{"id":31751,"date":"2023-06-29T00:14:42","date_gmt":"2023-06-28T16:14:42","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=31751"},"modified":"2023-06-29T01:16:28","modified_gmt":"2023-06-28T17:16:28","slug":"%e5%97%9c%e4%b8%ad%e6%80%a7%e7%90%83%e8%83%9e%e5%a4%96%e8%aa%98%e6%8d%95%e7%b6%b2%e5%8f%8a-ccl4l2-%e6%98%af%e5%bd%b1%e9%9f%bf%e6%b0%a3%e5%96%98%e9%a1%9e%e5%9b%ba%e9%86%87%e6%b2%bb%e7%99%82%e6%95%88","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/31751\/","title":{"rendered":"\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u53ca CCL4L2 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NETs\uff09\u88ab\u767c\u73fe\u8207\u6c23\u5598\u75c7\u72c0\u7684\u56b4\u91cd\u6027\u6709\u95dc\u806f\uff0c\u800c\u672c\u7814\u7a76\u76ee\u7684\u5373\u662f\u70ba\u77ad\u89e3\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u5728\u6c23\u5598\u4e2d\u626e\u6f14\u7684\u89d2\u8272\u3002<\/p>\n<p>\u5728\u672c\u9662\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u674e\u6c38\u51cc\u535a\u58eb\u8207\u5f35\u96c5\u8c9e\u535a\u58eb\u5718\u968a\u5408\u4f5c\u4e0b\uff0c\u904b\u7528\u7fa4\u96c6\u5206\u6790\u7b49\u751f\u7269\u8cc7\u8a0a\u6280\u8853\u4f86\u5206\u6790\u6c23\u5598\u75c5\u4eba\u8840\u6db2\u7684\u57fa\u56e0\u8f49\u9304\u9ad4\u6578\u64da\uff0c\u4e26\u7d50\u5408\u7d30\u80de\u53ca\u5c0f\u9f20\u6c23\u5598\u52d5\u7269\u6a21\u5f0f\u5be6\u9a57\uff0c\u4f86\u63a2\u8a0e\u57fa\u56e0\u3001\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u3001\u6c23\u5598\u7684\u95dc\u806f\u3002\u7814\u7a76\u767c\u73fe\u9020\u6210\u6c23\u5598\u63a7\u5236\u4e0d\u826f\u7684\u57fa\u56e0\u7fa4\u8207\u55dc\u4e2d\u6027\u7403\u7684\u751f\u7269\u8def\u5f91\u6709\u95dc\uff0c\u800c\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u7684\u751f\u6210\u91cf\uff0c\u53ef\u4ee5\u7528\u4f86\u9810\u6e2c\u6c23\u5598\u75c5\u4eba\u5c0d\u5438\u5165\u6027\u985e\u56fa\u9187\u6cbb\u7642\u662f\u5426\u53ef\u4ee5\u7de9\u89e3\u6c23\u5598\u75c7\u72c0\uff0c\u540c\u6642\u4e5f\u8b49\u5be6\u4e86\u53bb\u6c27\u6838\u91a3\u6838\u9178\u9176 I \uff08DNase I\uff09\uff0c\u900f\u904e\u963b\u7919\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u7684\u751f\u6210\uff0c\u6bd4\u5438\u5165\u6027\u985e\u56fa\u9187\u66f4\u80fd\u6709\u6548\u6291\u5236\u55dc\u4e2d\u6027\u7403\u6240\u5f15\u767c\u7684\u547c\u5438\u9053\u767c\u708e\u53cd\u61c9\u3002\u91dd\u5c0d\u55dc\u4e2d\u6027\u7403\u57fa\u56e0\u8f49\u9304\u9ad4\u7684\u5206\u6790\u4e5f\u767c\u73fe\uff0c\u5c0d\u5438\u5165\u6027\u985e\u56fa\u9187\u6cbb\u7642\u53cd\u61c9\u4e0d\u4f73\u7684\u60a3\u8005\u6709\u8f03\u9ad8\u7684 CCL4L2 \u57fa\u56e0\u8868\u73fe\uff0c\u4e14 CCL4L2 \u7684\u8868\u73fe\u91cf\u4e5f\u8207\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u7684\u751f\u6210\u91cf\u5448\u73fe\u986f\u8457\u7684\u6b63\u76f8\u95dc\u6027\u3002\u672c\u7814\u7a76\u7684\u6210\u679c\u986f\u793a\uff0c\u5c0d\u5438\u5165\u6027\u985e\u56fa\u9187\u85e5\u7269\u6cbb\u7642\u53cd\u61c9\u4e0d\u4f73\u7684\u6c23\u5598\u75c5\u4eba\uff0c\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u53ca CCL4L2 \u662f\u53ef\u767c\u5c55\u7684\u6f5b\u5728\u6cbb\u7642\u6a19\u7684\u3002<\/p>\n<p>\u672c\u7814\u7a76\u4e3b\u8981\u7531\u751f\u7269\u91ab\u5b78\u79d1\u5b78\u7814\u7a76\u6240\u674e\u6c38\u51cc\u535a\u58eb\u3001\u5f35\u96c5\u8c9e\u535a\u58eb\u5408\u4f5c\u5b8c\u6210\uff0c\u53c3\u8207\u7684\u4eba\u54e1\u6709\u8521\u975c\u6167\u535a\u58eb\u3001\u8cf4\u50b3\u7a4e\u535a\u58eb\u3002\u53f0\u5927\u91ab\u9662\u3001\u8f14\u5927\u91ab\u9662\u3001\u99ac\u5055\u91ab\u9662\u5354\u52a9\u81e8\u5e8a\u6536\u6848\uff0cUniversity of Amsterdam \u3001 Brigham and Women\u2019s Hospital \u53ca Harvard Medical School \u4ea6\u53c3\u8207\u57fa\u56e0\u5927\u6578\u64da\u8cc7\u6599\u5408\u4f5c\u3002\u6b64\u7814\u7a76\u611f\u8b1d\u4e2d\u7814\u9662\u3001\u570b\u79d1\u6703\u53ca\u570b\u885b\u9662\u7814\u7a76\u7d93\u8cbb\u7684\u652f\u6301\uff0c\u672c\u7814\u7a76\u6210\u679c\u767c\u8868\u5728\u570b\u969b\u671f\u520a\u300a\u79d1\u5b78\u8f49\u5316\u91ab\u5b78\u300b\uff08<em>Science Translational Medicine<\/em>\uff09\u3002<\/p>\n<p>\u8ad6\u6587\u9023\u7d50\uff1a <a href=\"https:\/www.science.org\/doi\/10.1126\/scitranslmed.adf3843\" rel=\"noopener\" target=\"_blank\">https:\/www.science.org\/doi\/10.1126\/scitranslmed.adf3843<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/3-1-1.jpg\" alt=\"\u55dc\u4e2d\u6027\u7403\u80de\u5916\u8a98\u6355\u7db2\u53ca CCL4L2 \u662f\u5f71\u97ff\u6c23\u5598\u985e\u56fa\u9187\u6cbb\u7642\u6548\u679c\u7684\u95dc\u9375\" width=\"836\" height=\"504\" class=\"aligncenter size-full wp-image-31752\" srcset=\"https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/3-1-1.jpg 836w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/3-1-1-300x181.jpg 300w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/3-1-1-768x463.jpg 768w, https:\/newsletter.sinica.edu.tw\/wp-content\/uploads\/2023\/06\/3-1-1-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6c23\u5598\u662f\u4e00\u7a2e\u5e38\u898b\u7684\u6162\u6027\u547c\u5438\u9053\u75be\u75c5\u3002\u5118\u7ba1\u5438\u5165\u6027\u985e\u56fa\u9187\u85e5\u7269\u5df2\u88ab\u5ee3\u6cdb\u7684\u4f5c\u70ba\u7b2c\u4e00\u7dda\u6c23\u5598\u6cbb\u7642\u7528\u85e5\uff0c\u4f46\u662f\u90e8\u5206\u75c5\u4eba\u5373\u4f7f\u5df2\u7d93\u6b63\u78ba [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":31753,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[988,984],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/31751"}],"collection":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/comments?post=31751"}],"version-history":[{"count":1,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/31751\/revisions"}],"predecessor-version":[{"id":31787,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/posts\/31751\/revisions\/31787"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media\/31753"}],"wp:attachment":[{"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/media?parent=31751"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/categories?post=31751"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/newsletter.sinica.edu.tw\/wp-json\/wp\/v2\/tags?post=31751"}],"curies":[{"name":"wp","href":"https:\/api.w.org\/{rel}","templated":true}]}}