{"id":15348,"date":"2018-11-08T08:30:19","date_gmt":"2018-11-08T00:30:19","guid":{"rendered":"https:\/newsletter.sinica.edu.tw\/?p=15348"},"modified":"2021-08-12T11:38:18","modified_gmt":"2021-08-12T03:38:18","slug":"%e7%b5%95%e8%99%95%e9%80%a2%e7%94%9f%e7%9a%84%e6%bc%94%e5%8c%96%e5%a5%a7%e7%a7%98","status":"publish","type":"post","link":"https:\/newsletter.sinica.edu.tw\/15348\/","title":{"rendered":"\u57fa\u56e0\u9ad4\u4e2d\u5fc3 \u767c\u73fe\u7d55\u8655\u9022\u751f\u7684\u6f14\u5316\u5967\u79d8"},"content":{"rendered":"

\u751f\u7269\u5931\u53bb\u5fc5\u8981\u57fa\u56e0\uff0c\u4e5f\u80fd\u6f14\u5316\u6c42\u751f\u3002<\/p>\n

\u9175\u6bcd\u83cc\u662f\u771f\u6838\u751f\u7269\uff0c\u5c31\u50cf\u4eba\u985e\u7d30\u80de\u4e00\u6a23\uff0c\u6240\u4ee5\u9664\u4e86\u7528\u4f86\u91c0\u9152\u8207\u70d8\u7119\u4e4b\u5916\uff0c\u4e5f\u662f\u5206\u5b50\u751f\u7269\u5b78\u7814\u7a76\u7684\u91cd\u8981\u6a21\u5f0f\u751f\u7269\u3002\u5b83\u7d04\u6709\u516d\u5343\u500b\u57fa\u56e0\uff0c\u5176\u4e2d\u4e00\u5343\u591a\u500b\u57fa\u56e0\u662f\u4e0d\u53ef\u6216\u7f3a\u7684\u300c\u5fc5\u8981\u57fa\u56e0\u300d(Essential gene)\u3002\u9019\u4e9b\u300c\u5fc5\u8981\u57fa\u56e0\u300d\u4e5f\u5b58\u5728\u65bc\u4eba\u985e\u9ad4\u5167\uff0c\u6240\u4ee5\u5b83\u5011\u4e0d\u50c5\u662f\u7fa4\u53e4\u8001\u7684\u57fa\u56e0\uff0c\u4e5f\u662f\u751f\u7269\u57fa\u56e0\u9ad4\u5167\u6700\u91cd\u8981\u4e14\u6700\u6838\u5fc3\u7684\u4e00\u7fa4\u57fa\u56e0\u3002\u5982\u679c\u9019\u4e9b\u5fc5\u8981\u57fa\u56e0\u4e00\u4f46\u88ab\u5254\u9664\uff0c\u7d30\u80de\u5fc5\u6b7b\u7121\u7591\u3002<\/p>\n

\u53ef\u662f\uff0c\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u5f35\u5178\u986f\u526f\u4e3b\u4efb\u7684\u7814\u7a76\u5718\u968a\u767c\u73fe\uff1a\u4ee3\u8a8c\u4e0d\u662f\u61a8\u4eba\u60f3\u7684\u90a3\u9ebc\u7c21\u55ae\u3002\u9019\u9805\u7814\u7a76\u5df2\u65bc2018\u5e7410\u6708\u767b\u4e0a\u570b\u969b\u5b78\u8853\u671f\u520a\u300a\u81ea\u7136\u751f\u614b\u6f14\u5316\u300b(Nature Ecology and Evolution)\uff0c\u672c\u9662\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u65bc11\u67088\u65e5\u8209\u8fa6\u8a18\u8005\u6703\u8aaa\u660e\u3002<\/p>\n

\"\"<\/p>\n

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\u5728\u8ca0\u8cac\u526a\u63a5RNA\u7684\u526a\u63a5\u9ad4 (Spliceosome)\u4e2d\uff0c\u300cPRP28\u300d\u662f\u4e00\u500b\u4e0d\u53ef\u6216\u7f3a\u7684\u96f6\u7d44\u4ef6\u3002\u7576\u5931\u53bb\u4e86\u300cPRP28\u300d\uff0cRNA\u526a\u63a5\u7121\u6cd5\u9032\u884c\uff0c\u7d30\u80de\u5c31\u6703\u6b7b\u6389\u3002\u5f35\u5178\u986f\u5718\u968a\u767c\u73fe\uff0c\u5c07\u300cPRP28\u300d\u642d\u914d\u7684\u96f6\u7d44\u4ef6\u9032\u884c\u4e92\u88dc\u6027\u7684\u6539\u8b8a\uff0c\u7d30\u80de\u5c31\u53ef\u4ee5\u4e0d\u9700\u8981\u300cPRP28\u300d\u3002\u4f46\u9019\u7a2e\u7f3a\u5c11\u300cPRP28\u300d\u7684\u9175\u6bcd\u83cc\u56e0\u70baRNA\u526a\u63a5\u6548\u7387\u4f4e\uff0c\u5c0e\u81f4\u751f\u9577\u5f97\u6bd4\u8f03\u5dee\u3002\u672c\u8ad6\u6587\u7b2c\u4e00\u4f5c\u8005\u5f35\u5c1a\u9e9f\u535a\u58eb\u9032\u4e00\u6b65\u63a2\u8a62\uff0c\u9019\u7a2e\u751f\u9577\u6bd4\u8f03\u5dee\u7684\u9175\u6bcd\u83cc\u80fd\u5426\u518d\u56de\u5230\u539f\u672c\u5145\u6eff\u6d3b\u529b\u7684\u751f\u9577\u72c0\u614b\uff1f\u4e5f\u5c31\u662f\u8aaa\uff0c\u7576\u6c38\u9060\u5931\u53bb\u3127\u500b\u5fc5\u8981\u57fa\u56e0\u4e4b\u5f8c\uff0c\u751f\u7269\u7cfb\u7d71\u8981\u5982\u4f55\u61c9\u8b8a\u4ee5\u88dc\u511f\u9019\u500b\u640d\u5931\uff1f<\/p>\n

\u5229\u7528\u9175\u6bcd\u83cc\uff0c\u4ed6\u5011\u505a\u4e86\u4e00\u500b\u7e2e\u6642\u6f14\u5316\u5be6\u5883\u79c0\uff1a\u8b93\u7f3a\u5c11\u4e86\u5fc5\u8981\u751f\u9577\u57fa\u56e0\u7684\u9175\u6bcd\u83cc\u5728\u5be6\u9a57\u5ba4\u6f14\u5316\uff0c\u7522\u751f\u9069\u61c9\u6027\u7a81\u8b8a\uff0c\u4e26\u4e00\u8def\u89c0\u5bdf\u751f\u9577\u901f\u5ea6\u662f\u5426\u52a0\u5feb\uff0c\u6700\u5f8c\u9054\u5230\u6700\u4f73\u72c0\u614b\u3002\u5931\u53bb\u300cPRP28\u300d\u7684\u9175\u6bcd\u83cc\u7d93\u904e\u4e86300\u500b\u4e16\u4ee3\u6f14\u5316\u4e4b\u5f8c\uff0c\u51fa\u4e4e\u610f\u6599\u5730\u56de\u5230\u4e86\u5065\u5eb7\u7684\u72c0\u614b\uff0c\u4e0a\u6f14\u4e86\u7d55\u8655\u9022\u751f\u7684\u5927\u9a5a\u5947\u3002<\/p>\n

\u7814\u7a76\u5718\u968a\u6df1\u5165\u8abf\u67e5\u5f8c\uff0c\u767c\u73fe\u6f14\u5316\u5f8c\u7684\u9175\u6bcd\u83cc\u53ef\u85c9\u7531\u964d\u4f4e\u4e0a\u6e38\u8f49\u9304(Transcription)\u7684\u6548\u7387\uff0c\u8b93\u8f49\u9304\u8207RNA\u526a\u63a5(Splicing)\u518d\u5ea6\u540c\u6b65\u5316\uff0c\u50cf\u662f\u4e00\u7a2e\u8ca0\u8ca0\u5f97\u6b63\u7684\u6982\u5ff5\uff0c\u85c9\u6b64\u91cd\u65b0\u512a\u5316\u7d30\u80de\u6574\u9ad4\u57fa\u56e0\u7684\u8868\u73fe\u3002\u9019\u500b\u5be6\u9a57\u7d50\u679c\u986f\u793a\uff0c\u751f\u7269\u7cfb\u7d71\u4e2d\u6709\u8a31\u591a\u932f\u7d9c\u8907\u96dc\u7684\u57fa\u56e0\u8868\u73fe\u8def\u5f91\uff0c\u4e0d\u540c\u6b65\u9a5f\u53ef\u4ee5\u4e92\u76f8\u5f71\u97ff\uff08\u4f8b\u5982\uff1aRNA\u8f49\u9304\u8207RNA\u526a\u63a5\uff09\uff0c\u8b93\u6211\u5011\u66f4\u4e86\u89e3\u7d30\u80de\u904b\u8f49\u7684\u908f\u8f2f\u8207\u751f\u7269\u7cfb\u7d71\u7684\u6f14\u5316\u3002\u9019\u500b\u89c0\u5ff5\u53ef\u4ee5\u88ab\u904b\u7528\u5230\u751f\u7269\u7cfb\u7d71\u7684\u512a\u5316\uff0c\u63d0\u4f9b\u672a\u4f86\u8a2d\u8a08\u8abf\u63a7\u751f\u7269\u7cfb\u7d71\u7684\u65b0\u8def\u5f91\u3002\u6bd4\u5982\u8aaa\uff0c\u5728\u958b\u767c\u6cbb\u7642\u75be\u75c5\u7684\u85e5\u7269\u6642\uff0c\u53ef\u91dd\u5c0d\u6a19\u7684\u7269\u7684\u4e0a\u4e0b\u6e38\u9032\u884c\u8abf\u6574\u4ee5\u9054\u5230\u7cfb\u7d71\u7684\u6574\u9ad4\u5e73\u8861\u3002<\/p>\n

\u672c\u8ad6\u6587\u5171\u540c\u4f5c\u8005\u9084\u5305\u62ec\uff1a\u81fa\u7063\u5927\u5b78\u57fa\u56e0\u9ad4\u8207\u7cfb\u7d71\u751f\u7269\u5b78\u7a0b\u535a\u58eb\u73ed\u5b78\u751f\u738b\u5ba3\u51f1\uff0c\u4ee5\u53ca\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\u535a\u58eb\u5f8c\u7814\u7a76\u54e1\u8463\u7490\u3002<\/p>\n

\uff08\u57fa\u56e0\u9ad4\u7814\u7a76\u4e2d\u5fc3\uff09<\/p>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

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