{"id":12827,"date":"2023-12-14T00:03:12","date_gmt":"2023-12-13T16:03:12","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=12827"},"modified":"2024-03-13T09:19:02","modified_gmt":"2024-03-13T01:19:02","slug":"a-breakthrough-for-treating-genetic-skeletal-dysplasia","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/12827\/","title":{"rendered":"A breakthrough for treating genetic skeletal dysplasia"},"content":{"rendered":"<p>Overactive FGFR3 contributes to various cancers and a range of genetic short-limbed bone disorders, including achondroplasia, the most common human dwarfism. Targeting FGFR3 activity presents a promising therapeutic approach for treating these diseases. Dr. Yi-Ching Lee and her team at the Institute of Cellular and Organismic Biology, Academia Sinica have developed a screening system to identify bioactive compounds from plant extracts. They discovered a compound accelerating FGFR3 degradation, demonstrating promising potential as a therapeutic candidate for treating FGFR3-associated cancers and bone disorders. This study was published on November 22, 2023, in <em>JCI Insight<\/em>, and is pending patent protection in several countries. The research team includes graduate student Yun-Wen Lin, research assistant Wei-Ting Chen, Dr. Cheng-Fu Kao, and Dr. Yi-Ching Lee from the Institute of Cellular and Organismic Biology, collaborating with Dr. Hsiao-Jung Kao, Dr. Jer-Yuarn Wu, and Dr. Yuan-Tsong Chen from the Institute of Biomedical Sciences, Academia Sinica. <\/p>\n<p>Article link:<a href=\"https:\/\/insight.jci.org\/articles\/view\/171257\" rel=\"noopener\" target=\"_blank\"> https:\/\/insight.jci.org\/articles\/view\/171257<\/a><br \/>\nRelated link: <a href=\"https:\/\/icob.sinica.edu.tw\/Eng\/Information\/research_more?id=9030243e31314b65949bd4b69769e77d\" rel=\"noopener\" target=\"_blank\">https:\/\/icob.sinica.edu.tw\/Eng\/Information\/research_more?id=9030243e31314b65949bd4b69769e77d<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/12\/3-1-1024x433.jpg\" alt=\"A breakthrough for treating genetic skeletal dysplasia\" width=\"1024\" height=\"433\" class=\"aligncenter size-large wp-image-12828\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/12\/3-1-1024x433.jpg 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/12\/3-1-300x127.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/12\/3-1-768x324.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/12\/3-1-1536x649.jpg 1536w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/12\/3-1-1080x456.jpg 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/12\/3-1.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Overactive FGFR3 contributes to various cancers and a range of genetic short-limbed bone disorders, including achondroplasia, the most common human dwarfism. Targeting FGFR3 activity presents a promising therapeutic approach for treating these diseases. Dr. Yi-Ching Lee and her team at the Institute of Cellular and Organismic Biology, Academia Sinica have developed a screening system to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":12829,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/12827"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=12827"}],"version-history":[{"count":1,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/12827\/revisions"}],"predecessor-version":[{"id":12830,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/12827\/revisions\/12830"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/12829"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=12827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=12827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=12827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}