{"id":32392,"date":"2023-09-07T00:12:53","date_gmt":"2023-09-06T16:12:53","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=32392"},"modified":"2023-09-07T00:05:24","modified_gmt":"2023-09-06T16:05:24","slug":"%e4%ba%ba%e5%b7%a5%e6%99%ba%e6%85%a7%e5%b7%a5%e5%85%b7%e5%8a%a0%e9%80%9f%e8%9b%8b%e7%99%bd%e8%b3%aa%e8%a8%ad%e8%a8%88%e8%88%87%e6%8f%90%e5%8d%87%e9%85%b6%e6%b4%bb%e6%80%a7","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/32392\/","title":{"rendered":"\u4eba\u5de5\u667a\u6167\u5de5\u5177\u52a0\u901f\u86cb\u767d\u8cea\u8a2d\u8a08\u8207\u63d0\u5347\u9176\u6d3b\u6027"},"content":{"rendered":"<p>\u5f37\u5316\u86cb\u767d\u8cea\u9175\u7d20\u7684\u6d3b\u6027\u662f\u751f\u7269\u79d1\u6280\u7814\u7a76\u7684\u56b4\u5cfb\u6311\u6230\uff0c\u50b3\u7d71\u65b9\u6cd5\u4ef0\u8cf4\u5927\u898f\u6a21\u7684\u7be9\u9078\u5e73\u53f0\u548c\u751f\u5316\u6d3b\u6027\u9a57\u8b49\u3002\u6709\u9451\u65bc\u6b64\uff0c\u672c\u9662\u751f\u7269\u5316\u5b78\u7814\u7a76\u6240\u5433\u6606\u5cef\u52a9\u7814\u7a76\u54e1\u7814\u7a76\u5718\u968a\u7387\u5148\u5957\u7528\u5148\u9032\u7684\u4eba\u5de5\u667a\u6167\u6df1\u5ea6\u5b78\u7fd2\u5de5\u5177 ProteinMPNN \u52a0\u901f\u86cb\u767d\u8cea\u5de5\u7a0b\u7684\u4f5c\u696d\u6d41\u7a0b\u3002\u8a72\u5718\u968a\u4f7f\u7528\u6cdb\u7d20\u70ba\u4f8b\u5b50\uff0c\u901a\u904e ProteinMPNN \u8a08\u7b97\u4e26\u91cd\u65b0\u8a2d\u8a08\u6210\u4e00\u7a2e\u91dd\u5c0d Rsp5 E3 \u9023\u63a5\u9176\u7684\u6cdb\u7d20\u8b8a\u7a2e\u3002\u6b64\u8b8a\u7a2e\u662f Rsp5 \u5c08\u5c6c\u7684\u6709\u6548\u8b8a\u69cb\u6d3b\u5291\uff08allosteric activator\uff09\uff0c\u5be6\u9a57\u5f9e\u8a2d\u8a08\u5230\u529f\u80fd\u9a57\u8b49\u50c5\u5728\u77ed\u77ed\u4e09\u500b\u6708\u5167\u5b8c\u6210\uff0c\u4e14\u7121\u9700\u4efb\u4f55\u4eba\u5de5\u4fee\u6b63\u8a2d\u8a08\u5167\u5bb9\uff0c\u9019\u4e00\u91cc\u7a0b\u7891\u9810\u793a\u4eba\u5de5\u667a\u6167\u9a45\u52d5\u86cb\u767d\u8cea\u8a2d\u8a08\u7684\u65b0\u6642\u4ee3\u5230\u4f86\u3002\u6b64\u7814\u7a76\u6210\u679c\u5df2\u65bc\u672c\uff08112\uff09\u5e74 8 \u6708\u767c\u8868\u5728\u300a\u7f8e\u570b\u5316\u5b78\u5b78\u6703\u5408\u6210\u751f\u7269\u5b78\u5c08\u520a\u300b\uff08<em>ACS Synthetic Biology<\/em>\uff09\u3002<\/p>\n<p>\u8ad6\u6587\u5168\u6587\uff1a <a href=\"https:\/pubs.acs.org\/doi\/10.1021\/acssynbio.3c00042\" rel=\"noopener\" target=\"_blank\">https:\/pubs.acs.org\/doi\/10.1021\/acssynbio.3c00042<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/09\/3-2.jpg\" alt=\"\u4eba\u5de5\u667a\u6167\u5de5\u5177\u52a0\u901f\u86cb\u767d\u8cea\u8a2d\u8a08\u8207\u63d0\u5347\u9176\u6d3b\u6027\" width=\"1800\" height=\"1202\" class=\"aligncenter size-full wp-image-32393\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/09\/3-2.jpg 1800w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/09\/3-2-300x200.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/09\/3-2-1024x684.jpg 1024w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/09\/3-2-768x513.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/09\/3-2-1536x1026.jpg 1536w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/09\/3-2-1080x721.jpg 1080w\" sizes=\"(max-width: 1800px) 100vw, 1800px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f37\u5316\u86cb\u767d\u8cea\u9175\u7d20\u7684\u6d3b\u6027\u662f\u751f\u7269\u79d1\u6280\u7814\u7a76\u7684\u56b4\u5cfb\u6311\u6230\uff0c\u50b3\u7d71\u65b9\u6cd5\u4ef0\u8cf4\u5927\u898f\u6a21\u7684\u7be9\u9078\u5e73\u53f0\u548c\u751f\u5316\u6d3b\u6027\u9a57\u8b49\u3002\u6709\u9451\u65bc\u6b64\uff0c\u672c\u9662\u751f\u7269\u5316 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":32394,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32392"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=32392"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32392\/revisions"}],"predecessor-version":[{"id":32424,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32392\/revisions\/32424"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/32394"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=32392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=32392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=32392"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}