalovirus, HCMV\uff09\u662f\u500b\u4e0d\u5e38\u807d\u5230\uff0c\u4f46\u53ef\u9020\u6210\u65b0\u751f\u5152\u807d\u529b\u56b4\u91cd\u53d7\u640d\u7684\u5e38\u898b\u75c5\u6bd2\u3002\u96d6\u7136\u4eba\u985e\u5de8\u7d30\u80de\u75c5\u6bd2\u7684 RNA \u4e0a\u627e\u4e0d\u5230\u7532\u57fa\u5316\u4fee\u98fe\uff0c\u4f46\u9019\u75c5\u6bd2\u53ef\u4ee5\u589e\u5f37\u5bbf\u4e3b\u7d30\u80de\u5167\u7684 RNA \u7532\u57fa\u5316\u6a5f\u5236\uff0c\u4f7f\u7d30\u80de\u5167\u7684\u91cd\u8981\u6297\u75c5\u6bd2\u57fa\u56e0\u5e72\u64fe\u7d20 \u03b2\uff08interferon \u03b2\uff09\u7684 RNA \u88ab\u7532\u57fa\u5316\u3002\u6709\u8da3\u7684\u662f\u5bbf\u4e3b\u7d30\u80de\u7684 RNA \u88ab\u7532\u57fa\u5316\u53cd\u800c\u53ef\u4ee5\u4fc3\u9032\u5176\u88c2\u89e3\uff0c\u81f4\u4f7f\u9019\u75c5\u6bd2\u611f\u67d3\u904e\u7a0b\u4e2d\uff0c\u501a\u8cf4\u5e72\u64fe\u7d20 \u03b2 \u7684\u6297\u75c5\u6bd2\u6a5f\u5236\u88ab\u524a\u5f31\uff0c\u4f7f\u75c5\u6bd2\u80fd\u5920\u66f4\u6709\u6548\u7387\u7684\u8907\u88fd\u3002<\/p>\n

2005 \u5e74 Kariko & Weissman \u767c\u73fe\u4eba\u5de5\u5408\u6210\u7684 RNA \u82e5\u76f4\u63a5\u9001\u9032\u7d30\u80de\u88e1\uff0c\u6703\u8a98\u767c\u7522\u751f\u56b4\u91cd\u7684\u514d\u75ab\u53cd\u61c9\u800c\u9020\u6210\u7d30\u80de\u6b7b\u4ea1\uff0c\u82e5\u52a0\u5165\u7532\u57fa\u5316\u4fee\u98fe\u5247\u53ef\u4ee5\u907f\u514d\u4eba\u5de5 RNA \u88ab\u7d30\u80de\u5075\u6e2c\u70ba\u5916\u4f86\u7269\u7522\u751f\u514d\u75ab\u53cd\u61c9\uff0c\u5728\u5404\u7a2e\u4fee\u98fe\u4e2d\u4ee5\u7532\u57fa\u5316\u5047\u5c3f\u5627\u5576\u6838\u82f7\uff08N1<\/sup>-methylpseudouridine, m1\u03c8\uff09\u7684\u6548\u679c\u6700\u597d\u3002\u6b64\u767c\u73fe\u4f7f\u4eba\u5011\u7406\u89e3\u5230\u52a0\u5165\u7532\u57fa\u5316\u4fee\u98fe\u5373\u53ef\u53bb\u9664\u4eba\u5de5\u5408\u6210 RNA \u5c0d\u7d30\u80de\u7684\u6bd2\u6027\uff0c\u800c\u61c9\u7528\u6b64\u6280\u8853\u7684 RNA \u75ab\u82d7\u6210\u70ba\u4e86\u5168\u4e16\u754c COVID-19 \u80ba\u708e\u75ab\u60c5\u7684\u89e3\u65b9\uff0c\u56e0\u6b64\u4eca\u5e74\uff082023\uff09Kariko & Weissman \u7372\u9812\u4e86\u8afe\u8c9d\u723e\u91ab\u5b78\u734e\u3002<\/p>\n

\u65e2\u7136 RNA \u4fee\u98fe\u53ef\u4ee5\u9632\u6b62\u300c\u5916\u4f86\u300dRNA \u88ab\u7d30\u80de\u767c\u73fe\u3001\u89f8\u52d5\u514d\u75ab\u53cd\u61c9\uff0c\u90a3\u9ebc\u75c5\u6bd2\u662f\u5426\u4e5f\u6703\u4f7f\u7528\u9019\u500b\u65b9\u6cd5\u5077\u5077\u7684\u6df7\u9032\u7d30\u80de\u5462\uff1f\u7684\u78ba\u8fd1\u5e74\u4f86\u591a\u7a2e\u5305\u88f9 RNA \u7684\u75c5\u6bd2\u7686\u88ab\u767c\u73fe\u63a1\u7528\u9019\u7a2e\u65b9\u5f0f\u907f\u514d\u89f8\u52d5\u5bbf\u4e3b\u7d30\u80de\u7684\u6297\u75c5\u6bd2\u514d\u75ab\u53cd\u61c9\uff0c\u5305\u542b\u4eba\u985e\u9593\u8cea\u80ba\u708e\u75c5\u6bd2\uff08Human metapneumovirus, HMPV\uff09\u3001\u547c\u5438\u9053\u878d\u5408\u75c5\u6bd2\uff08Respiratory syncytial virus, RSV\uff09\u3001\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\uff08SARSCoV-2\uff09\u7686\u88ab\u767c\u73fe\u5176\u75c5\u6bd2 RNA \u4e0a\u7684\u7532\u57fa\u5316\u4fee\u98fe\u53ef\u4ee5\u6e1b\u5c11\u75c5\u6bd2 RNA \u89f8\u52d5\u7d30\u80de\u5075\u6e2c\u6a5f\u5236\uff0c\u9032\u800c\u6e1b\u5c11\u6297\u75c5\u6bd2\u7269\u8cea\u5e72\u64fe\u7d20\u7684\u7522\u751f\u3002<\/p>\n

\"\u3010\u5c08\u6b04\u3011\u75c5\u6bd2

\u25b2\u75c5\u6bd2 RNA \u7532\u57fa\u5316\u4fee\u98fe\u7684\u591a\u6a23\u529f\u80fd<\/p><\/div>
\n <\/p>\n

\u672a\u4f86\u5c55\u671b\u8207\u75c5\u6bd2 RNA \u4fee\u98fe\u7684\u61c9\u7528<\/strong><\/p>\n

\u7d9c\u5408\u4ee5\u4e0a\u7814\u7a76\uff0c\u591a\u6578\u75c5\u6bd2\u632a\u7528\u4e86 RNA \u4fee\u98fe\u9019\u500b\u7d30\u80de\u7684\u57fa\u56e0\u8abf\u63a7\u6a5f\u5236\uff0c\u4f86\u4fc3\u9032\u75c5\u6bd2\u611f\u67d3\u6210\u529f\u7387\u3001\u57fa\u56e0\u8868\u73fe\u3001\u548c\u8907\u88fd\u6548\u7387\u3002\u56e0\u70ba RNA \u4fee\u98fe\u5c0d\u591a\u6a23\u5316\u7684\u75c5\u6bd2\u8907\u88fd\u6709\u91cd\u8981\u7684\u4fc3\u9032\u6548\u679c\uff0c\u56e0\u6b64\u6211\u5011\u8a8d\u70ba\u6709\u671b\u91dd\u5c0d\u9019\u500b\u6a5f\u5236\u4f86\u7814\u767c\u65b0\u7684\u6297\u75c5\u6bd2\u85e5\u7269\u3002\u8fd1\u5e7e\u5e74\u4f86\u6709\u5927\u91cf\u7814\u7a76\u767c\u73fe RNA \u4fee\u98fe\u4e5f\u5728\u764c\u7d30\u80de\u767c\u5c55\u7684\u904e\u7a0b\u4e2d\u4f54\u6709\u91cd\u8981\u89d2\u8272\uff0c\u56e0\u6b64\u5df2\u6709\u591a\u500b\u65b0\u5275\u516c\u53f8\u6b63\u5728\u958b\u767c\u53ef\u6291\u5236 RNA \u7532\u57fa\u5316\u4fee\u98fe\u7684\u65b0\u85e5\u4ee5\u4f5c\u70ba\u6297\u764c\u85e5\u3002\u6709\u8da3\u7684\u662f\uff0c\u5176\u4e2d\u6700\u65e9\u767c\u8868\u7684 RNA \u7532\u57fa\u5316\u6291\u5236\u5291\uff0c\u5728 2021 \u5e74\u88ab\u82f1\u570b\u65b0\u5275\u516c\u53f8\u300c\u98a8\u66b4\u88fd\u85e5\uff08Storm Theraputics\uff09\u300d\u4ee5\u6297\u767d\u8840\u75c5\u85e5\uff08acute myeloid leukemia, AML\uff09\u7684\u540d\u7fa9\u767c\u8868\u65bc\u671f\u520a\u4ee5\u5f8c\uff0c\u4e5f\u7dca\u63a5\u7684\u88ab\u7d10\u7d04\u5927\u5b78\u5718\u968a\u767c\u73fe\u5728\u57f9\u990a\u76bf\u4e2d\u53ef\u4ee5\u6291\u5236\u65b0\u51a0\u80ba\u708e\u75c5\u6bd2\u548c\u5c0f\u611f\u5192\u51a0\u72c0\u75c5\u6bd2\uff08HCoVOC43\uff09\u7684\u8907\u88fd\u3002<\/p>\n

\u96d6\u7136\u9019\u4e9b\u6280\u8853\u9084\u5728\u958b\u767c\u968e\u6bb5\uff0c\u5291\u91cf\u8207\u5b89\u5168\u6027\u9700\u9032\u4e00\u6b65\u6e2c\u8a66\u8207\u8a55\u4f30\u7684\u65b0\u85e5\uff0c\u4f46\u76f8\u4fe1\u672a\u4f86\u6703\u6709\u8d8a\u4f86\u8d8a\u591a RNA \u4fee\u98fe\u6291\u5236\u5291\u88ab\u958b\u767c\u51fa\u4f86\uff0c\u5c46\u6642\u4e5f\u6703\u66f4\u52a0\u4e86\u89e3\u662f\u5426\u9019\u985e\u85e5\u7269\u53ef\u7528\u70ba\u6291\u5236\u591a\u7a2e\u75c5\u6bd2\u8907\u88fd\u7684\u5ee3\u6548\u6027\u6297\u75c5\u6bd2\u85e5\u3002COVID-19 \u75ab\u60c5\u518d\u6b21\u986f\u793a\uff0c\u6bcf\u9694\u5e7e\u5e74\u5c31\u6703\u6709\u672a\u77e5\u7684\u65b0\u8208\u50b3\u67d3\u75be\u75c5\u9032\u5165\u4eba\u7fa4\uff0c\u800c\u4e14\u4eba\u985e\u4e26\u4e0d\u662f\u6bcf\u6b21\u90fd\u6703\u50cf SARS \u75ab\u60c5\u90a3\u6a23\u5e78\u904b\u7684\u53ef\u4ee5\u7b49\u5b83\u81ea\u7136\u6d88\u5931\u3002\u56e0\u6b64\u4eba\u5011\u9700\u8981\u5132\u5099\u591a\u7a2e\u5ee3\u6548\u6027\u6297\u75c5\u6bd2\u85e5\uff0c\u4ee5\u5099\u5feb\u901f\u5c0d\u6297\u672a\u4f86\u51fa\u73fe\u7684\u65b0\u75c5\u6bd2\u6240\u9700\uff0c\u800c\u6211\u5011\u8a8d\u70ba RNA \u4fee\u98fe\u662f\u4e00\u500b\u53ef\u671b\u6eff\u8db3\u6b64\u9700\u6c42\u7684\u6297\u75c5\u6bd2\u6a19\u7684\u6a5f\u5236\u3002
\n <\/p>\n

\n

\u5ef6\u4f38\u95b1\u8b80<\/strong><\/p>\n

Tsai K, Cullen BR. Epigenetic and epitranscriptomic regulation of viral replication. Nat Rev Microbiol. 2020 Oct;18(10):559-570. doi: 10.1038\/s41579-020-0382-3. Epub 2020 Jun 12. PMID: 32533130; PMCID: PMC7291935.<\/p>\n

Courtney DG. Post-Transcriptional Regulation of Viral RNA through Epitranscriptional Modification. Cells. 2021 May 7;10(5):1129. doi: 10.3390\/cells10051129. PMID: 34066974; PMCID: PMC8151693.<\/p>\n

Nance KD, Meier JL. Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines. ACS Cent Sci. 2021 May 26;7(5):748-756. doi: 10.1021\/acscentsci.1c00197. Epub 2021 Apr 6. PMID: 34075344; PMCID: PMC8043204.<\/p>\n","protected":false},"excerpt":{"rendered":"

  \u75c5\u6bd2\u662f\u4ec0\u9ebc\u6a23\u7684\u5b58\u5728\uff1f \u75c5\u6bd2\uff0c\u662f\u500b\u5927\u5bb6\u8033\u719f\u80fd\u8a73\u7684\u5fae\u5c0f\u75c5\u539f\u9ad4\u3002\u6211\u5011\u66ab\u4e14\u8df3\u812b\u5c0d\u5176\u6240\u9020\u6210\u50b3\u67d3\u6027\u75be\u75c5\u7684\u6050\u61fc […]<\/p>\n","protected":false},"author":1,"featured_media":33158,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[991,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32991"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=32991"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32991\/revisions"}],"predecessor-version":[{"id":33157,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32991\/revisions\/33157"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/33158"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=32991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=32991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=32991"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}