{"id":12007,"date":"2023-06-15T00:03:38","date_gmt":"2023-06-14T16:03:38","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=12007"},"modified":"2024-03-13T09:19:02","modified_gmt":"2024-03-13T01:19:02","slug":"inhibition-of-sars-cov-2-mediated-thromboinflammation-by-clec2-fc","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/12007\/","title":{"rendered":"Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc"},"content":{"rendered":"<p>Immunothrombosis is the major cause of mortality and morbidity in acute COVID-19 and long COVID patients. However, the underlying mechanism is unclear. Dr. Hsieh\u2019s research team unravel the mystery by showing that CLEC2 is the pattern recognition receptor for SARS CoV-2 spike protein, contributes for SARS CoV-2-induced NETosis and thromboinflammation, and injection of recombinant CLEC2.Fc inhibits immunothrombosis and alleviate visceral organ injury, suggesting targeting CLEC2 is promising to treat SARS-CoV-2-induced thrombosis in the future.<\/p>\n<p>Article link:<a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.202216351\" rel=\"noopener\" target=\"_blank\"> https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.202216351<\/a><br \/>\nRelated link: <a href=\"https:\/\/www.genomics.sinica.edu.tw\/index.php\/en\/news\/latest-news?as_qdr=all&#038;cr=countrytw&#038;ct=clnk&#038;d=..\/&#038;hl=fr&#038;num=100&#038;tbs=ctr:countrytw&#038;fbclid=IwAR0EVtel2ieq0WU_M3crfXxo-T0N866ddZnY892B2jMMXXLxzONfbpQ1Rnw\" rel=\"noopener\" target=\"_blank\">https:\/\/www.genomics.sinica.edu.tw\/index.php\/en\/news\/latest-news?as_qdr=all&#038;cr=countrytw&#038;ct=clnk&#038;d=..\/&#038;hl=fr&#038;num=100&#038;tbs=ctr:countrytw&#038;fbclid=IwAR0EVtel2ieq0WU_M3crfXxo-T0N866ddZnY892B2jMMXXLxzONfbpQ1Rnw<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/06\/3-1.jpg\" alt=\"Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc\" width=\"836\" height=\"504\" class=\"aligncenter size-full wp-image-12008\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/06\/3-1.jpg 836w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/06\/3-1-300x181.jpg 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/06\/3-1-768x463.jpg 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/06\/3-1-440x264.jpg 440w\" sizes=\"(max-width: 836px) 100vw, 836px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immunothrombosis is the major cause of mortality and morbidity in acute COVID-19 and long COVID patients. However, the underlying mechanism is unclear. Dr. Hsieh\u2019s research team unravel the mystery by showing that CLEC2 is the pattern recognition receptor for SARS CoV-2 spike protein, contributes for SARS CoV-2-induced NETosis and thromboinflammation, and injection of recombinant CLEC2.Fc [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":12009,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/12007"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=12007"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/12007\/revisions"}],"predecessor-version":[{"id":13144,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/12007\/revisions\/13144"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/12009"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=12007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=12007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=12007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}