{"id":32221,"date":"2023-08-24T00:10:05","date_gmt":"2023-08-23T16:10:05","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=32221"},"modified":"2023-08-29T10:13:42","modified_gmt":"2023-08-29T02:13:42","slug":"%e3%80%90%e5%b0%88%e6%ac%84%e3%80%91%e8%a7%a3%e9%8e%96%e7%94%9f%e5%91%bd%e6%a9%9f%e5%99%a8%e7%9a%84%e5%a5%a7%e7%a7%98%ef%bc%9a%e6%8e%a2%e7%b4%a2%e5%92%8c%e9%86%a3%e9%ab%94%e5%8f%8a%e6%9b%b4%e9%81%a0","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/32221\/","title":{"rendered":"\u3010\u5c08\u6b04\u3011\u89e3\u9396\u751f\u547d\u6a5f\u5668\u7684\u5967\u79d8\uff1a\u63a2\u7d22\u6838\u91a3\u9ad4\u53ca\u66f4\u9060\u7684\u672a\u4f86\u2014\u2014Venki Ramakrishnan \u6f14\u8b1b\u7d00\u5be6"},"content":{"rendered":"

\u300c\u4e2d\u592e\u7814\u7a76\u9662\u8b1b\u5ea7\u300d\u65bc\u672c\uff082023\uff09\u5e74 8 \u6708\u9080\u8acb\u82f1\u570b\u528d\u6a4b\u5206\u5b50\u751f\u7269\u5b78\u5be6\u9a57\u5ba4\uff08The Medical Research Council Laboratory of Molecular Biology\uff09\u7684\u6587\u5361\uff0e\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\uff08Venki Ramakrishnan\uff09\u535a\u58eb\u81f3\u672c\u9662\u6f14\u8b1b\u3002\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u65bc\u5370\u5ea6\u7684\u5df4\u7f85\u9054\u5927\u5b78\uff08The Maharaja Sayajirao University of Baroda\uff09\u5b78\u7fd2\u7269\u7406\u5b78\uff0c\u5f8c\u4f86\u5728\u7f8e\u570b\u4fc4\u4ea5\u4fc4\u5927\u5b78\uff08Ohio University\uff09\u53d6\u5f97\u7269\u7406\u5b78\u535a\u58eb\u5b78\u4f4d\u3002\u96a8\u5f8c\u8f49\u5411\u751f\u7269\u5b78\u9818\u57df\uff0c\u65bc\u8036\u9b6f\u5927\u5b78\uff08Yale University\uff09\u548c\u82f1\u570b\u528d\u6a4b\u5206\u5b50\u751f\u7269\u5b78\u5be6\u9a57\u5ba4\u7b49\u77e5\u540d\u6a5f\u69cb\u9032\u884c\u7814\u7a76\uff0c\u4ee5\u5176\u5728\u6838\u7cd6\u9ad4\u7d50\u69cb\u9818\u57df\u4e4b\u5de5\u4f5c\u800c\u805e\u540d\uff0c\u4e26\u65bc 2009 \u5e74\u69ae\u7372\u8afe\u8c9d\u723e\u5316\u5b78\u734e\u3002<\/p>\n

\"\u3010\u5c08\u6b04\u3011\u89e3\u9396\u751f\u547d\u6a5f\u5668\u7684\u5967\u79d8\uff1a\u63a2\u7d22\u6838\u91a3\u9ad4\u53ca\u66f4\u9060\u7684\u672a\u4f86\u2014\u2014Venki<\/p>\n

\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u65bc\u6f14\u8b1b\u4e2d\u5206\u4eab\u4ed6\u8f49\u63db\u5230\u751f\u7269\u5b78\u9818\u57df\u9032\u884c\u7814\u7a76\u7684\u5fc3\u8def\u6b77\u7a0b\u3002\u5728\u4ed6\u5b8c\u6210\u535a\u58eb\u5b78\u4f4d\u6642\uff0c\u7576\u6642\u7684\u751f\u7269\u5b78\u9818\u57df\u6b63\u8655\u65bc\u84ec\u52c3\u767c\u5c55\u7684\u968e\u6bb5\uff0c\u6642\u5e38\u6709\u632f\u596e\u4eba\u5fc3\u7684\u91cd\u5927\u767c\u73fe\uff0c\u52a0\u4e4b\u5df2\u6709\u4e0d\u5c11\u7269\u7406\u5b78\u5bb6\u5982\ufe30\u5f17\u6717\u897f\u65af\uff0e\u514b\u91cc\u514b\uff08Francis Crick\uff09\u548c\u99ac\u514b\u65af\uff0e\u4f69\u9b6f\u8328\uff08Max Perutz\uff09\u7b49\u4eba\uff0c\u8f49\u8eab\u6295\u5165\u5230\u751f\u7269\u5b78\u9032\u884c\u7814\u7a76\u4e26\u53d6\u5f97\u6539\u8b8a\u4e16\u754c\u89c0\u9ede\u7684\u8c50\u78a9\u6210\u679c\uff0c\u4fc3\u4f7f\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u5728\u5256\u6790\u81ea\u6211\u7814\u7a76\u8208\u8da3\u8207\u5c0d\u672a\u4f86\u7684\u60f3\u50cf\u5f8c\uff0c\u6bc5\u7136\u6c7a\u7136\u5730\u6295\u5165\u751f\u7269\u5b78\u7684\u7814\u7a76\u3002\u800c\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u5c0d\u795e\u79d8\u7684\u6838\u7cd6\u9ad4\u4e16\u754c\u7684\u63a2\u7d22\u4e4b\u65c5\u59cb\u65bc\u95b1\u8b80\u5230\u4e00\u7bc7\u520a\u767b\u5728\u300a\u79d1\u5b78\u4eba\u300b\uff08Scientific American<\/em>\uff09\u96dc\u8a8c\u7684\u6587\u7ae0\u2014\u2014\u3008\u6838\u7cd6\u9ad4\u7684\u4e2d\u5b50\u6563\u5c04\u7814\u7a76\uff08Neutron-scattering Studies of the Ribosome\uff09\u3009\uff0c\u9019\u6a23\u7684\u5076\u7136\u4e5f\u51f8\u986f\u4e86\u79d1\u5b78\u63a2\u7d22\u4e2d\u7684\u4e0d\u53ef\u9810\u6e2c\u6027\u3002<\/p>\n

\u7576\u6642\u89e3\u6790\u6838\u7cd6\u9ad4\u7d50\u69cb\u7684\u4e3b\u8981\u65b9\u6cd5\u6709\u8cf4\u65bc X \u5c04\u7dda\u7d50\u6676\u5b78\uff08X-ray crystallography\uff09\u3002\u9f90\u5927\u7684\u6838\u7cd6\u9ad4\u5148\u88ab\u62c6\u5206\u6210\u8f03\u5c0f\u7684\u86cb\u767d\u6b21\u55ae\u5143\uff08subunit\uff09\uff0c\u5c07\u4e4b\u7d14\u5316\u4e26\u57f9\u990a\u51fa\u86cb\u767d\u6676\u9ad4\u5f8c\uff0c\u5229\u7528\u540c\u6b65\u52a0\u901f\u5668\uff08synchrotron\uff09\u7522\u751f\u7684 X \u5c04\u7dda\u5c0d\u86cb\u767d\u6676\u9ad4\u9032\u884c\u7e5e\u5c04\u5be6\u9a57\u3002\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u7684\u5718\u968a\u4f7f\u7528\u7570\u5e38\u6563\u5c04\uff08anomalous scattering\uff09\u5be6\u9a57\u7372\u53d6\u5efa\u69cb\u4e09\u7dad\u86cb\u767d\u7d50\u69cb\u6240\u9700\u7684\u76f8\u4f4d\uff08phase\uff09\u8cc7\u8a0a\uff0c\u9032\u800c\u9996\u5ea6\u6210\u529f\u89e3\u6790\u51fa\u55dc\u71b1\u83cc\uff08Thermus thermophilus<\/em>\uff09\u7684 30S \u6b21\u55ae\u5143\u7684\u5206\u5b50\u7d50\u69cb\uff0c\u800c\u5f8c\u66f4\u89e3\u6790\u51fa\u5b8c\u6574\u7684\u6838\u7cd6\u9ad4\u7d50\u69cb\u3002\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u4e0d\u541d\u65bc\u4f7f\u7528\u65b0\u7684\u6280\u8853\u53bb\u63a2\u7d22\u7814\u7a76\u7684\u8b70\u984c\uff0c\u4e5f\u63d0\u9ede\u4e0d\u540c\u7684\u6280\u8853\u6f14\u9032\u5982\u4f55\u4fc3\u9032\u751f\u7269\u5b78\u7684\u767c\u5c55\uff0c\u50cf\u662f\u65e9\u671f\u540c\u6b65\u52a0\u901f\u5668\u7684\u5efa\u69cb\u3001\u8a08\u7b97\u6a5f\u8a08\u7b97\u80fd\u529b\u7684\u63d0\u5347\u8207\u76f8\u95dc\u8edf\u9ad4\u7684\u958b\u767c\uff0c\u90fd\u6709\u52a9\u65bc\u5176\u89e3\u958b\u6838\u7cd6\u9ad4\u904b\u4f5c\u7684\u5967\u79d8\u3002\u5728 2013 \u5e74\u5de6\u53f3\uff0c\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\uff08cryogenic electron microscopy\uff09\u9818\u57df\u767c\u751f\u4e86\u300c\u89e3\u6790\u5ea6\u9769\u547d\uff08resolution revolution\uff09\u300d\uff0c\u751f\u7269\u5de8\u5206\u5b50\u80fd\u4ee5\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\u7684\u6280\u8853\u91cd\u5efa\u51fa\u9054\u5230\u539f\u5b50\u7d1a\u89e3\u6790\u5ea6\u7684\u7d50\u69cb\u3002\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u4e5f\u64c1\u62b1\u65b0\u7684\u9769\u65b0\u6280\u8853\uff0c\u5c07\u4e3b\u8981\u7684\u7814\u7a76\u65b9\u6cd5\u7531 X \u5c04\u7dda\u7d50\u6676\u5b78\u79fb\u8f49\u81f3\u51b7\u51cd\u96fb\u5b50\u986f\u5fae\u93e1\uff0c\u4ee5\u7814\u7a76\u66f4\u70ba\u8907\u96dc\u7684\u771f\u6838\u751f\u7269\u8207\u7c92\u7dda\u9ad4\u5167\u7684\u8f49\u8b6f\u4f5c\u7528\u3002<\/p>\n

\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u65bc\u6f14\u8b1b\u904e\u7a0b\u4e2d\u4e5f\u5411\u807d\u773e\u4ecb\u7d39\u4e86\u99ac\u514b\u65af\uff0e\u4f69\u9b6f\u8328\u66fe\u63d0\u53ca\u7684\u300c\u56db\u500b G\u300d\u2014\u2014\u5728\u79d1\u5b78\u4e16\u754c\u4e2d\u6210\u9577\u8301\u58ef\u7684\u79d8\u8a23\u3002\u5176\u4e2d\uff0c\u300cGeld\uff08\u91d1\u9322\uff09\u300d\u4ee3\u8868\u652f\u6301\u7814\u7a76\u7684\u8cc7\u91d1\uff0c\u300cGeschick\uff08\u6280\u80fd\uff09\u300d\u5247\u662f\u900f\u904e\u7279\u6b8a\u57f9\u8a13\u7372\u5f97\u7684\u5c08\u696d\u77e5\u8b58\uff0c\u300cGeduld\uff08\u8010\u5fc3\uff09\u300d\u662f\u4e0d\u8981\u904e\u65e9\u653e\u68c4\u7684\u5fc3\u614b\uff0c\u800c\u300cGl\u00fcck\uff08\u904b\u6c23\uff09\u300d\u5247\u662f\u51a5\u51a5\u4e4b\u4e2d\u63a8\u52d5\u6211\u5011\u524d\u9032\u7684\u50ac\u5316\u5291\u3002\u6b63\u5982\u4ed6\u5de7\u5999\u5730\u5f62\u5bb9\uff0c\u9019\u56db\u500b\u652f\u67f1\u69cb\u6210\u4e86\u4e00\u500b\u6210\u529f\u79d1\u5b78\u4e8b\u696d\u7684\u57fa\u77f3\u3002<\/p>\n

\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u5c0d\u65bc\u9078\u64c7\u7814\u7a76\u4e3b\u984c\u7684\u6d1e\u898b\u4e5f\u4ee4\u521d\u51fa\u8305\u5eec\u7684\u79d1\u5b78\u5bb6\u5011\u7522\u751f\u5171\u9cf4\u3002\u4ed6\u5efa\u8b70\u81f4\u529b\u65bc\u6709\u8da3\u4e14\u5177\u5f71\u97ff\u529b\u7684\u554f\u984c\uff0c\u800c\u975e\u4e00\u5473\u8ffd\u6c42\u300c\u6d41\u884c\u300d\u7684\u984c\u76ee\u3002\u56e0\u70ba\u6709\u8da3\u800c\u80fd\u6301\u7e8c\u9ede\u71c3\u5c0d\u7814\u7a76\u7684\u71b1\u5ff1\uff1b\u56e0\u70ba\u5177\u5099\u5f71\u97ff\u529b\u800c\u80fd\u9a45\u52d5\u81ea\u5df1\u8a8d\u771f\u9762\u5c0d\u5de5\u4f5c\u7684\u6bcf\u4e00\u5929\u3002\u4ed6\u4e5f\u6307\u51fa\u9019\u500b\u554f\u984c\u672c\u8cea\u4e0a\u4e26\u7121\u6b63\u89e3\uff0c\u7136\u800c\u53ea\u8981\u4f9d\u64da\u300c\u8da3\u5473\u6027\u300d\u8207\u300c\u5f71\u97ff\u529b\u300d\u9019\u5169\u5927\u7279\u6027\u4f86\u5c0b\u627e\u7814\u7a76\u4e3b\u984c\uff0c\u5c31\u6709\u6a5f\u6703\u5ea6\u904e\u7cbe\u5f69\u7684\u79d1\u5b78\u751f\u6daf\u3002<\/p>\n

\u6700\u5f8c\uff0c\u5ed6\u4fca\u667a\u9662\u9577\u900f\u904e\u63d0\u554f\u5f15\u51fa\u4eba\u5de5\u667a\u80fd\uff08artificial intelligence\uff0c AI\uff09\u8207\u751f\u7269\u5b78\u7684\u4ea4\u532f\u3002\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u8a8d\u70ba AI \u6709\u671b\u91cd\u65b0\u5851\u9020\u751f\u7269\u5b78\u7814\u7a76\u7684\u683c\u5c40\uff0c\u5f9e\u63d0\u5347\u6578\u64da\u5206\u6790\u6548\u7387\u5230\u5354\u52a9\u79d1\u5b78\u5f71\u50cf\u5206\u6790\uff0cAI \u8207\u751f\u7269\u5b78\u7684\u6574\u5408\u5c07\u53e6\u95e2\u8e4a\u5f91\uff0c\u5927\u5e45\u52a0\u901f\u6211\u5011\u5c0d\u65bc\u751f\u7269\u8907\u96dc\u7cfb\u7d71\u7684\u638c\u63e1\u3002<\/p>\n

\u62c9\u99ac\u514b\u91cc\u5e0c\u5357\u535a\u58eb\u7684\u6f14\u8b1b\u6368\u68c4\u8271\u6f80\u7684\u79d1\u5b78\u8853\u8a9e\uff0c\u6df1\u5165\u6dfa\u51fa\u7684\u4ecb\u7d39\u4e86\u6838\u7cd6\u9ad4\u7684\u5967\u79d8\uff0c\u4e26\u5728\u904e\u7a0b\u4e2d\u5c55\u73fe\u4e00\u4f4d\u5353\u8d8a\u7684\u79d1\u5b78\u5bb6\u5c0d\u7814\u7a76\u7684\u7368\u5230\u898b\u89e3\u8207\u71b1\u60c5\uff0c\u540c\u6642\u4ecd\u4fdd\u6709\u6a02\u65bc\u5617\u8a66\u65b0\u79d1\u6280\u7684\u8d64\u5b50\u4e4b\u5fc3\u4ee5\u53ca\u5c0d\u672a\u4f86\u79d1\u5b78\u767c\u5c55\u7684\u61a7\u61ac\u3002\u5728\u9019\u8d9f\u975e\u51e1\u7684\u7814\u7a76\u4e4b\u65c5\u4e2d\uff0c\u6211\u5011\u770b\u898b\u79d1\u5b78\u8207\u9748\u611f\u7f8e\u597d\u7684\u9082\u9005\uff0c\u4e5f\u9ad4\u6703\u5230\u80fd\u5920\u751f\u800c\u70ba\u4eba\uff0c\u53e9\u554f\u69cb\u7bc9\u751f\u547d\u7684\u6a5f\u8f49\u4e26\u7aba\u63a2\u81ea\u7136\u7684\u5320\u5fc3\u7368\u904b\uff0c\u672c\u8eab\u5373\u662f\u4e00\u7a2e\u96e3\u80fd\u53ef\u8cb4\u7684\u6536\u7a6b\u3002<\/p>\n

\n

\u53c3\u8003\u8cc7\u6599<\/strong><\/p>\n

    \n
  1. \u300c\u6211\u7684\u6838\u7cd6\u9ad4\u5192\u96aa\u7d93\u6b77\u300d\uff0cDr. Venki Ramakrishnan\uff0c2023 \u5e74\u4e2d\u592e\u7814\u7a76\u9662\u8b1b\u5ea7<\/li>\n
  2. The Story of Deciphering the Ribosome – with Venki Ramakrishnan (YouTube, The Royal Institution) https:\/youtu.be\/RYVdDJ1cFrM<\/a><\/li>\n
  3. \u201cRibosome reader to Royal Society leader: a biologist’s road to the Nobel\u201d, Nature<\/em> 561, 32 (2018)<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    \u300c\u4e2d\u592e\u7814\u7a76\u9662\u8b1b\u5ea7\u300d\u65bc\u672c\uff082023\uff09\u5e74 8 \u6708\u9080\u8acb\u82f1\u570b\u528d\u6a4b\u5206\u5b50\u751f\u7269\u5b78\u5be6\u9a57\u5ba4\uff08The Medical Resear […]<\/p>\n","protected":false},"author":1,"featured_media":32273,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[991,983],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32221"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=32221"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32221\/revisions"}],"predecessor-version":[{"id":32290,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/32221\/revisions\/32290"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/32273"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=32221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=32221"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=32221"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}