{"id":7230,"date":"2020-06-04T00:00:23","date_gmt":"2020-06-03T16:00:23","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=7230"},"modified":"2024-03-13T09:18:15","modified_gmt":"2024-03-13T01:18:15","slug":"a-promising-trisaccharide-identified-for-damaged-cartilage","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/7230\/","title":{"rendered":"A Promising Trisaccharide Identified for Damaged Cartilage"},"content":{"rendered":"
“Bad Knees” is not an unfamiliar topic among older folks. Most of the complaints are pains and swellings, accompanying clicking and locking at the joints. Some people believe it\u2019s a sign of ageing when one starts feeling funny at the knees. And it may just be true! Although the disease has been long recognized, the exact cause remains unknown. A team led by Professor Shang-Cheng Hung, Professor Chi-Huey Wong and Dr. Rachel Cheng dug into this problem around seven years ago.<\/p>\n
Now, a report of how a trisaccharide structure was proved to be the ultimate substrate to en-do-O-sulfatase-1(Sulf-1) has been published. They have not only unraveled the key to a known mystery but also proposed a structure as a potential inhibitor to solve the problem. The detail was published in Journal of the American Chemical Society (JACS)<\/em>.<\/p>\n