{"id":11730,"date":"2023-05-04T00:04:41","date_gmt":"2023-05-03T16:04:41","guid":{"rendered":"https:\/\/newsletter.sinica.edu.tw/en\/?p=11730"},"modified":"2024-03-13T09:19:02","modified_gmt":"2024-03-13T01:19:02","slug":"rna-participates-in-dna-damage-repair","status":"publish","type":"post","link":"https:\/\/newsletter.sinica.edu.tw/en\/11730\/","title":{"rendered":"RNA participates in DNA damage repair"},"content":{"rendered":"<p>The high frequency of DNA damage necessitates effective repair mechanisms. Evidence is mounting that RNA plays an important role in DNA repair. Distinguished Research Fellow Woan-Yuh Tarn in the Institute of Biomedical Sciences, Academia Sinica found that the long non-coding RNA <em>HOTAIRM1<\/em> brings mRNA surveillance factors to the DNA damage sites, which degrade the transcripts induced by double-strand breaks. Such RNA clearance facilitates the turnover of DNA repair and hence increases the efficiency of DNA repair. Meanwhile, Tarn\u2019s group found that co-phase separation between non-coding RNA and RNA binding protein Y14 may contribute to the repair of DNA damage. These studies have been published in <em>Nucleic Acids Research<\/em> and <em>RNA<\/em>, respectively. <\/p>\n<p>For further information:<br \/>\n<a href=\"https:\/\/www.ibms.sinica.edu.tw\/en\/news\/2023-472.html\" rel=\"noopener\" target=\"_blank\">https:\/\/www.ibms.sinica.edu.tw\/en\/news\/2023-472.html<\/a><\/p>\n<p>Article Link:<br \/>\n<em>Nucleic Acids Research<\/em>: <a href=\"https:\/\/doi.org\/10.1093\/nar\/gkad143\" rel=\"noopener\" target=\"_blank\">https:\/\/doi.org\/10.1093\/nar\/gkad143<\/a><br \/>\n<em>RNA<\/em>: <a href=\"https:\/\/doi.org\/10.1261\/rna.079514.122\" rel=\"noopener\" target=\"_blank\">https:\/\/doi.org\/10.1261\/rna.079514.122<\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/05\/3-2-1024x617.png\" alt=\"RNA participates in DNA damage repair\" width=\"1024\" height=\"617\" class=\"aligncenter size-large wp-image-11732\" srcset=\"https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/05\/3-2-1024x617.png 1024w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/05\/3-2-300x181.png 300w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/05\/3-2-768x463.png 768w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/05\/3-2-1080x651.png 1080w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/05\/3-2-440x264.png 440w, https:\/\/newsletter.sinica.edu.tw/en\/wp-content\/uploads\/2023\/05\/3-2.png 1115w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The high frequency of DNA damage necessitates effective repair mechanisms. Evidence is mounting that RNA plays an important role in DNA repair. Distinguished Research Fellow Woan-Yuh Tarn in the Institute of Biomedical Sciences, Academia Sinica found that the long non-coding RNA HOTAIRM1 brings mRNA surveillance factors to the DNA damage sites, which degrade the transcripts [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":11733,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[533],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11730"}],"collection":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/comments?post=11730"}],"version-history":[{"count":2,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11730\/revisions"}],"predecessor-version":[{"id":13147,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/posts\/11730\/revisions\/13147"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media\/11733"}],"wp:attachment":[{"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/media?parent=11730"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/categories?post=11730"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/newsletter.sinica.edu.tw/en\/wp-json\/wp\/v2\/tags?post=11730"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}